Search Results - "HIGASHIMOTO, Yuichiro"

RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy by Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Nakamura, Nobutaka, Fukami, Kei, Yamagishi, Sho-Ichi

“…The interaction of advanced glycation end products (AGEs) and their receptor (RAGE) plays a central role in diabetic nephropathy. We screened DNA aptamers…”
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Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase by Sugishima, Masakazu, Sato, Hideaki, Higashimoto, Yuichiro, Harada, Jiro, Wada, Kei, Fukuyama, Keiichi, Noguchi, Masato

“…NADPH-cytochrome P450 oxidoreductase (CPR) supplies electrons to various heme proteins including heme oxygenase (HO), which is a key enzyme for heme…”
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DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing Receptors for Advanced Glycation End Product-Induced Oxidative Stress and Inflammation in the Testes of Diabetic Mice by Mori, Yusaku, Terasaki, Michishige, Osaka, Naoya, Fujikawa, Tomoki, Yashima, Hironori, Saito, Tomomi, Kataoka, Yurie, Ohara, Makoto, Higashimoto, Yuichiro, Matsui, Takanori, Yamagishi, Sho-Ichi

“…Type 2 diabetes mellitus (T2DM) is a risk factor for male infertility, but the underlying molecular mechanisms remain unclear. Advanced glycation end products…”
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SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis by Terasaki, Michishige, Shibata, Keita, Mori, Yusaku, Saito, Tomomi, Matsui, Takanori, Ohara, Makoto, Fukui, Tomoyasu, Hasumi, Keiji, Higashimoto, Yuichiro, Nobe, Koji, Yamagishi, Sho-Ichi

“…SMTP-44D has been reported to have anti-oxidative and anti-inflammatory reactions, including reduced expression of receptor for advanced glycation end products…”
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Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction by Sotokawauchi, Ami, Nakamura, Nobutaka, Matsui, Takanori, Higashimoto, Yuichiro, Yamagishi, Sho-Ichi

“…Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) contribute to proximal tubulopathy in diabetes. However, what glycer-AGE structure could…”
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Fructose causes endothelial cell damage via activation of advanced glycation end products-receptor system by Sotokawauchi, Ami, Matsui, Takanori, Higashimoto, Yuichiro, Yamagishi, Sho-Ichi

“…Advanced glycation end products and their receptor - RAGE - in the adipose tissues contribute to metabolic derangements in fructose-fed rats. However, it…”
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RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice by Nakamura, Nobutaka, Matsui, Takanori, Ishibashi, Yuji, Sotokawauchi, Ami, Fukami, Kei, Higashimoto, Yuichiro, Yamagishi, Sho-Ichi

“…Epidemiological studies have suggested the link between cumulative diabetic exposure and cancer. Interaction of advanced glycation end products (AGEs) with…”
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Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor by Taira, Junichi, Higashimoto, Yuichiro

“…Growth factor receptor-bound protein 14 (Grb14) interacts with insulin receptor (IR) through the between PH and SH2 (BPS) domain. Grb14-IR complex formation is…”
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Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor by Taira, Junichi, Kida, Yutaka, Inatomi, Kohei, Komatsu, Hideyuki, Higashimoto, Yuichiro, Sakamoto, Hiroshi

“…Growth factor receptor-bound protein 14 (Grb14) is a negative regulator of insulin receptor (IR) and is involved in a negative feedback mechanism of insulin…”
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Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension by Nakamura, Kazufumi, Sakaguchi, Masakiyo, Matsubara, Hiromi, Akagi, Satoshi, Sarashina, Toshihiro, Ejiri, Kentaro, Akazawa, Kaoru, Kondo, Megumi, Nakagawa, Koji, Yoshida, Masashi, Miyoshi, Toru, Ogo, Takeshi, Oto, Takahiro, Toyooka, Shinichi, Higashimoto, Yuichiro, Fukami, Kei, Ito, Hiroshi

“…Pulmonary vascular remodeling of pulmonary arterial hypertension (PAH) is characterized by an inappropriate increase of vascular cells. The receptor for…”
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Laminin receptor mediates anti-inflammatory and anti-thrombogenic effects of pigment epithelium-derived factor in myeloma cells by Matsui, Takanori, Higashimoto, Yuichiro, Yamagishi, Sho-ichi

