Search Results - "HINSBERGH, Victor W. M. Van"

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity by Bakker, Wineke, Eringa, Etto C, Sipkema, Pieter, van Hinsbergh, Victor W. M

“…Endothelial dysfunction comprises a number of functional alterations in the vascular endothelium that are associated with diabetes and cardiovascular disease,…”
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Endothelium—role in regulation of coagulation and inflammation by van Hinsbergh, Victor W. M.

“…By its strategic position at the interface between blood and tissues, endothelial cells control blood fluidity and continued tissue perfusion while…”
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Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells by van der Heijden, Melanie, van Nieuw Amerongen, Geerten P, van Bezu, Jan, Paul, Marinus A, Groeneveld, A B Johan, van Hinsbergh, Victor W M

“…Angiopoietin-2 (Ang-2) is associated with lung injury in ALI/ARDS. As endothelial activation by thrombin plays a role in the permeability of acute lung injury…”
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Thin-Walled Microvessels in Human Coronary Atherosclerotic Plaques Show Incomplete Endothelial Junctions : Relevance of Compromised Structural Integrity for Intraplaque Microvascular Leakage by SLUIMER, Judith C, KOLODGIE, Frank D, DAEMEN, Mat J. A. P, BIJNENS, Ann P. J. J, MAXFIELD, Kimberly, PACHECO, Erica, KUTYS, Bob, DUIMEL, Hans, FREDERIK, Peter M, VAN HINSBERGH, Victor W. M, VIRMANI, Renu

“…This study sought to examine the ultrastructure of microvessels in normal and atherosclerotic coronary arteries and its association with plaque phenotype…”
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Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity by Tasev, Dimitar, van Wijhe, Michiel H, Weijers, Ester M, van Hinsbergh, Victor W M, Koolwijk, Pieter

“…Efficient implementation of peripheral blood-derived endothelial-colony cells (PB-ECFCs) as a therapeutical tool requires isolation and generation of a…”
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A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability by Amado-Azevedo, Joana, de Menezes, Renee X, van Nieuw Amerongen, Geerten P, van Hinsbergh, Victor W M, Hordijk, Peter L

“…Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If…”
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CD34 expression modulates tube-forming capacity and barrier properties of peripheral blood-derived endothelial colony-forming cells (ECFCs) by Tasev, Dimitar, Konijnenberg, Lara S. F., Amado-Azevedo, Joana, van Wijhe, Michiel H., Koolwijk, Pieter, van Hinsbergh, Victor W. M.

“…Endothelial colony-forming cells (ECFC) are grown from circulating CD34 + progenitors present in adult peripheral blood, but during in vitro expansion part of…”
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Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum by Greijer, Astrid E., Delis-van Diemen, Pien M., Fijneman, Remond J. A., Giles, Rachel H., Voest, Emile E., van Hinsbergh, Victor W. M., Meijer, Gerrit A.

“…Expression of the transcription factor hypoxia-inducible factor 1 (HIF-1), which plays a key role in cellular adaptation to hypoxia, was investigated in normal…”
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Fructose-mediated non-enzymatic glycation: sweet coupling or bad modification by Schalkwijk, Casper G., Stehouwer, Coen D. A., van Hinsbergh, Victor W. M.

“…The Maillard reaction is a process in which reducing sugars react spontaneously with amino groups in proteins to advanced glycation endproducts (AGEs)…”
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Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality by van der Heijden, Melanie, Pickkers, Peter, van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W. M., Bouw, Martijn P. W. J. M., van der Hoeven, Johannes G., Groeneveld, A. B. Johan

“…Purpose To investigate whether angiopoietin-2, von Willebrand factor (VWF) and angiopoietin-1 relate to surrogate indicators of vascular permeability,…”
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Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation by Engelse, Marten A., Laurens, Nancy, Verloop, Robert E., Koolwijk, Pieter, van Hinsbergh, Victor W. M.

“…The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in…”
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Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix by Collen, Annemie, Hanemaaijer, Roeland, Lupu, Florea, Quax, Paul H.A., van Lent, Natascha, Grimbergen, Jos, Peters, Erna, Koolwijk, Pieter, van Hinsbergh, Victor W.M.

“…Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly…”
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Therapeutic Potential of Human-Derived Endothelial Colony-Forming Cells in Animal Models by Tasev, Dimitar, Koolwijk, Pieter, van Hinsbergh, Victor W M

“…Tissue regeneration requires proper vascularization. In vivo studies identified that the endothelial colony-forming cells (ECFCs), a subtype of endothelial…”
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Using cultured endothelial cells to study endothelial barrier dysfunction: Challenges and opportunities by Aman, Jurjan, Weijers, Ester M, van Nieuw Amerongen, Geerten P, Malik, Asrar B, van Hinsbergh, Victor W M

“…Despite considerable progress in the understanding of endothelial barrier regulation and the identification of approaches that have the potential to improve…”
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Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib by AMAN, Jurjan, BEZU, Jan Van, DAMANAFSHAN, Amin, HUVENEERS, Stephan, ERINGA, Etto C, VOGEL, Steven M, JOHAN GROENEVELD, A. B, VONK NOORDEGRAAF, Anton, HINSBERGH, Victor W. M. Van, NIEUW AMERONGEN, Geerten P. Van

“…Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific…”
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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces by Krishnan, Ramaswamy, Klumpers, Darinka D, Park, Chan Y, Rajendran, Kavitha, Trepat, Xavier, van Bezu, Jan, van Hinsbergh, Victor W M, Carman, Christopher V, Brain, Joseph D, Fredberg, Jeffrey J, Butler, James P, van Nieuw Amerongen, Geerten P

“…A hallmark of many, sometimes life-threatening, inflammatory diseases and disorders is vascular leakage. The extent and severity of vascular leakage is broadly…”
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Hypoxic signaling during tissue repair and regenerative medicine by Nauta, Tessa D, van Hinsbergh, Victor W M, Koolwijk, Pieter

“…In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or…”
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Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib by Vroling, Laura, van der Veldt, Astrid A. M., de Haas, Richard R., Haanen, John B. A. G., Schuurhuis, Gerrit Jan, Kuik, Dirk J., van Cruijsen, Hester, Verheul, Henk M. W., van den Eertwegh, Alfons J. M., Hoekman, Klaas, Boven, Epie, van Hinsbergh, Victor W. M., Broxterman, Henk J.

“…Mature circulating endothelial cell (CEC) as well as endothelial progenitor populations may reflect the activity of anti-angiogenic agents on tumor…”
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Driving Rho GTPase activity in endothelial cells regulates barrier integrity by Beckers, Cora M L, van Hinsbergh, Victor W M, van Nieuw Amerongen, Geerten P

“…In the past decade understanding of the role of the Rho GTPases RhoA, Rac1 and Cdc42 has been developed from regulatory proteins that regulate specific actin…”
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Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation by Amado-Azevedo, Joana, van Stalborch, Anne-Marieke D., Valent, Erik T., Nawaz, Kalim, van Bezu, Jan, Eringa, Etto C., Hoevenaars, Femke P. M., De Cuyper, Iris M., Hordijk, Peter L., van Hinsbergh, Victor W. M., van Nieuw Amerongen, Geerten P., Aman, Jurjan, Margadant, Coert

“…Endothelial barrier disruption and vascular leak importantly contribute to organ dysfunction and mortality during inflammatory conditions like sepsis and acute…”
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