Search Results - "HILL, A. V. S"

New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human and Simian Adenoviral Vectors and Poxviral Vectors Expressing an Optimized Antigen Based on Merozoite Surface Protein 1 by Goodman, Anna L, Epp, C, Moss, D, Holder, A.A, Wilson, J.M, Gao, G.P, Long, C.A, Remarque, E.J, Thomas, A.W, Ammendola, V, Colloca, S, Dicks, M.D.J, Biswas, S, Seibel, D, van Duivenvoorde, L.M, Gilbert, S.C, Hill, A.V.S, Draper, S.J

“…Although merozoite surface protein 1 (MSP-1) is a leading candidate vaccine antigen for blood-stage malaria, its efficacy in clinical trials has been limited…”
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Single-Dose Protection against Plasmodium berghei by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A by SRIDHAR, S, REYES-SANDOVAL, A, DRAPER, S. J, MOORE, A. C, GILBERT, S. C, GAO, G. P, WILSON, J. M, HILL, A. V. S

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Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women by Naranbhai, V, de Assis Rosa, D, Werner, L, Moodley, R, Hong, H, Kharsany, A, Mlisana, K, Sibeko, S, Garrett, N, Chopera, D, Carr, W H, Abdool Karim, Q, Hill, A V S, Abdool Karim, S S, Altfeld, M, Gray, C M, Ndung'u, T

“…Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen (HLA) to modify natural killer- and T-cell function. KIR are implicated…”
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Tuberculosis and Chronic Hepatitis B Virus Infection in Africans and Variation in the Vitamin D Receptor Gene by Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Thursz, M., Whittle, H. C., Hill, A. V. S.

“…The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulatory hormone [1]. Its effects are exerted by interaction with the…”
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Boosting with Poxviruses Enhances Mycobacterium bovis BCG Efficacy against Tuberculosis in Guinea Pigs by Williams, A, Goonetilleke, N. P, McShane, H, Clark, Simon O, Hatch, Graham, Gilbert, S. C, Hill, A. V. S

“…Tuberculosis is rising in the developing world due to poor health care, human immunodeficiency virus type 1 infection, and the low protective efficacy of the…”
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Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum by Kapulu, M. C., Da, D. F., Miura, K., Li, Y, Blagborough, A. M., Churcher, T. S., Nikolaeva, D., Williams, A. R., Goodman, A. L., Sangare, I., Turner, A. V., Cottingham, M. G., Nicosia, A., Straschil, U., Tsuboi, T., Gilbert, S. C., Long, Carole A., Sinden, R. E., Draper, S. J., Hill, A. V. S., Cohuet, A., Biswas, S.

“…Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium parasites within the mosquito, with the aim of preventing malaria…”
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Establishment of an Aerosol Challenge Model of Tuberculosis in Rhesus Macaques and an Evaluation of Endpoints for Vaccine Testing by Sharpe, S A, McShane, H, Dennis, M J, Basaraba, R J, Gleeson, F, Hall, G, McIntyre, A, Gooch, K, Clark, S, Beveridge, N E R, Nuth, E, White, A, Marriott, A, Dowall, S, Hill, A V S, Williams, A, Marsh, P D

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Tumor Necrosis Factor Promoter Polymorphism and Susceptibility to Lepromatous Leprosy by Roy, S., McGuire, W., Mascie-Taylor, C. G. N., Saha, B., Hazra, S. K., Hill, A. V. S., Kwiatkowski, D.

“…Genetically determined differences in immune responses to environmental agents may underlie susceptibility to many autoimmune and infectious diseases. Leprosy…”
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DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge by Dunachie, S.J, Walther, M, Epstein, J.E, Keating, S, Berthoud, T, Andrews, L, Andersen, R.F, Bejon, P, Goonetilleke, N, Poulton, I, Webster, D.P, Butcher, G, Watkins, K, Sinden, R.E, Levine, G.L, Richie, T.L, Schneider, J, Kaslow, D, Gilbert, S.C, Carucci, D.J, Hill, A.V.S

“…The safety, immunogenicity, and efficacy of DNA and modified vaccinia virus Ankara (MVA) prime-boost regimes were assessed by using either…”
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Prevalence of serum neutralizing antibodies against chimpanzee adenovirus 63 and human adenovirus 5 in Kenyan Children, in the context of vaccine vector efficacy by Dudareva, M, Andrews, L, Gilbert, S.C, Bejon, P, Marsh, K, Mwacharo, J, Kai, O, Nicosia, A, Hill, A.V.S

“…Abstract Vaccination against Plasmodium falciparum malaria could reduce the worldwide burden of this disease, and decrease its high mortality in children…”
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Substantially Reduced Pre-patent Parasite Multiplication Rates Are Associated With Naturally Acquired Immunity to "Plasmodium falciparum" by Douglas, A. D., Andrews, L., Draper, S. J., Bojang, K., Milligan, P., Gilbert, S. C., Imoukhuede, E. B., Hill, A. V. S.