“…•PEDF decreased VEGF, MCP-1, ICAM-1 and PAI-1 mRNA levels in myeloma cells.•The effects of PEDF on myeloma cells were abolished by LR knockdown.•LR-Ab or LR…”
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DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice by Ojima, Ayako, Matsui, Takanori, Maeda, Sayaka, Takeuchi, Masayoshi, Inoue, Hiroyoshi, Higashimoto, Yuichiro, Yamagishi, Sho-ichi

“…Epidemiological studies have suggested that diabetes is associated with an increased risk of cancer. However, the underlying molecular mechanism remains…”
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RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice by Taguchi, Kensei, Yamagishi, Sho-ichi, Yokoro, Miyuki, Ito, Sakuya, Kodama, Goh, Kaida, Yusuke, Nakayama, Yosuke, Ando, Ryotaro, Yamada-Obara, Nana, Asanuma, Katsuhiko, Matsui, Takanori, Higashimoto, Yuichiro, Brooks, Craig R., Ueda, Seiji, Okuda, Seiya, Fukami, Kei

“…The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end…”
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DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice by Sotokawauchi, Ami, Matsui, Takanori, Higashimoto, Yuichiro, Nishino, Yuri, Koga, Yoshinori, Yagi, Minoru, Yamagishi, Sho-ichi

“…Objective: Interaction of advanced glycation end products (AGEs) with the receptor RAGE plays a role in diabetic nephropathy. However, effects of RAGE-aptamer…”
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Advanced glycation end products evoke inflammatory reactions in proximal tubular cells via autocrine production of dipeptidyl peptidase-4 by Kaifu, Kumiko, Ueda, Seiji, Nakamura, Nobutaka, Matsui, Takanori, Yamada-Obara, Nana, Ando, Ryotaro, Kaida, Yusuke, Nakata, Masami, Matsukuma-Toyonaga, Maki, Higashimoto, Yuichiro, Fukami, Kei, Suzuki, Yusuke, Okuda, Seiya, Yamagishi, Sho-ichi

“…We have previously shown that albuminuria and renal levels of advanced glycation end products (AGEs), receptor for AGEs (RAGE), and oxidative stress are…”
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Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1 by Taira, Junichi, Kida, Yutaka, Kuwano, Koichi, Higashimoto, Yuichiro

“…High mobility group box 1 (HMGB1), a non-histone chromosomal protein, is a proinflammatory cytokine. There are two known pathways for the release of HMGB1 into…”
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Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells by Matsui, Takanori, Higashimoto, Yuichiro, Taira, Junichi, Yamagishi, Sho-ichi

“…•PEDF bound to caveolin-1 (Cav).•One of the major Cav-interacting proteins in human serum was identified as PEDF.•Cav evoked inflammatory reactions in…”
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Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats by Nakamura, Kazufumi, Akagi, Satoshi, Ejiri, Kentaro, Yoshida, Masashi, Miyoshi, Toru, Sakaguchi, Masakiyo, Amioka, Naofumi, Suastika, Luh Oliva Saraswati, Kondo, Megumi, Nakayama, Rie, Takaya, Yoichi, Higashimoto, Yuichiro, Fukami, Kei, Matsubara, Hiromi, Ito, Hiroshi

“…•RAGE-aptamer suppresses development of monocrotaline-induced pulmonary arterial hypertension (PAH) in rats.•Inhibition of RAGE ameliorates muscularization of…”
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Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice by Mori, Yusaku, Ohara, Makoto, Terasaki, Michishige, Osaka, Naoya, Yashima, Hironori, Saito, Tomomi, Otoyama-Kataoka, Yurie, Omachi, Takemasa, Higashimoto, Yuichiro, Matsui, Takanori, Fukui, Tomoyasu, Yamagishi, Sho-Ichi

“…We have developed DNA aptamers that can inhibit the toxic effects of advanced glycation end products (AGE-Apts). We herein evaluated the effects of AGE-Apts on…”
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Long-Term Local Injection of RAGE-Aptamer Suppresses the Growth of Malignant Melanoma in Nude Mice by Higashimoto, Yuichiro, Sotokawauchi, Ami, Nishino, Yuri, Matsui, Takanori, Nakamura, Nobutaka, Yamagishi, Sho-ichi

“…Accumulating evidence has suggested the pathological role of advanced glycation end products (AGEs) and their receptor RAGE axis in aging-associated disorders,…”
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