Search Results - "HICKEY, D. M. B"

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound by Forbes, Ian T, Cooper, David G, Dodds, Emma K, Hickey, Deirdre M.B, Ife, Robert J, Meeson, Malcolm, Stockley, Martin, Berkhout, Theo A, Gohil, Jayneeta, Groot, Pieter H.E, Moores, Kitty

“…A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is…”
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Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514 by PINTO, I. L, BOYD, H. F, HICKEY, D. M. B

“…The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), is described together…”
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2-(alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 by BOYD, H. F, FLYNN, S. T, SMITH, S. A, STANSFIELD, I. G, TEW, D. G, THEOBALD, C. J, HICKEY, D. M. B, IFE, R. J, JONES, M, LEACH, C. A, MACPHEE, C. H, MILLINER, K. J, RAWLINGS, D. A, SLINGSBY, B. P

“…Starting from two weakly active hits from high throughput screening, a novel series of 2-(alkylthio)-pyrimidin-4-ones with high potency and selectivity for…”
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SK&F 97426-A: a novel bile acid sequestrant with higher affinities and slower dissociation rates for bile acids in vitro than cholestyramine by Benson, G M, Alston, D R, Hickey, D M, Jaxa-Chamiec, A A, Whittaker, C M, Haynes, C, Glen, A, Blanchard, S, Cresswell, S R, Suckling, K E

“…SK&F 97426-A is a novel bile acid sequestrant that is threefold more potent than cholestyramine at increasing bile acid excretion in the hamster. SK&F 97426-A…”
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Octimibate, a potent non‐prostanoid inhibitor of platelet aggregation, acts via the prostacyclin receptor by Merritt, Janet E., Hallam, Trevor J., Brown, Anthony M., Boyfield, Isobel, Cooper, David G., Hickey, Deirdre M.B., Jaxa‐Chamiec, Albert A., Kaumann, Alberto J., Keen, Mary, Kelly, Eamonn, Kozlowski, Ursula, Lynham, James A., Moores, Kitty E., Murray, Kenneth J., MacDermot, John, Rink, Timothy J.

“…1 Octimibate, 8‐[(1,4,5‐triphenyl‐1H‐imidazol‐2‐yl)oxy]octanoic acid, is reported to have antithrombotic properties. This is in addition to its…”
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SK&F 97426-A a more potent bile acid sequestrant and hypocholesterolaemic agent than cholestyramine in the hamster by Benson, G M, Alston, D R, Bond, B C, Gee, A N, Glen, A, Haynes, C, Hickey, D M, Iqbal, S, Jackson, B, Jaxa-Chamiec, A A

“…SK&F 97426-A is a novel bile acid sequestrant which was selected for comparison with cholestyramine in vivo because of its superior in vitro bile acid binding…”
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Azidocinnamates in heterocyclic synthesis by Hickey, D M. B

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Precipitation and 13C-NMR relaxation enhancement measurements of the interactions of bile acids with synthetic cationic bile acid derivatives, and with spin labelled fatty acids by Reid, D G, Gajjar, K, Robinson, S P, Hickey, D M, Benson, G M, Haynes, C, Leeson, P D, Whittaker, C M

“…In an investigation of novel potential bile acid sequestrants, the affinities of the sodium salts of the glycine and taurine conjugates of naturally occurring…”
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