Search Results - "HIGHLEY, M"

Gemcitabine alone or in combination with cisplatin in patients with advanced or metastatic cholangiocarcinomas or other biliary tract tumours: a multicentre randomised phase II study - The UK ABC-01 Study by Valle, J W, Wasan, H, Johnson, P, Jones, E, Dixon, L, Swindell, R, Baka, S, Maraveyas, A, Corrie, P, Falk, S, Gollins, S, Lofts, F, Evans, L, Meyer, T, Anthoney, A, Iveson, T, Highley, M, Osborne, R, Bridgewater, J

“…Background: We assessed the activity of gemcitabine (G) and cisplatin/gemcitabine (C/G) in patients with locally advanced (LA) or metastatic (M) (advanced)…”
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Estimation of glomerular filtration rate in cancer patients by WRIGHT, J. G, BODDY, A. V, HIGHLEY, M, FENWICK, J, MCGILL, A, CALVERT, A. H

“…The frequent need to obtain an estimate of renal function in cancer patients, not least for targeting carboplatin dose, has led to a number of approaches to…”
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A phase II study of capecitabine and oxaliplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract by Graham, J S, Boyd, K, Coxon, F Y, Wall, L R, Eatock, M M, Maughan, T S, Highley, M, Soulis, E, Harden, S, Bützberger-Zimmerli, P, Evans, T R J

“…Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study…”
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433 Decrease of pro-angiogenic monocytes predicts clinical response to anti-angiogenic treatment in patients with metastatic renal cell carcinoma (mRCC) by Oudard, S, Benhamouda, N, Escudier, B, Ravel, P, Kothari, D, Mehmud, F, Levionnois, E, Sevin, E, Negrier, S, Barthelemy, P, Berdah, J.F, Ravaud, A, Sternberg, C.N, Bono, P, Porta, C, Giorgi, U. De, Parikh, O, Hawkins, R, Highley, M, Tartour, E, Decker, T, Wilkie, J

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Treatment of Invasive Thymoma With Single-Agent Ifosfamide by HIGHLEY, M. S, UNDERHILL, C. R, HARPER, P. G, PARNIS, F. X, KARAPETIS, C, RANKIN, E, DUSSEK, J, BRYANT, B, ROWLAND, C, HODSON, N, HUGHES, J

“…To evaluate single-agent ifosfamide in the treatment of invasive thymoma. Fifteen patients (eight male and seven female) with histologically confirmed invasive…”
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Interaction between paclitaxel and warfarin by Thompson, M. E., Highley, M. S.

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Hyphenated techniques in anticancer drug monitoring: II. Liquid chromatography–mass spectrometry and capillary electrophoresis–mass spectrometry by Guetens, G, De Boeck, G, Highley, M.S, Wood, M, Maes, R.A.A, Eggermont, A.A.M, Hanauske, A, de Bruijn, E.A, Tjaden, U.R

“…High-performance liquid chromatography has become the separation technique of choice for the monitoring of generally thermolabile anticancer agents. With the…”
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Weekly cisplatin with oral etoposide: a well-tolerated and highly effective regimen in relapsed ovarian cancer by Verborg, W A, Campbell, L R, Highley, M S, Rankin, E M

“…The optimal treatment of progressive ovarian cancer after first-line platinum-based therapy remains a challenge. We collected prospectively data on patients…”
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Phase I study of TNFα AutoVaccIne in Patients with metastatic cancer by Waterston, A. M., Gumbrell, L., Bratt, T., Waller, S., Gustav-Aspland, J., L‘Hermenier, C, Bellenger, K, Campbell, M, Powles, T, Highley, M, Bower, M, Mouritsen, S., Feldmann, M., Coombes, R. C.

