Search Results - "HINNEY, A"

Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis by Wojciechowski, P., Lipowska, A., Rys, P., Ewens, K. G., Franks, S., Tan, S., Lerchbaum, E., Vcelak, J., Attaoua, R., Straczkowski, M., Azziz, R., Barber, T. M., Hinney, A., Obermayer-Pietsch, B., Lukasova, P., Bendlova, B., Grigorescu, F., Kowalska, I., Goodarzi, M. O., Strauss, J. F., McCarthy, M. I., Malecki, M. T.

“…Aims/hypothesis FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small…”
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Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder by Jarick, I, Volckmar, A-L, Pütter, C, Pechlivanis, S, Nguyen, T T, Dauvermann, M R, Beck, S, Albayrak, Ö, Scherag, S, Gilsbach, S, Cichon, S, Hoffmann, P, Degenhardt, F, Nöthen, M M, Schreiber, S, Wichmann, H-E, Jöckel, K-H, Heinrich, J, Tiesler, C M T, Faraone, S V, Walitza, S, Sinzig, J, Freitag, C, Meyer, J, Herpertz-Dahlmann, B, Lehmkuhl, G, Renner, T J, Warnke, A, Romanos, M, Lesch, K-P, Reif, A, Schimmelmann, B G, Hebebrand, J, Scherag, A, Hinney, A

“…Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by…”
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Gain‐of‐function variants in the melanocortin 4 receptor gene confer susceptibility to binge eating disorder in subjects with obesity: a systematic review and meta‐analysis by Qasim, A., Mayhew, A. J., Ehtesham, S., Alyass, A., Volckmar, A.‐L., Herpertz, S., Hinney, A., Hebebrand, J., Meyre, D.

“…Summary The association between coding variants in the melanocortin 4 receptor gene (MC4R) and binge eating disorder (BED) in patients with obesity is…”
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V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals by Young, E.H, Wareham, N.J, Farooqi, S, Hinney, A, Hebebrand, J, Scherag, A, O'Rahilly, S, Barroso, I, Sandhu, M.S

“…Background: Previous studies have suggested that a variant in the melanocortin-4 receptor (MC4R) gene is important in protecting against common obesity. Larger…”
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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index by Hinney, A, Kesselmeier, M, Jall, S, Volckmar, A-L, Föcker, M, Antel, J, Heid, I M, Winkler, T W, Guo, Y, Bergen, A W, Kaye, W, Berrettini, W, Hakonarson, H, Herpertz-Dahlmann, B, de Zwaan, M, Herzog, W, Ehrlich, S, Zipfel, S, Egberts, K M, Adan, R, Brandys, M, van Elburg, A, Boraska Perica, V, Franklin, C S, Tschöp, M H, Zeggini, E, Bulik, C M, Collier, D, Scherag, A, Müller, T D, Hebebrand, J

“…The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid…”
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Association between the insulin-induced gene 2 ( ) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? by Le Hellard, S, Theisen, F M, Haberhausen, M, Raeder, M B, Fernø, J, Gebhardt, S, Hinney, A, Remschmidt, H, Krieg, J C, Mehler-Wex, C, Nöthen, M M, Hebebrand, J, Steen, V M

“…Atypical antipsychotics are nowadays the most widely used drugs to treat schizophrenia and other psychosis. Unfortunately, some of them can cause major…”
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Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention by Reinehr, T, Hinney, A, Toschke, A M, Hebebrand, J

“…Objective:Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning…”
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A genome-wide scan for attention-deficit hyperactivity disorder in 155 German sib-pairs by Hebebrand, J, Dempfle, A, Saar, K, Thiele, H, Herpertz-Dahlmann, B, Linder, M, Kiefl, H, Remschmidt, H, Hemminger, U, Warnke, A, Knölker, U, Heiser, P, Friedel, S, Hinney, A, Schäfer, H, Nürnberg, P, Konrad, K

“…Three groups have previously performed genome scans in attention-deficit/hyperactivity disorder (ADHD); linkage to chromosome 5p13 was detected in all of the…”
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Genetic and epigenetic mechanisms in obesity by Hinney, A, Herrfurth, N, Schonnop, L, Volckmar, A-L

“…Obesity is a relevant medical problem. Around 60 % of German adults are overweight, 20 % are obese. The hereditary contribution to the variance of body weight…”
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Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index by Dempfle, A, Hinney, A, Heinzel-Gutenbrunner, M, Raab, M, Geller, F, Gudermann, T, Schäfer, H, Hebebrand, J

“…The mean effect of each single mutation on the phenotype can only be estimated reliably from a large enough population or family based sample. Because most of…”
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Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA by Holzapfel, C, Grallert, H, Huth, C, Wahl, S, Fischer, B, Doring, A, Ruckert, I.M, Hinney, A, Hebebrand, J, Wichmann, H.E, Hauner, H, Illig, T, Heid, I.M

“…Background: Data from meta-analyses of genome-wide association studies provided evidence for an association of polymorphisms with body mass index (BMI), and…”
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Genetic aspects in attention-deficit/hyperactivity disorder by Albayrak, Ö., Friedel, S., Schimmelmann, B. G., Hinney, A., Hebebrand, J.

