Search Results - "HILKE, J"

Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma by Spahn, Stephan, Roessler, Daniel, Pompilia, Radu, Gabernet, Gisela, Gladstone, Beryl Primrose, Horger, Marius, Biskup, Saskia, Feldhahn, Magdalena, Nahnsen, Sven, Hilke, Franz J, Scheiner, Bernhard, Dufour, Jean-François, De Toni, Enrico N, Pinter, Matthias, Malek, Nisar P, Bitzer, Michael

“…Immune checkpoint inhibitors (ICIs) belong to the therapeutic armamentarium in advanced hepatocellular carcinoma (HCC). However, only a minority of patients…”
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The prevalence of Dichelobacter nodosus in clinically footrot-free sheep flocks: a comparative field study on elimination strategies by Kraft, A F, Strobel, H, Hilke, J, Steiner, A, Kuhnert, P

“…Ovine footrot caused by Dichelobacter nodosus (D nodosus) is an infectious disease affecting sheep worldwide. Switzerland plans a nationwide footrot…”
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Travellers’ preferences towards existing and emerging means of first/last mile transport: a case study for the Almere centrum railway station in the Netherlands by Stam, Bas, van Oort, Niels, van Strijp-Harms, Hilke J., van der Spek, Stefan C., Hoogendoorn, Serge P.

“…First/last mile transport is essential for transit but is often found to be the weakest link in a trip. Moreover, as a result of multiple developments (e.g…”
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Structural control, hydrothermal alteration zonation, and fluid chemistry of the concealed, high-grade 4EE iron orebody at the Paraburdoo 4E Deposit, Hamersley Province, Western Australia by Thorne, Warren S, Hagemann, Steffen G, Sepe, David, Dalstra, Hilke J, Banks, David A

“…High-grade iron ore of the 4EE orebody of the 4E deposit (>200 Mt at 63.5 wt % Fe) occurs as a southerly dipping sheet within banded iron formation (BIF) of…”
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Prospective multicenter study using artificial intelligence to improve dermoscopic melanoma diagnosis in patient care by Heinlein, Lukas, Maron, Roman C., Hekler, Achim, Haggenmüller, Sarah, Wies, Christoph, Utikal, Jochen S., Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F., Sergon, Mildred, Hauschild, Axel, French, Lars E., Heinzerling, Lucie, Schlager, Justin G., Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J., Poch, Gabriela, Korsing, Sören, Berking, Carola, Heppt, Markus V., Erdmann, Michael, Haferkamp, Sebastian, Drexler, Konstantin, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Krieghoff-Henning, Eva, Brinker, Titus J.

“…Background Early detection of melanoma, a potentially lethal type of skin cancer with high prevalence worldwide, improves patient prognosis. In retrospective…”
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Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma by Löffler, Markus W, Mohr, Christopher, Bichmann, Leon, Freudenmann, Lena Katharina, Walzer, Mathias, Schroeder, Christopher M, Trautwein, Nico, Hilke, Franz J, Zinser, Raphael S, Mühlenbruch, Lena, Kowalewski, Daniel J, Schuster, Heiko, Sturm, Marc, Matthes, Jakob, Riess, Olaf, Czemmel, Stefan, Nahnsen, Sven, Königsrainer, Ingmar, Thiel, Karolin, Nadalin, Silvio, Beckert, Stefan, Bösmüller, Hans, Fend, Falko, Velic, Ana, Maček, Boris, Haen, Sebastian P, Buonaguro, Luigi, Kohlbacher, Oliver, Stevanović, Stefan, Königsrainer, Alfred, Rammensee, Hans-Georg

“…Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular…”
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First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications by Löffler, Markus W, Steinhilber, Julia, Hilke, Franz J, Haen, Sebastian P, Bösmüller, Hans, Montes-Mojarro, Ivonne-Aidee, Bonzheim, Irina, Stäbler, Antje, Faust, Ulrike, Grasshoff, Ute, Königsrainer, Ingmar, Rammensee, Hans-Georg, Kanz, Lothar, Königsrainer, Alfred, Beckert, Stefan, Riess, Olaf, Schroeder, Christopher

