Search Results - "HIBBS, Martin J."

Discovery and Biochemical Characterization of Plasmodium Thioredoxin Reductase Inhibitors from an Antimalarial Set by Theobald, Andrew J, Caballero, Iván, Coma, Isabel, Colmenarejo, Gonzalo, Cid, Concepcion, Gamo, Francisco-Javier, Hibbs, Martin J, Bass, Amy L, Thomas, Daniel A

“…Plasmodium falciparum is the most prevalent and deadly species of the human malaria parasites, and thioredoxin reductase (TrxR) is an enzyme involved in the…”
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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase by Brown, Murray J., Carter, Paul S., Fenwick, Ashley E., Fosberry, Andrew P., Hamprecht, Dieter W., Hibbs, Martin J., Jarvest, Richard L., Mensah, Lucy, Milner, Peter H., O'Hanlon, Peter J., Pope, Andrew J., Richardson, Christine M., West, Andrew, Witty, David R.

“…The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A…”
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High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay by Singh, Praveen K., Chan, Pan F., Hibbs, Martin J., Vazquez, Maria-Jesus, Segura, Delfina C., Thomas, Daniel A., Theobald, Andrew J., Gallagher, Kathleen T., Hassan, Namir J.

“…DNA topoisomerase type II enzymes are well-validated targets of anti-bacterial and anti-cancer compounds. In order to facilitate discovery of these types of…”
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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens by JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela

“…Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized…”
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Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase by Jarvest, Richard L., Erskine, Symon G., Forrest, Andrew K., Fosberry, Andrew P., Hibbs, Martin J., Jones, Joanna J., O’Hanlon, Peter J., Sheppard, Robert J., Worby, Angela

“…High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified an ethanolamine as a sub-micromolar hit. Optimisation studies…”
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Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat by Pratt, JR, Hibbs, MJ, Laver, AJ, Smith, RA, Sacks, SH

“…Complement is both an effector of the humoral immune response and a stimulator of leukocyte activation. To examine the influence of complement on the allograft…”
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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens by Jarvest, Richard L, Berge, John M, Berry, Valerie, Boyd, Helen F, Brown, Murray J, Elder, John S, Forrest, Andrew K, Fosberry, Andrew P, Gentry, Daniel R, Hibbs, Martin J, Jaworski, Deborah D, O'Hanlon, Peter J, Pope, Andrew J, Rittenhouse, Stephen, Sheppard, Robert J, Slater-Radosti, Courtney, Worby, Angela

“…Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized…”
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Development of an insect-cell-based assay for detection of kinase inhibition using NF-kappaB-inducing kinase as a paradigm by Hassan, Namir J, Gul, Sheraz, Flett, Fiona, Hollingsworth, Edward, Dunne, Angela A, Emmons, Amanda J, Hutchinson, Jonathan P, Hibbs, Martin J, Dyos, Susan, Kitson, Jeremy D, Hiley, Emma, Rüdiger, Martin, Tew, David G, Powell, David J, Morse, Mary A

“…Identification of small-molecule inhibitors by high-throughput screening necessitates the development of robust, reproducible and cost-effective assays. The…”
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Reduction of myocardial reperfusion injury with human soluble complement receptor type 1 (BRL 55730) by Smith, 3rd, E F, Griswold, D E, Egan, J W, Hillegass, L M, Smith, R A, Hibbs, M J, Gagnon, R C

“…This study was designed to evaluate the cardioprotective effects of a solubilized human complement receptor, sCR1, in the rat subjected to myocardial…”
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