Search Results - "HINTON, David R"

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration by Ishikawa, Keijiro, Kannan, Ram, Hinton, David R.

“…Subretinal fibrosis is a result of a wound healing response that follows choroidal neovascularization in neovascular age-related macular degeneration (nAMD)…”
Get full text

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction by Sreekumar, Parameswaran G, Ishikawa, Keijiro, Spee, Chris, Mehta, Hemal H, Wan, Junxiang, Yen, Kelvin, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death,…”
Get full text

Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina by Shi, Haoshen, Koronyo, Yosef, Rentsendorj, Altan, Regis, Giovanna C., Sheyn, Julia, Fuchs, Dieu-Trang, Kramerov, Andrei A., Ljubimov, Alexander V., Dumitrascu, Oana M., Rodriguez, Anthony R., Barron, Ernesto, Hinton, David R., Black, Keith L., Miller, Carol A., Mirzaei, Nazanin, Koronyo-Hamaoui, Maya

“…Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood–brain barrier breakdown…”
Get full text

Stem cell based therapies for age-related macular degeneration: The promises and the challenges by Nazari, Hossein, Zhang, Li, Zhu, Danhong, Chader, Gerald J., Falabella, Paulo, Stefanini, Francisco, Rowland, Teisha, Clegg, Dennis O., Kashani, Amir H., Hinton, David R., Humayun, Mark S.

“…Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. AMD is classified as either neovascular…”
Get full text

Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer by Diniz, Bruno, Thomas, Padmaja, Thomas, Biju, Ribeiro, Ramiro, Hu, Yuntao, Brant, Rodrigo, Ahuja, Ashish, Zhu, Danhong, Liu, Laura, Koss, Michael, Maia, Mauricio, Chader, Gerald, Hinton, David R, Humayun, Mark S

“…To evaluate cell survival and tumorigenicity of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation in immunocompromised…”
Get full text

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione by Matsunaga, Douglas, Sreekumar, Parameswaran G, Ishikawa, Keijiro, Terasaki, Hiroto, Barron, Ernesto, Cohen, Pinchas, Kannan, Ram, Hinton, David R

“…Humanin (HN) is a small mitochondrial-encoded peptide with neuroprotective properties. We have recently shown protection of retinal pigmented epithelium (RPE)…”
Get full text

The Emerging Role of Senescence in Ocular Disease by Sreekumar, Parameswaran G., Kannan, Ram, Hinton, David R.

“…Cellular senescence is a state of irreversible cell cycle arrest in response to an array of cellular stresses. An important role for senescence has been shown…”
Get full text

Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration by Kannan, Ram, Sreekumar, Parameswaran G., Hinton, David R.

“…αA- and αB crystallins are principal members of the small heat shock protein family and elicit both a cell protective function and a chaperone function…”
Get full text

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity by Fowler, Benjamin J., Gelfand, Bradley D., Kim, Younghee, Kerur, Nagaraj, Tarallo, Valeria, Hirano, Yoshio, Amarnath, Shoba, Fowler, Daniel H., Radwan, Marta, Young, Mark T., Pittman, Keir, Kubes, Paul, Agarwal, Hitesh K., Parang, Keykavous, Hinton, David R., Bastos-Carvalho, Ana, Li, Shengjian, Yasuma, Tetsuhiro, Mizutani, Takeshi, Yasuma, Reo, Wright, Charles, Ambati, Jayakrishna

“…Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that…”
Get full text

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88 by Tarallo, Valeria, Hirano, Yoshio, Gelfand, Bradley D., Dridi, Sami, Kerur, Nagaraj, Kim, Younghee, Cho, Won Gil, Kaneko, Hiroki, Fowler, Benjamin J., Bogdanovich, Sasha, Albuquerque, Romulo J.C., Hauswirth, William W., Chiodo, Vince A., Kugel, Jennifer F., Goodrich, James A., Ponicsan, Steven L., Chaudhuri, Gautam, Murphy, Michael P., Dunaief, Joshua L., Ambati, Balamurali K., Ogura, Yuichiro, Yoo, Jae Wook, Lee, Dong-ki, Provost, Patrick, Hinton, David R., Núñez, Gabriel, Baffi, Judit Z., Kleinman, Mark E., Ambati, Jayakrishna