“…The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several…”
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Dynamics of cell-free tumour DNA correlate with treatment response of head and neck cancer patients receiving radiochemotherapy by Hilke, Franz J., Muyas, Francesc, Admard, Jakob, Kootz, Beate, Nann, Dominik, Welz, Stefan, Rieß, Olaf, Zips, Daniel, Ossowski, Stephan, Schroeder, Christopher, Clasen, Kerstin

“…•ctDNA can be detected in the majority of patients with locally advanced HNSCC.•ctDNA was correlated with gross tumour volume before treatment…”
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Explainable artificial intelligence in skin cancer recognition: A systematic review by Hauser, Katja, Kurz, Alexander, Haggenmüller, Sarah, Maron, Roman C., von Kalle, Christof, Utikal, Jochen S., Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F., Sergon, Mildred, Hauschild, Axel, French, Lars E., Heinzerling, Lucie, Schlager, Justin G., Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J., Poch, Gabriela, Kutzner, Heinz, Berking, Carola, Heppt, Markus V., Erdmann, Michael, Haferkamp, Sebastian, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Kather, Jakob N., Fröhling, Stefan, Lipka, Daniel B., Hekler, Achim, Krieghoff-Henning, Eva, Brinker, Titus J.

“…Due to their ability to solve complex problems, deep neural networks (DNNs) are becoming increasingly popular in medical applications. However, decision-making…”
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Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification by Höhn, Julia, Krieghoff-Henning, Eva, Jutzi, Tanja B., von Kalle, Christof, Utikal, Jochen S., Meier, Friedegund, Gellrich, Frank F., Hobelsberger, Sarah, Hauschild, Axel, Schlager, Justin G., French, Lars, Heinzerling, Lucie, Schlaak, Max, Ghoreschi, Kamran, Hilke, Franz J., Poch, Gabriela, Kutzner, Heinz, Heppt, Markus V., Haferkamp, Sebastian, Sondermann, Wiebke, Schadendorf, Dirk, Schilling, Bastian, Goebeler, Matthias, Hekler, Achim, Fröhling, Stefan, Lipka, Daniel B., Kather, Jakob N., Krahl, Dieter, Ferrara, Gerardo, Haggenmüller, Sarah, Brinker, Titus J.

“…Clinicians and pathologists traditionally use patient data in addition to clinical examination to support their diagnoses. We investigated whether a…”
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A benchmark for neural network robustness in skin cancer classification by Maron, Roman C., Schlager, Justin G., Haggenmüller, Sarah, von Kalle, Christof, Utikal, Jochen S., Meier, Friedegund, Gellrich, Frank F., Hobelsberger, Sarah, Hauschild, Axel, French, Lars, Heinzerling, Lucie, Schlaak, Max, Ghoreschi, Kamran, Hilke, Franz J., Poch, Gabriela, Heppt, Markus V., Berking, Carola, Haferkamp, Sebastian, Sondermann, Wiebke, Schadendorf, Dirk, Schilling, Bastian, Goebeler, Matthias, Krieghoff-Henning, Eva, Hekler, Achim, Fröhling, Stefan, Lipka, Daniel B., Kather, Jakob N., Brinker, Titus J.

“…One prominent application for deep learning–based classifiers is skin cancer classification on dermoscopic images. However, classifier evaluation is often…”
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The Janus kinase 1 inhibitor abrocitinib for the treatment of oral lichen planus by Solimani, Farzan, Mesas‐Fernández, Alberto, Dilling, Amrei, Nast, Alexander, Hilke, Franz J., Ghoreschi, Franziska C., Worm, Margitta, Ghoreschi, Kamran, Meier, Katharina

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Circulating cell-free DNA: A potential biomarker to differentiate inflammation and infection during radiochemotherapy by Zwirner, Kerstin, Hilke, Franz J., Demidov, German, Ossowski, Stephan, Gani, Cihan, Rieß, Olaf, Zips, Daniel, Welz, Stefan, Schroeder, Christopher

“…•Elevated cfDNA levels were associated with PEG placement and antibiotic treatment.•CfDNA might differentiate radiation-induced toxicity and severe…”
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Distinct Mutation Patterns Reveal Melanoma Subtypes and Influence Immunotherapy Response in Advanced Melanoma Patients by Hilke, Franz J., Sinnberg, Tobias, Gschwind, Axel, Niessner, Heike, Demidov, German, Amaral, Teresa, Ossowski, Stephan, Bonzheim, Irina, Röcken, Martin, Riess, Olaf, Garbe, Claus, Schroeder, Christopher, Forschner, Andrea