“…Summary Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder among children and adolescents with high heritability. Molecular…”
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Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys by Heid, I M, Vollmert, C, Hinney, A, Döring, A, Geller, F, Löwel, H, Wichmann, H-E, Illig, T, Hebebrand, J, Kronenberg, F

“…Background: The melanocortin-4-receptor gene (MC4R) is part of the melanocortinergic pathway that controls energy homeostasis. In a recent meta-analysis, the…”
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Comparison of metabolic profiles of acutely ill and short-term weight recovered patients with anorexia nervosa reveals alterations of 33 out of 163 metabolites by Föcker, M, Timmesfeld, N, Scherag, S, Knoll, N, Singmann, P, Wang-Sattler, R, Bühren, K, Schwarte, R, Egberts, K, Fleischhaker, C, Adamski, J, Illig, T, Suhre, K, Albayrak, Ö, Hinney, A, Herpertz-Dahlmann, B, Hebebrand, J

“…Abstract Starvation represents an extreme physiological state and entails numerous endocrine and metabolic adaptations. The large-scale application of…”
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Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder by Friedel, S., Fontenla Horro, F., Wermter, A.K., Geller, F., Dempfle, A., Reichwald, K., Smidt, J., Brönner, G., Konrad, K., Herpertz-Dahlmann, B., Warnke, A., Hemminger, U., Linder, M., Kiefl, H., Goldschmidt, H.P., Siegfried, W., Remschmidt, H., Hinney, A., Hebebrand, J.

“…Several lines of evidence indicate an involvement of brain derived neurotrophic factor (BDNF) in body weight regulation and activity: heterozygous Bdnf…”
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Association and linkage of allelic variants of the dopamine transporter gene in ADHD by FRIEDEL, S, SAAR, K, SCHERAG, A, WINDEMUTH -KIESELBACH, C, SCHIMMELMANN, B. G, WEWETZER, C, MEYER, J, WARNKE, A, LESCH, K. P, REINHARDT, R, HERPERTZ-DAHLMANN, B, LINDER, M, SAUER, S, HINNEY, A, REMSCHMIDT, H, SCHÄFER, H, KONRAD, K, HÜBNER, N, HEBEBRAND, J, DEMPFLE, A, WALITZA, S, RENNER, T, ROMANOS, M, FREITAG, C, SEITZ, C, PALMASON, H

“…Previously, we had reported a genome-wide scan for attention-deficit/hyperactivity disorder (ADHD) in 102 families with affected sibs of German ancestry; the…”
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Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention by Reinehr, T, Friedel, S, Mueller, T.D, Toschke, A.M, Hebebrand, J, Hinney, A

“…Objective: The T allele of the single-nucleotide polymorphism rs7903146 in TCF7L2 (transcription factor 7 like 2 gene) is associated with type 2 diabetes…”
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Perspectives: molecular genetic research in human obesity by Hebebrand, J., Friedel, S., Schäuble, N., Geller, F., Hinney, A.

“…Summary Within the past decade the molecular basis of single forms of monogenic obesity has been elucidated. With the exception of functionally relevant…”
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Association between an agouti-related protein gene polymorphism and anorexia nervosa by VINK, T, HINNEY, A, ADAN, R. A. H, VAN ELBURG, A. A, VAN GOOZEN, S. H. M, SANDKUIJL, L. A, SINKE, R. J, HERPERTZ-DAHLMANN, B-M, HEBEBRAND, J, REMSCHMIDT, H, VAN ENGELAND, H

“…Anorexia nervosa (AN) is a life threatening disorder affecting mostly adolescent women. It is a dramatic psychiatric syndrome accompanied by severe weight…”
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Systematic Mutation Screening of the Estrogen Receptor Beta Gene in Probands of Different Weight Extremes: Identification of Several Genetic Variants by Rosenkranz, K, Hinney, A, Ziegler, A, Hermann, H, Fichter, M, Mayer, H, Siegfried, W, Young, JK, Remschmidt, H, Hebebrand, J

“…Estrogens are known to have an inhibitory effect on food intake in rodents and primates. Decreased estrogen levels that are found for instance in menopausal…”
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