“…Naturally acquired immunity to Plasmodium falciparum's asexual blood stage reduces parasite multiplication at microscopically detectable densities. The effect…”
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Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR by KNAPP, S, YEE, L. J, HILL, A. V. S, THURSZ, M. R, FRODSHAM, A. J, HENNIG, B. J. W, HELLIER, S, ZHANG, L, WRIGHT, M, CHIARAMONTE, M, GRAVES, M, THOMAS, H. C

“…Interferon stimulates the expression of a number of genes encoding enzymes with antiviral activities, including myxovirus resistance-1 (MxA),…”
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Association of Vitamin D Receptor Genotype with Leprosy Type by Roy, S., Frodsham, A., Saha, B., Hazra, S. K., Mascie-Taylor, C. G. N., Hill, A.V. S.

“…Host genetic factors including major histocompatibility complex (MHC) polymorphisms influence both susceptibility to leprosy per se and also to leprosy type…”
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NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations by Chapman, S J, Khor, C C, Vannberg, F O, Rautanen, A, Segal, S, Moore, C E, Davies, R J O, Day, N P, Peshu, N, Crook, D W, Berkley, J A, Williams, T N, Scott, J A, Hill, A V S

“…The proinflammatory transcription factor nuclear factor-κB (NF-κB) has a central role in host defence against pneumococcal disease. Both rare mutations and…”
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Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria by Ruwende, C, Khoo, S. C, Snow, R. W, Yates, S. N. R, Kwiatkowski, D, Gupta, S, Warn, P, Allsopp, C. E. M, Gilbert, S. C, Peschu, N, Newbold, C. I, Greenwood, B. M, Marsh, K, Hill, A. V. S

“…Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy of humans, affects over 400 million people. The geographical correlation of…”
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Naturally Exposed Populations Differ in Their T1 and T2 Responses to the Circumsporozoite Protein of Plasmodium falciparum by REECE, W. H. H, PLEBANSKI, M, AKINWUNMI, P, GOTHARD, P, FLANAGAN, K. L, LEE, E. A. M, CORTINA-BORJA, M, HILL, A. V. S, PINDER, M

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Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi‐immune adults in The Gambia by PINDER, M., REECE, W. H. H., PLEBANSKI, M., AKINWUNMI, P., FLANAGAN, K. L., LEE, E. A. M., DOHERTY, T., MILLIGAN, P., JAYE, A., TORNIEPORTH, N., BALLOU, R., MCADAM, K. P. M. J., COHEN, J., HILL, A. V. S.

“…SUMMARY Vaccination of malaria‐naive humans with recombinant RTS,S/AS02, which includes the C‐terminus of the circumsporozoite protein (CS), has been shown to…”
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High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene by Lipscombe, R J, Sumiya, M, Hill, A V, Lau, Y L, Levinsky, R J, Summerfield, J A, Turner, M W

“…We have previously identified, in three British families having an index child with frequent infections, a point mutation (GGC-->GAC) in codon 54 of exon 1 of…”
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Human genomics of the humoral immune response against polyomaviruses by Hodel, F, Chong, A Y, Scepanovic, P, Xu, Z M, Naret, O, Thorball, C W, Rüeger, S, Marques-Vidal, P, Vollenweider, P, Begemann, M, Ehrenreich, H, Brenner, N, Bender, N, Waterboer, T, Mentzer, A J, Hill, A V S, Hammer, C, Fellay, J

“…Abstract Human polyomaviruses are widespread in humans and can cause severe disease in immunocompromised individuals. To identify human genetic determinants of…”
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T cells in peripheral blood after gluten challenge in coeliac disease by Anderson, R P, van Heel, D A, Tye-Din, J A, Barnardo, M, Salio, M, Jewell, D P, Hill, A V S

“…Background: Current understanding of T cell epitopes in coeliac disease (CD) largely derives from intestinal T cell clones in vitro. T cell clones allow…”
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