Search Results - "HILLARD, Cecilia J"

Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling by Patel, Sachin, Hillard, Cecilia J

“…Extracts of Cannabis sativa have been used for their calming and sedative effects for centuries. Recent developments in drug discovery have suggested that…”
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FAAH Inhibition Restores Early Life Stress-Induced Alterations in PFC microRNAs Associated with Depressive-Like Behavior in Male and Female Rats by Portugalov, Anna, Zaidan, Hiba, Gaisler-Salomon, Inna, Hillard, Cecilia J, Akirav, Irit

“…Early life stress (ELS) increases predisposition to depression. We compared the effects of treatment with the fatty acid amide hydrolase (FAAH) inhibitor…”
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Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation by Patel, Sachin, Hillard, Cecilia J.

“…Daily life stressors are a major environmental factor contributing to precipitation and exacerbation of mental illness. Animal models using repeated homotypic…”
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Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity by Segev, Amir, Korem, Nachshon, Mizrachi Zer-Aviv, Tomer, Abush, Hila, Lange, Rachel, Sauber, Garrett, Hillard, Cecilia J, Akirav, Irit

“…Posttraumatic stress disorder (PTSD) is characterized by the reexperiencing of a traumatic event and is associated with slower extinction of fear responses…”
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Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol by Hanlon, Erin C, Tasali, Esra, Leproult, Rachel, Stuhr, Kara L, Doncheck, Elizabeth, de Wit, Harriet, Hillard, Cecilia J, Van Cauter, Eve

“…Increasing evidence from laboratory and epidemiologic studies indicates that insufficient sleep may be a risk factor for obesity. Sleep curtailment results in…”
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Inhibition of an Equilibrative Nucleoside Transporter by Cannabidiol: A Mechanism of Cannabinoid Immunosuppression by Carrier, Erica J., Auchampach, John A., Hillard, Cecilia J.

“…The plant-derived cannabinoids Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD) both have immunosuppressive effects; although some effects of THC are…”
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Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior by Vickstrom, Casey R., Liu, Xiaojie, Liu, Shuai, Hu, Meng-Ming, Mu, Lianwei, Hu, Ying, Yu, Hao, Love, Santidra L., Hillard, Cecilia J., Liu, Qing-song

“…Enhancing endocannabinoid signaling produces anxiolytic- and antidepressant-like effects, but the neural circuits involved remain poorly understood. The medial…”
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Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala by Yasmin, Farhana, Colangeli, Roberto, Morena, Maria, Filipski, Sarah, van der Stelt, Mario, Pittman, Quentin J., Hillard, Cecilia J., Teskey, G. Campbell, McEwen, Bruce S., Hill, Matthew N., Chattarji, Sumantra

“…Even a brief exposure to severe stress strengthens synaptic connectivity days later in the amygdala, a brain area implicated in the affective symptoms of…”
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Circulating Endocannabinoids: From Whence Do They Come and Where are They Going? by Hillard, Cecilia J

“…The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to…”
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Fast Feedback Inhibition of the HPA Axis by Glucocorticoids Is Mediated by Endocannabinoid Signaling by Evanson, Nathan K, Tasker, Jeffrey G, Hill, Matthew N, Hillard, Cecilia J, Herman, James P

“…Glucocorticoid hormones are secreted in response to stimuli that activate the hypothalamo-pituitary-adrenocortical (HPA) axis and self-regulate through…”
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Contribution of the Adenosine 2A Receptor to Behavioral Effects of Tetrahydrocannabinol, Cannabidiol and PECS-101 by Stollenwerk, Todd M., Pollock, Samantha, Hillard, Cecilia J.

“…The cannabis-derived molecules, ∆9 tetrahydrocannabinol (THC) and cannabidiol (CBD), are both of considerable therapeutic interest for a variety of purposes,…”
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Endocannabinoid signaling in the etiology and treatment of major depressive illness by Hillard, Cecilia J, Liu, Qing-song

“…The purpose of this review is to examine human and preclinical data that are relevant to the following hypotheses. The first hypothesis is that deficient…”
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Endocannabinoid and psychological responses to acute resistance exercise in trained and untrained adults by Sirotiak, Zoe, Gallagher, Brandon T, Smith-Hernandez, Courtney A, Showman, Lucas J, Hillard, Cecilia J, Brellenthin, Angelique G

“…Introduction This study examined the effects of acute resistance exercise on circulating endocannabinoid (eCB) and mood responses in trained and untrained…”
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Endocannabinoid signaling in the central nervous system by Martinez Ramirez, César E., Ruiz‐Pérez, Gonzalo, Stollenwerk, Todd M., Behlke, Christina, Doherty, Ashley, Hillard, Cecilia J.

“…It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on central nervous system (CNS) function. In the 40 years since…”
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Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease by Lopez, Alicia, Aparicio, Noelia, Pazos, M. Ruth, Grande, M. Teresa, Barreda-Manso, M. Asuncion, Benito-Cuesta, Irene, Vazquez, Carmen, Amores, Mario, Ruiz-Pnrez, Gonzalo, Garcia-Garcia, Elena, Beatka, Margaret, Tolon, Rosa M, Dittel, Bonnie N, Hillard, Cecilia J, Romero, Julian

“…Background Because of their low levels of expression and the inadequacy of current research tools, CB2 cannabinoid receptors (CB2R) have been difficult to…”
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Signaling through the type 2 cannabinoid receptor regulates the severity of acute and chronic graft-versus-host disease by Yuan, Cheng Yin, Zhou, Vivian, Sauber, Garrett, Stollenwerk, Todd, Komorowski, Richard, López, Alicia, Tolón, Rosa María, Romero, Julian, Hillard, Cecilia J., Drobyski, William R.

“…Graft-versus-host disease (GVHD) pathophysiology is a complex interplay between cells that comprise the adaptive and innate arms of the immune system…”
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Endogenous cannabinoid signaling is essential for stress adaptation by Hill, Matthew N, McLaughlin, Ryan J, Bingham, Brenda, Shrestha, Lalita, Lee, Tiffany T.Y, Gray, J. Megan, Hillard, Cecilia J, Gorzalka, Boris B, Viau, Victor

“…Secretion of glucocorticoid hormones during stress produces an array of physiological changes that are adaptive and beneficial in the short term. In the face…”
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Circulating endocannabinoids and N -acyl ethanolamines are differentially regulated in major depression and following exposure to social stress by Hill, Matthew N, Miller, Gregory E, Carrier, Erica J, Gorzalka, Boris B, Hillard, Cecilia J

“…Summary Central endocannabinoid signaling is known to be responsive to stressful stimuli; however, there is no research to date characterizing the effects of…”
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peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome by Bowles, Nicole P., Karatsoreos, Ilia N., Li, Xiaosong, Vemuri, V. Kiran, Wood, Jodi-Anne, Li, Zhiying, Tamashiro, Kellie L. K., Schwartz, Gary J., Makriyannis, Alexandros M., Kunos, George, Hillard, Cecilia J., McEwen, Bruce S., Hill, Matthew N.

“…Significance Obesity and associated metabolic disorders (e.g., cardiovascular disease and type 2 diabetes) are major public health concerns. These disorders…”
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Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex by McReynolds, Jayme R., Doncheck, Elizabeth M., Li, Yan, Vranjkovic, Oliver, Graf, Evan N., Ogasawara, Daisuke, Cravatt, Benjamin F., Baker, David A., Liu, Qing-Song, Hillard, Cecilia J., Mantsch, John R.

“…Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become…”
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