Search Results - "HILDINGER, M"

Isolation and evaluation of novel adeno-associated virus sequences from porcine tissues by Bello, A, Tran, K, Chand, A, Doria, M, Allocca, M, Hildinger, M, Beniac, D, Kranendonk, C, Auricchio, A, Kobinger, G P

“…High antigenic compatibility and low toxicity is associated with xenograft transplantation of porcine tissues in immunodeficient human recipients. We…”
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Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column by Auricchio, A, Hildinger, M, O'Connor, E, Gao, G P, Wilson, J M

“…One of the most promising gene transfer vectors in human clinical trials is AAV2. The quality of the vector preparations is a key element in obtaining reliable…”
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Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer by Hildinger, M, Auricchio, A, Gao, G, Wang, L, Chirmule, N, Wilson, J M

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Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy by Reich, S J, Auricchio, A, Hildinger, M, Glover, E, Maguire, A M, Wilson, J M, Bennett, J

“…Recombinant vectors based on adeno-associated virus (AAV) can efficiently transduce many different cell types, including cells of the retina, resulting in…”
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Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry by Hildinger, M, Dittmar, M T, Schult-Dietrich, P, Fehse, B, Schnierle, B S, Thaler, S, Stiegler, G, Welker, R, von Laer, D

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Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer by CMEJLOVA, J, HILDINGER, M, CMEJLA, R, FUCHS, O, KALABOVA, D, BAUM, C, JELINEK, J

“…The multidrug resistance 1 (MDR1) gene transfer to hematopoietic cells for protection against cytotoxic drugs has received considerable attention in gene…”
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Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells by KNIPPER, R, KUEHLCKE, K, ECKERT, H.-G, BAUM, C, SCHIEDLMEIER, B, HILDINGER, M, LINDEMANN, C, SCHILZ, A. J, FAUSER, A. A, FRUEHAUF, S, ZELLER, W. J, OSTERTAG, W

“…We describe the functional analysis of a novel retroviral vector, SF91m3, which was designed for improved expression of the in vivo selectable marker,…”
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FMEV vectors : both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells by HILDINGER, M, ECKERT, H.-G, SCHILZ, A. T, JOHN, T, OSTERTAG, W, BAUM, C

“…FMEV retroviral vectors combine the long terminal repeat of Friend mink cell focus-forming viruses with the 5' untranslated leader region of the murine…”
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Lack of superinfection interference in retroviral vector producer cells by Vogt, B, Roscher, S, Abel, B, Hildinger, M, Lamarre, A, Baum, C, von Laer, D

“…Vesicular stomatitis virus G protein (VSV-G)-pseudotyped retroviral vectors have become more feasible for clinical gene transfer protocols since stable…”
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Bicistronic retroviral vectors for combining myeloprotection with cell-surface marking by HILDINGER, M, SCHILZ, A, ECKERT, H.-G, BOHN, W, FEHSE, B, ZANDER, A. R, OSTERTAG, W, BAUM, C

“…We have developed a retroviral vector coexpressing the multidrug-resistance 1 (MDR1) cDNA for inducing cancer drug resistance and the truncated version of the…”
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RNA Interference–Mediated Suppression and Replacement of Human Rhodopsin In Vivo by O’Reilly, Mary, Palfi, Arpad, Chadderton, Naomi, Millington-Ward, Sophia, Ader, Marius, Cronin, Thérèse, Tuohy, Thérèse, Auricchio, Alberto, Hildinger, Markus, Tivnan, Amanda, McNally, Niamh, Humphries, Marian M., Kiang, Anna-Sophia, Humphries, Pete, Kenna, Paul F., Farrar, G. Jane

“…Mutational heterogeneity represents a significant barrier to development of therapies for many dominantly inherited diseases. For example, >100 mutations in…”
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Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model by Auricchio, A, Kobinger, G, Anand, V, Hildinger, M, O'Connor, E, Maguire, A M, Wilson, J M, Bennett, J

“…Recombinant vectors based on adeno-associated virus (AAV) or human immunodeficiency 1 (lentivirus) are promising tools for long term in vivo gene delivery…”
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cis-Active elements of Friend spleen focus-forming virus: from disease induction to disease prevention by Baum, C, Hunt, N, Hildinger, M, Eckert, H G, Zaehres, H, Richters, A, John, J, Löhler, J, Ostertag, W

“…The polycythemic strain of the Friend spleen focus-forming virus (SFFVp) is a replication-defective, acutely transforming retrovirus inducing a bistage…”
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Advances in AAV-mediated gene transfer for the treatment of inherited disorders by HILDINGER, Markus, AURICCHIO, Alberto

“…The holy grail of gene therapy is the cure of genetic diseases. To achieve this goal, a vector system is desirable that offers a high level of safety combined…”
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Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors by Schambach, Axel, Wodrich, Harald, Hildinger, Markus, Bohne, Jens, Kräusslich, Hans-Georg, Baum, Christopher

“…We present a systematic comparison of three modules that enhance expression from retroviral gene transfer vectors at a posttranscriptional level: (i) splice…”
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Design of 5′ Untranslated Sequences in Retroviral Vectors Developed for Medical Use by Hildinger, M, Abel, K L, Ostertag, W, Baum, C

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A Single-Step Affinity Column for Purification of Serotype-5 Based Adeno-associated Viral Vectors by Auricchio, Alberto, O'Connor, Erin, Hildinger, Markus, Wilson, James M.

“…Here we describe a single-step affinity column for purification of vectors based on adeno-associated virus type 5 (AAV5). A sialic-acid-rich protein called…”
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Adiponectin receptors sustain hematopoietic stem cells throughout adulthood by protecting them from inflammation by Meacham, Corbin E., Jeffery, Elise C., Burgess, Rebecca J., Sivakumar, Charukesi D., Arora, Madison A., Stanley, Anne Marie, Hildinger, Emily M., Crane, Genevieve M., Zhao, Zhiyu, Morrison, Sean J.

“…How are hematopoietic stem cells (HSCs) protected from inflammation, which increases with age and can deplete HSCs? Adiponectin, an anti-inflammatory factor…”
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In vivo quantitative noninvasive imaging of gene transfer by single-photon emission computerized tomography by Auricchio, Alberto, Acton, Paul D, Hildinger, Markus, Louboutin, Jean-Pierre, Plössl, Karl, O'Connor, Erin, Kung, Hank F, Wilson, James M

“…Systems aimed at detecting gene expression noninvasively in vivo are desirable for evaluating the outcome of gene transfer in clinical trials. Several…”
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Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents by Rappa, G, Lorico, A, Hildinger, M, Fodstad, Ø, Baum, C

“…We have constructed two retroviral vectors, one expressing multidrug resistance protein 1 (MRP1) alone (SF91MRP) and the other expressing MRP1 and…”
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