“…Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form…”
Get full text

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells by Kannan, Ram, Hinton, David R., Sreekumar, Parameswaran G., Minasyan, Leonid

“…Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the…”
Get full text

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells by Hinton, David R, Sonoda, Shozo, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Kannan, Ram

“…We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly…”
Get full text

Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy by Ishikawa, Keijiro, He, Shikun, Terasaki, Hiroto, Nazari, Hossein, Zhang, Huiming, Spee, Christine, Kannan, Ram, Hinton, David R

“…Proliferative vitreoretinopathy (PVR) is a serious complication of retinal detachment and ocular trauma and its recurrence may lead to irreversible vision…”
Get full text

Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease by Koronyo, Yosef, Biggs, David, Barron, Ernesto, Boyer, David S, Pearlman, Joel A, Au, William J, Kile, Shawn J, Blanco, Austin, Fuchs, Dieu-Trang, Ashfaq, Adeel, Frautschy, Sally, Cole, Gregory M, Miller, Carol A, Hinton, David R, Verdooner, Steven R, Black, Keith L, Koronyo-Hamaoui, Maya

“…Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification of at-risk populations for…”
Get full text

SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization by Zhang, Huiming, He, Shikun, Spee, Christine, Ishikawa, Keijiro, Hinton, David R.

“…SIRT1, a NAD+ -dependent histone deacetylase, has been shown to act as a key regulator of angiogenesis. The purpose of this study was to determine the effects…”
Get full text

Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes by Huang, Alex S, Saraswathy, Sindhu, Dastiridou, Anna, Begian, Alan, Mohindroo, Chirayu, Tan, James C H, Francis, Brian A, Hinton, David R, Weinreb, Robert N

“…To assess the ability of trabecular micro-bypass stents to improve aqueous humor outflow (AHO) in regions initially devoid of AHO as assessed by aqueous…”
Get full text

αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells by Sreekumar, Parameswaran G, Kannan, Ram, Kitamura, Mizuki, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Hinton, David R

“…αB crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and has been identified as a biomarker in age-related macular…”
Get full text

Protection of retina by αB crystallin in sodium iodate induced retinal degeneration by Zhou, Peng, Kannan, Ram, Spee, Christine, Sreekumar, Parameswaran G, Dou, Guorui, Hinton, David R

“…Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of…”
Get full text

WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing by Amin, Elianna M., Oltean, Sebastian, Hua, Jing, Gammons, Melissa V.R., Hamdollah-Zadeh, Maryam, Welsh, Gavin I., Cheung, Man-Kim, Ni, Lan, Kase, Satoru, Rennel, Emma S., Symonds, Kirsty E., Nowak, Dawid G., Royer-Pokora, Brigitte, Saleem, Moin A., Hagiwara, Masatoshi, Schumacher, Valérie A., Harper, Steven J., Hinton, David R., Bates, David O., Ladomery, Michael R.

“…Angiogenesis is regulated by the balance of proangiogenic VEGF 165 and antiangiogenic VEGF 165b splice isoforms. Mutations in WT1, the Wilms' tumor suppressor…”
Get full text

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs by Koss, Michael J., Falabella, Paulo, Stefanini, Francisco R., Pfister, Marcel, Thomas, Biju B., Kashani, Amir H., Brant, Rodrigo, Zhu, Danhong, Clegg, Dennis O., Hinton, David R., Humayun, Mark S.

“…Purpose A subretinal implant termed CPCB-RPE1 is currently being developed to surgically replace dystrophic RPE in patients with dry age-related macular…”
Get full text