“…The detection of somatic driver mutations by next-generation sequencing (NGS) is becoming increasingly important in the care of advanced melanoma patients. In…”
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Federated Learning for Decentralized Artificial Intelligence in Melanoma Diagnostics by Haggenmüller, Sarah, Schmitt, Max, Krieghoff-Henning, Eva, Hekler, Achim, Maron, Roman C, Wies, Christoph, Utikal, Jochen S, Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F, Sergon, Mildred, Hauschild, Axel, French, Lars E, Heinzerling, Lucie, Schlager, Justin G, Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J, Poch, Gabriela, Korsing, Sören, Berking, Carola, Heppt, Markus V, Erdmann, Michael, Haferkamp, Sebastian, Drexler, Konstantin, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Kather, Jakob N, Fröhling, Stefan, Brinker, Titus J

“…The development of artificial intelligence (AI)-based melanoma classifiers typically calls for large, centralized datasets, requiring hospitals to give away…”
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Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient by Löffler, Markus W, Chandran, P. Anoop, Laske, Karoline, Schroeder, Christopher, Bonzheim, Irina, Walzer, Mathias, Hilke, Franz J, Trautwein, Nico, Kowalewski, Daniel J, Schuster, Heiko, Günder, Marc, Carcamo Yañez, Viviana A, Mohr, Christopher, Sturm, Marc, Nguyen, Huu-Phuc, Riess, Olaf, Bauer, Peter, Nahnsen, Sven, Nadalin, Silvio, Zieker, Derek, Glatzle, Jörg, Thiel, Karolin, Schneiderhan-Marra, Nicole, Clasen, Stephan, Bösmüller, Hans, Fend, Falko, Kohlbacher, Oliver, Gouttefangeas, Cécile, Stevanović, Stefan, Königsrainer, Alfred, Rammensee, Hans-Georg

“…Graphical abstract…”
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Using multiple real-world dermoscopic photographs of one lesion improves melanoma classification via deep learning by Hekler, Achim, Maron, Roman C., Haggenmüller, Sarah, Schmitt, Max, Wies, Christoph, Utikal, Jochen S., Meier, Friedegund, Hobelsberger, Sarah, Gellrich, Frank F., Sergon, Mildred, Hauschild, Axel, French, Lars E., Heinzerling, Lucie, Schlager, Justin G., Ghoreschi, Kamran, Schlaak, Max, Hilke, Franz J., Poch, Gabriela, Korsing, Sören, Berking, Carola, Heppt, Markus V., Erdmann, Michael, Haferkamp, Sebastian, Drexler, Konstantin, Schadendorf, Dirk, Sondermann, Wiebke, Goebeler, Matthias, Schilling, Bastian, Kather, Jakob N., Krieghoff-Henning, Eva, Brinker, Titus J.

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Radiogenomics in head and neck cancer: correlation of radiomic heterogeneity and somatic mutations in TP53, FAT1 and KMT2D by Zwirner, Kerstin, Hilke, Franz J., Demidov, German, Socarras Fernandez, Jairo, Ossowski, Stephan, Gani, Cihan, Thorwarth, Daniela, Riess, Olaf, Zips, Daniel, Schroeder, Christopher, Welz, Stefan

“…Purpose Genetic tumour profiles and radiomic features can be used to complement clinical information in head and neck squamous cell carcinoma (HNSCC) patients…”
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Clinical and immunological impact of booster immunization with recombinant mRNA vaccines for SARS‐CoV‐2 in patients with pemphigus and bullous pemphigoid by Solimani, F., Mesas‐Fernández, A., Bodner, E., Carevic‐Neri, M., Hasheminasab, M., Jakovljevicova, T., Philipp, A., Nast, A., Worm, M., Hilke, F. J., Meier, K., Ghoreschi, K.

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A comprehensive quality control workflow for paired tumor-normal NGS experiments by Schroeder, Christopher M, Hilke, Franz J, Löffler, Markus W, Bitzer, Michael, Lenz, Florian, Sturm, Marc

“…Quality control (QC) is an important part of all NGS data analysis stages. Many available tools calculate QC metrics from different analysis steps of single…”
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