Search Results - "HICKEY, Deirdre M. B"

The discovery of GSK221149A: A potent and selective oxytocin antagonist by Liddle, John, Allen, Michael J., Borthwick, Alan D., Brooks, David P., Davies, David E., Edwards, Richard M., Exall, Anne M., Hamlett, Chris, Irving, Wendy R., Mason, Andrew M., McCafferty, Gerald P., Nerozzi, Fabrizio, Peace, Simon, Philp, Joanne, Pollard, Derek, Pullen, Mark A., Shabbir, Shaila S., Sollis, Steve L., Westfall, Timothy D., Woollard, Pat M., Wu, Charlene, Hickey, Deirdre M.B.

“…Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has…”
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Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor by McKeown, Stephen C., Corbett, David F., Goetz, Aaron S., Littleton, Thomas R., Bigham, Eric, Briscoe, Celia P., Peat, Andrew J., Watson, Steve P, Hickey, Deirdre M.B.

“…The discovery, solid phase synthesis and structure–activity relationships of novel carboxylic acid agonists for the GPR40 receptor are described. The…”
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Synthesis and properties of macrolones characterized by two ether bonds in the linker by Jakopović, Ivana Palej, Kragol, Goran, Forrest, Andrew K., Frydrych, Catherine S.V., Štimac, Vlado, Kapić, Samra, Škugor, Maja Matanović, Ilijaš, Marina, Paljetak, Hana Čipčić, Jelić, Dubravko, Holmes, David J., Hickey, Deirdre M.B., Verbanac, Donatella, Eraković Haber, Vesna, Alihodžić, Sulejman

“…In this paper synthesis of macrolones 1– 18 starting from azithromycin is reported. Two key steps in the construction of the linker between macrolide and…”
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Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat by McCafferty, Gerald P, Pullen, Mark A, Wu, Charlene, Edwards, Richard M, Allen, Michael J, Woollard, Patrick M, Borthwick, Alan D, Liddle, John, Hickey, Deirdre M B, Brooks, David P, Westfall, Timothy D

“…Spontaneous and induced uterine contractions in the rat were found to be inhibited by a novel and selective oxytocin receptor antagonist GSK221149A…”
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5-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Garland, Stephen L, Hickey, Deirdre M.B, Ife, Robert J, Liddle, John, Saunders, Martin, Smith, David G, Ward, Robert W

“…A novel series of pyrazolo[3,4- b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3). A novel series of…”
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The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2 by BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H

“…Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant lipoprotein-associated…”
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5-Aryl-pyrazolo[3,4- b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) by Witherington, Jason, Bordas, Vincent, Haigh, David, Hickey, Deirdre M.B, Ife, Robert J, Rawlings, Anthony D, Slingsby, Brian P, Smith, David G, Ward, Robert W

“…Introduction of a nitrogen atom into the 6-position of a series of pyrazolo[3,4- b]pyridines led to a dramatic improvement in the potency of GSK-3 inhibition…”
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Inhibitors of CoA-independent transacylase block the movement of arachidonate into 1-ether-linked phospholipids of human neutrophils by Chilton, Floyd H, Fonteh, Alfred N, Sung, Chiu-Mei, Hickey, Deirdre M. B, Torphy, Theodore J, Mayer, Ruth J, Marshall, Lisa A, Heravi, Javid D, Winkler, James D

“…The enzyme CoA-independent transacylase (CoA-IT) has been proposed to mediate the movement of arachidonate between phospholipid subclasses and influence the…”
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor by MACPHEE, Colin H., MOORES, Kitty E., BOYD, Helen F., DHANAK, Dash, IFE, Robert J., LEACH, Colin A., LEAKE, David S., MILLINER, Kevin J., PATTERSON, Rebecca A., SUCKLING, Keith E., TEW, David G., HICKEY, Deirdre M. B.

“…A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is…”
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man by BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones by BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2 by BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man by Blackie, Josie A, Bloomer, Jackie C, Brown, Murray J B, Cheng, Hung-Yuan, Elliott, Richard L, Hammond, Beverley, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Lewis, V Ann, Macphee, Colin H, Milliner, Kevin J, Moores, Kitty E, Pinto, Ivan L, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Taylor, Maxine A, Theobald, Colin J, Whittaker, Caroline M

“…The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant…”
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 by BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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Lipoprotein-associated PLA2 inhibition : a novel, non-lipid lowering strategy for atherosclerosis therapy by LEACH, Colin A, HICKEY, Deirdre M. B, IFE, Robert J, MACPHEE, Colin H, SMITH, Stephen A, TEW, David G

“…Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a serine lipase that is associated with low density lipoprotein (LDL) in human plasma. Substrates include…”
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BASE INDUCED REACTION OF AN AZETIDIN-2-ONE: FORMATION OF A NOVEL [1,4]-DIAZEPINEDIONE by Dhanak, Dashyant, Hickey, Deirdre M. B., Meeson, Malcolm L., Elliott, Richard L., Shore, Andrew D., Haltiwanger, R. Curtis

“…A mild, base mediated conversion of an azetidin-2-one to the [1,4]-diazapinedione system is reported and a putative mechanistic pathway is proposed…”
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SK&F 97426-A: a novel bile acid sequestrant with higher affinities and slower dissociation rates for bile acids in vitro than cholestyramine by Benson, G M, Alston, D R, Hickey, D M, Jaxa-Chamiec, A A, Whittaker, C M, Haynes, C, Glen, A, Blanchard, S, Cresswell, S R, Suckling, K E

“…SK&F 97426-A is a novel bile acid sequestrant that is threefold more potent than cholestyramine at increasing bile acid excretion in the hamster. SK&F 97426-A…”
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