Search Results - "HILL GASTON, J. S"

β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production by Elder, Matthew J, Webster, Steve J, Chee, Ronnie, Williams, David L, Hill Gaston, J S, Goodall, Jane C

“…Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production…”
Get full text

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection by Webster, Steve J, Brode, Sven, Ellis, Lou, Fitzmaurice, Timothy J, Elder, Matthew J, Gekara, Nelson O, Tourlomousis, Panagiotis, Bryant, Clare, Clare, Simon, Chee, Ronnie, Gaston, Hill J S, Goodall, Jane C

“…The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between…”
Get full text

Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules by Prevosto, Claudia, Usmani, M Farooq, McDonald, Sarah, Gumienny, Aleksandra M, Key, Tim, Goodman, Reyna S, Gaston, J S Hill, Deery, Michael J, Busch, Robert

“…Major histocompatibility complex class I (MHCI) glycoproteins present cytosolic peptides to CD8+ T cells and regulate NK cell activity. Their heavy chains (HC)…”
Get full text

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling by Elder, Matthew J, Webster, Steve J, Fitzmaurice, Timothy J, Shaunak, Aran S D, Steinmetz, Martin, Chee, Ronnie, Mallat, Ziad, Cohen, E Suzanne, Williams, David L, Gaston, J S Hill, Goodall, Jane C

“…Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous…”
Get full text

CD27 expression discriminates between regulatory and non‐regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells by Duggleby, Richard C., Shaw, Tovah N. F., Jarvis, Lorna B., Kaur, Gurman, Hill Gaston, J. S.

“…Summary It is clear that regulatory T cells (Treg) have an important role in preventing autoimmunity and modulating responses to pathogens. Full…”
Get full text

Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression by Goodall, Jane C., Wu, Changxin, Zhang, Yongsheng, McNeill, Louise, Ellis, Lou, Saudek, Vladimir, Gaston, J. S. Hill

“…The endoplasmic reticulum (ER) stress response detects malfunctions in cellular physiology, and microbial pattern recognition receptors recognize external…”
Get full text

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles by RAINE, T, BROWN, D, BOWNESS, P, HILL GASTON, J. S, MOFFETT, A, TROWSDALE, J, ALLEN, R. L

“…Major histocompatibility complex class I (MHC-I) proteins exist at the cell surface in antigen presenting forms and as beta2m-independent free heavy chains…”
Get full text

Regulatory IL4+CD8+ T cells in patients with ankylosing spondylitis and healthy controls by Zhang, L, Jarvis, L B, Baek, H-J, Gaston, J S Hill

“…Interleukin (IL)4+CD8+ regulatory T cells (Treg) obtained from peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS) by…”
Get more information

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis by Shen, Hui, Goodall, Jane C., Hill Gaston, J. S.

“…Objective To analyze the frequency, surface phenotype, and cytokine secretion of CD4+ T cells in peripheral blood mononuclear cells (PBMCs) from patients with…”
Get full text

PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans by Soond, Dalya R., Bjørgo, Elisa, Moltu, Kristine, Dale, Verity Q., Patton, Daniel T., Torgersen, Knut Martin, Galleway, Fiona, Twomey, Breda, Clark, Jonathan, Gaston, J. S. Hill, Taskén, Kjetil, Bunyard, Peter, Okkenhaug, Klaus

“…We have previously described critical and nonredundant roles for the phosphoinositide 3-kinase p110δ during the activation and differentiation of naive T…”
Get full text

Cytokine Secretion by Pathogen Recognition Receptor-stimulated Dendritic Cells in Rheumatoid Arthritis and Ankylosing Spondylitis by PREVOSTO, Claudia, GOODALL, Jane C, HILL GASTON, J. S

“…Interleukin 23 (IL-23) plays a major role in differentiation and survival of IL-17-secreting CD4+ Th17 cells. Having noted a higher frequency of Th17 cells in…”
Get full text

Frequency and Phenotype of T Helper 17 Cells in Peripheral Blood and Synovial Fluid of Patients with Reactive Arthritis by HUI SHEN, GOODALL, Jane C, GASTON, J. S. Hill

“…To analyze the frequency and phenotype of peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cell (SFMC) T helper (Th)17 cells in…”
Get full text

Rheumatic Diseases: Immunological Mechanisms and Prospects for New Therapies by Gaston, J. S. H

“…This authoritative review volume provides a wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases. Advances in our…”
Get full text

T cell recognition of a highly conserved epitope in heat shock protein 60: self‐tolerance maintained by TCR distinguishing between asparagine and aspartic acid by Lillicrap, Mark S., Duggleby, Richard C., Goodall, Jane C., Gaston, J. S. Hill

“…Cross‐reactive T cell recognition of self‐heat shock proteins (hsp) has been ascribed a regulatory role in inflammatory arthritis in both animal models and…”
Get full text

TSLP production by dendritic cells is modulated by IL-1[beta] and components of the endoplasmic reticulum stress response by Elder, Matthew J, Webster, Steven J, Williams, David L, Gaston, J S Hill, Goodall, Jane C

“…Thymic stromal lymphopoietin (TSLP) produced by epithelial cells acts on dendritic cells (DCs) to drive differentiation of TH2-cells, and is therefore…”
Get full text

TSLP production by dendritic cells is modulated by IL‐1β and components of the endoplasmic reticulum stress response by Elder, Matthew J., Webster, Steven J., Williams, David L., Gaston, J. S. Hill, Goodall, Jane C.

“…Thymic stromal lymphopoietin (TSLP) produced by epithelial cells acts on dendritic cells (DCs) to drive differentiation of TH2‐cells, and is therefore…”
Get full text

Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid by Van Krinks, C. H., Matyszak, M. K., Hill Gaston, J. S.

“…Objective. To examine the phenotype of dendritic cell subsets in synovial fluid and peripheral blood from patients with rheumatoid arthritis (RA) or…”
Get full text

Uptake and processing of Chlamydia trachomatis by human dendritic cells by Matyszak, Malgosia K., Young, Joyce L., Gaston, J. S. Hill

“…Chlamydia trachomatis (CT) causes several sexually transmitted diseases. In 2 – 5 % of cases, CT infection leads to the development of reactive arthritis…”
Get full text

Major histocompatibility complex class I‐restricted alloreactive CD4+ T cells by Boyle, Louise H., Goodall, Jane C., Gaston, J. S. Hill

“…Summary Although it is well established that CD4+ T cells generally recognize major histocompatibility complex (MHC) class II molecules, MHC class I‐reactive…”
Get full text

IRE1α mediates PKR activation in response to Chlamydia trachomatis infection by Webster, Steve J., Ellis, Lou, O'Brien, Louise M., Tyrrell, Beatrice, Fitzmaurice, Timothy J., Elder, Matthew J., Clare, Simon, Chee, Ronnie, Gaston, J.S. Hill, Goodall, Jane C.

“…Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However,…”
Get full text