“…We evaluated the safety and immunogencity of a novel vaccine directed against autologous TNFα in a Phase I fixed dose escalation trial. The vaccine consisted…”
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Hyphenated techniques in anticancer drug monitoring: I. Capillary gas chromatography–mass spectrometry by Guetens, G, De Boeck, G, Wood, M, Maes, R.A.A, Eggermont, A.A.M, Highley, M.S, van Oosterom, A.T, de Bruijn, E.A, Tjaden, U.R

“…Most anticancer agents are relatively unstable substances and are subjected to intensive metabolism in vivo and degradation during sample pretreatment…”
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A Phase II Trial of Continuous 5-Fluorouracil in Recurrent or Metastatic Transitional Cell Carcinoma of the Urinary Tract by Highley, M.S, Griffiths, G.O, Uscinska, B.M, Huddart, R.A, Barber, J.B.P, Parmar, M.K.B, Harper, P.G

“…Abstract Aims To assess the activity of a continuous infusion of 5-fluorouracil in patients with recurrent locally advanced or metastatic transitional cell…”
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Nanotechnology in bio/clinical analysis by Guetens, G, Van Cauwenberghe, K, De Boeck, G, Maes, R, Tjaden, U.R, van der Greef, J, Highley, M, van Oosterom, A.T, de Bruijn, E.A

“…Nanotechnology is being exploited now in different fields of analytical chemistry: Single cell analysis; in chip/micro machined devices; hyphenated technology…”
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Erythrocytes and the transport of drugs and endogenous compounds by HIGHLEY, M. S, DE BRUIJN, E. A

“…This review considers the significance and measurement of endogenous compounds and drugs on erythrocytes. Part I examines literature examples where a direct…”
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Intravesical drug delivery : Pharmacokinetic and clinical considerations by HIGHLEY, M. S, VAN OOSTEROM, A. T, MAES, R. A, DE BRUIJN, E. A

“…Intravesical drug administration is widely used in the treatment of patients with superficial bladder cancer, and aims to optimise drug delivery in the…”
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Activated oxazaphosphorines are transported predominantly by erythrocytes by Highley, M. S., Schrijvers, D., Van Oosterom, A. T., Harper, P. G., Momerency, G., Van Cauwenberghe, K., Maes, R. A. A., De Bruijn, E. A., Edelstein, M. B.

“…purpose Oxazaphosphorines are metabolised by a variety of pathways, one of which leads to activation and the formation of alkylating compounds. However, the…”
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The impact of drug administration sequence and pharmacokinetic interaction in a phase I study of the combination of docetaxel and gemcitabine in patients with advanced solid tumors by Dumez, H, Louwerens, M, Pawinsky, A, Planting, ASTh, de Jonge, MJA, Van Oosterom, AT, Highley, M, Guetens, G, Mantel, M, De Boeck, G, de Bruijn, E, Verweij, J

“…Our objective was to determine the maximum tolerated dose (MTD) of two administration sequences of docetaxel and gemcitabine in cancer patients, and to…”
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Multicenter phase II study of gemcitabine in previously untreated patients with advanced epithelial ovarian cancer by Underhill, C R, Parnis, F X, Highley, M S, Ahern, J, Harper, P G, Hansen, H, Lund, B, Dombernowsky, P, Hirsch, F, Hansen, M, Carmichael, J, Williams, C

“…Gemcitabine has activity in advanced ovarian cancer, with responses in platinum-resistant disease. This study assessed the activity of gemcitabine in…”
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Combination chemotherapy with epirubicin, cisplatin and 5-fluorouracil for the palliation of advanced gastric and oesophageal adenocarcinoma by Highley, M S, Parnis, F X, Trotter, G A, Houston, S J, Penson, R T, Harper, P G, Mason, R C

“…The palliative efficacy of laser therapy with combination chemotherapy (cisplatin, epirubicin and continuous infusion of 5-fluorouracil) was assessed in 34…”
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Pharmacokinetics and bioavailability of oral 5′‐deoxy‐5‐fluorouridine in cancer patients by VAN DER HEYDEN, S. A. M, HIGHLEY, M. S, DE BRUIJN, E. A, TJADEN, U. R, REEUWIJK, H. J. E. M, VAN SLOOTEN, H, OOSTEROM, A. T. V, MAES, R. A. A

“…Aims Oral administration of 5‐fluorouracil (FUra), an important cytotoxic agent, is limited by a wide variation in bioavailability. 5′‐deoxy‐5‐fluorouridine…”
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Preferential location of circulating activated cyclophosphamide within the erythrocyte by Highley, M S, Harper, P G, Slee, P H, DeBruijn, E

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