Search Results - "HILL, Christopher P"

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4 by Han, Han, Hill, Christopher P

“…The progression of ESCRT (Endosomal Sorting Complexes Required for Transport) pathways, which mediate numerous cellular membrane fission events, is driven by…”
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Structural Biology of the Proteasome by Kish-Trier, Erik, Hill, Christopher P

“…The proteasome refers to a collection of complexes centered on the 20S proteasome core particle (20S CP), a complex of 28 subunits that houses proteolytic…”
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FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs by Kemble, David J., McCullough, Laura L., Whitby, Frank G., Formosa, Tim, Hill, Christopher P.

“…FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in…”
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Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase by Monroe, Nicole, Han, Han, Shen, Peter S, Sundquist, Wesley I, Hill, Christopher P

“…Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4…”
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Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase by VanderLinden, Ryan T., Hemmis, Casey W., Schmitt, Benjamin, Ndoja, Ada, Whitby, Frank G., Robinson, Howard, Cohen, Robert E., Yao, Tingting, Hill, Christopher P.

“…The UCH37 deubiquitylase functions in two large and very different complexes, the 26S proteasome and the INO80 chromatin remodeler. We have performed…”
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Vms1p is a release factor for the ribosome-associated quality control complex by Zurita Rendón, Olga, Fredrickson, Eric K., Howard, Conor J., Van Vranken, Jonathan, Fogarty, Sarah, Tolley, Neal D., Kalia, Raghav, Osuna, Beatriz A., Shen, Peter S., Hill, Christopher P., Frost, Adam, Rutter, Jared

“…Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to stall. The RQC…”
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The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets by Han, Han, Monroe, Nicole, Sundquist, Wesley I, Shen, Peter S, Hill, Christopher P

“…The hexameric AAA ATPase Vps4 drives membrane fission by remodeling and disassembling ESCRT-III filaments. Building upon our earlier 4.3 Å resolution cryo-EM…”
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Active conformation of the p97-p47 unfoldase complex by Xu, Yang, Han, Han, Cooney, Ian, Guo, Yuxuan, Moran, Noah G., Zuniga, Nathan R., Price, John C., Hill, Christopher P., Shen, Peter S.

“…The p97 AAA+ATPase is an essential and abundant regulator of protein homeostasis that plays a central role in unfolding ubiquitylated substrates. Here we…”
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The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II by Connell, Zaily, Parnell, Timothy J, McCullough, Laura L, Hill, Christopher P, Formosa, Tim

“…Abstract The conserved transcription elongation factor Spt6 makes several contacts with the RNA Polymerase II (RNAPII) complex, including a high-affinity…”
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Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism by VanderLinden, Ryan T., Hemmis, Casey W., Yao, Tingting, Robinson, Howard, Hill, Christopher P.

“…The 26S proteasome is a large cellular assembly that mediates the selective degradation of proteins in the nucleus and cytosol and is an established target for…”
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Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway by Cooney, Ian, Schubert, Heidi L., Cedeno, Karina, Fisher, Olivia N., Carson, Richard, Price, John C., Hill, Christopher P., Shen, Peter S.

“…The Cdc48 AAA+ ATPase is an abundant and essential enzyme that unfolds substrates in multiple protein quality control pathways. The enzyme includes two…”
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X-Ray Structures of the Hexameric Building Block of the HIV Capsid by Pornillos, Owen, Ganser-Pornillos, Barbie K., Kelly, Brian N., Hua, Yuanzi, Whitby, Frank G., Stout, C. David, Sundquist, Wesley I., Hill, Christopher P., Yeager, Mark

“…The mature capsids of HIV and other retroviruses organize and package the viral genome and its associated enzymes for delivery into host cells. The HIV capsid…”
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Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors by Rechsteiner, Martin, Hill, Christopher P.

“…Proteasomes perform the majority of proteolysis that occurs in the cytosol and nucleus of eukaryotic cells and, thereby, perform crucial roles in cellular…”
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ALIX-CHMP4 interactions in the human ESCRT pathway by McCullough, John, Fisher, Robert D, Whitby, Frank G, Sundquist, Wesley I, Hill, Christopher P

“…The ESCRT pathway facilitates membrane fission events during enveloped virus budding, multivesicular body formation, and cytokinesis. To promote HIV budding…”
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Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria by Nielson, Jason R., Fredrickson, Eric K., Waller, T. Cameron, Rendón, Olga Zurita, Schubert, Heidi L., Lin, Zhenjian, Hill, Christopher P., Rutter, Jared

“…Vms1 translocates to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mitochondrial protein homeostasis…”
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Same structure, different mechanisms? by Tsai, Francis TF, Hill, Christopher P

“…Two interpretations of similar structures for the same molecular machine illustrate the limits of inferring biochemical mechanism from protein structure…”
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Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites by Espino-Sanchez, Tanya J, Wienkers, Henry, Marvin, Rebecca G, Nalder, Shai-anne, García-Guerrero, Aldo E, Vannatta, Peter E, Jami-Alahmadi, Yasaman, Blackwell, Amanda Mixon, Whitby, Frank G, Wohlschlegel, James A, Kieber-Emmons, Matthew T, Hill, Christopher P, Sigala, Paul A

“…The mitochondrial electron transport chain (ETC) of Plasmodium malaria parasites is a major antimalarial drug target, but critical cytochrome (cyt) functions…”
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A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription by Sdano, Matthew A, Fulcher, James M, Palani, Sowmiya, Chandrasekharan, Mahesh B, Parnell, Timothy J, Whitby, Frank G, Formosa, Tim, Hill, Christopher P

“…We determined that the tandem SH2 domain of Spt6 binds the linker region of the RNA polymerase II subunit Rpb1 rather than the expected sites in its heptad…”
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Potent D-peptide inhibitors of HIV-1 entry by Welch, Brett D, VanDemark, Andrew P, Heroux, Annie, Hill, Christopher P, Kay, Michael S

“…During HIV-1 entry, the highly conserved gp41 N-trimer pocket region becomes transiently exposed and vulnerable to inhibition. Using mirror-image phage display…”
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Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions by Song, Aixin, Hazlett, Zachary, Abeykoon, Dulith, Dortch, Jeremy, Dillon, Andrew, Curtiss, Justin, Martinez, Sarah Bollinger, Hill, Christopher P, Yu, Clinton, Huang, Lan, Fushman, David, Cohen, Robert E, Yao, Tingting

“…UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme (DUB) that associates with the 26S proteasome. Recently, it was reported that UCH37…”
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