Search Results - "HIAI, Hiroshi"

PD-1 deficiency results in the development of fatal myocarditis in MRL mice by Wang, Jian, Okazaki, Il-mi, Yoshida, Taku, Chikuma, Shunsuke, Kato, Yu, Nakaki, Fumio, Hiai, Hiroshi, Honjo, Tasuku, Okazaki, Taku

“…The deficiency of programmed cell death 1 (PD-1, Pdcd1), a negative immuno-receptor belonging to the CD28/cytotoxic T lymphocyte antigen 4 (CTLA-4) family, can…”
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Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice by Matsuo, Junichi, Kimura, Shunichi, Yamamura, Akihiro, Koh, Cai Ping, Hossain, Md Zakir, Heng, Dede Liana, Kohu, Kazuyoshi, Voon, Dominic Chih-Cheng, Hiai, Hiroshi, Unno, Michiaki, So, Jimmy Bok Yan, Zhu, Feng, Srivastava, Supriya, Teh, Meng, Yeoh, Khay Guan, Osato, Motomi, Ito, Yoshiaki

“…Background & Aims Little is known about the mechanisms of gastric carcinogenesis, partly because it has been a challenge to identify characterize gastric stem…”
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Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases by Mashimo, Tomoji, Takizawa, Akiko, Voigt, Birger, Yoshimi, Kazuto, Hiai, Hiroshi, Kuramoto, Takashi, Serikawa, Tadao

“…Although the rat is extensively used as a laboratory model, the inability to utilize germ line-competent rat embryonic stem (ES) cells has been a major…”
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Establishment of NOD-Pdcd1-/-Mice as an Efficient Animal Model of Type I Diabetes by Wang, Jian, Yoshida, Taku, Nakaki, Fumio, Hiai, Hiroshi, Okazaki, Taku, Honjo, Tasuku

“…Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family,…”
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Increased Intratumor Vα24-Positive Natural Killer T Cells: A Prognostic Factor for Primary Colorectal Carcinomas by Tachibana, Tsuyoshi, Onodera, Hisashi, Tsuruyama, Tatsuaki, Mori, Akira, Nagayama, Satoshi, Hiai, Hiroshi, Imamura, Masayuki

“…Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte populations with a restricted T-cell receptor repertoire (Vα24-Vβ11). They…”
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Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut Flora by Fagarasan, Sidonia, Muramatsu, Masamichi, Suzuki, Keiichiro, Nagaoka, Hitoshi, Hiai, Hiroshi, Honjo, Tasuku

“…Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin…”
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Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice by Honjo, Tasuku, Okazaki, Taku, Tanaka, Yoshimasa, Nishio, Ryosuke, Mitsuiye, Tamotsu, Mizoguchi, Akira, Wang, Jian, Ishida, Masayoshi, Hiai, Hiroshi, Matsumori, Akira, Minato, Nagahiro

“…We recently reported that mice deficient in the programmed cell death-1 (PD-1) immunoinhibitory coreceptor develop autoimmune dilated cardiomyopathy (DCM),…”
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Involvement of activation-induced cytidine deaminase in skin cancer development by Nonaka, Taichiro, Toda, Yoshinobu, Hiai, Hiroshi, Uemura, Munehiro, Nakamura, Motonobu, Yamamoto, Norio, Asato, Ryo, Hattori, Yukari, Bessho, Kazuhisa, Minato, Nagahiro, Kinoshita, Kazuo

“…Most skin cancers develop as the result of UV light-induced DNA damage; however, a substantial number of cases appear to occur independently of UV damage. A…”
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Constitutive expression of AID leads to tumorigenesis by Okazaki, Il-mi, Hiai, Hiroshi, Kakazu, Naoki, Yamada, Shuichi, Muramatsu, Masamichi, Kinoshita, Kazuo, Honjo, Tasuku

“…Genome stability is regulated by the balance between efficiencies of the repair machinery and genetic alterations such as mutations and chromosomal…”
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Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice by Nishimura, Hiroyuki, Okazaki, Taku, Tanaka, Yoshimasa, Nakatani, Kazuki, Hara, Masatake, Matsumori, Akira, Sasayama, Shigetake, Mizoguchi, Akira, Hiai, Hiroshi, Minato, Nagahiro, Honjo, Tasuku

“…Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory…”
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Inhibition of gastric inhibitory polypeptide signaling prevents obesity by Seino, Yutaka, Miyawaki, Kazumasa, Yamada, Yuichiro, Ban, Nobuhiro, Ihara, Yu, Tsukiyama, Katsushi, Zhou, Heying, Fujimoto, Shimpei, Oku, Akira, Tsuda, Kinsuke, Toyokuni, Shinya, Hiai, Hiroshi, Mizunoya, Wataru, Fushiki, Tohru, Holst, Jens Juul, Makino, Mitsuhiro, Tashita, Akira, Kobara, Yukari, Tsubamoto, Yoshiharu, Jinnouchi, Takayoshi, Jomori, Takahito

“…Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of…”
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Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice by Wada, Kenta, Matsushima, Yoshibumi, Tada, Tomoki, Hasegawa, Sayaka, Obara, Yo, Yoshizawa, Yasuhiro, Takahashi, Gou, Hiai, Hiroshi, Shimanuki, Midori, Suzuki, Sari, Saitou, Junichi, Yamamoto, Naoki, Ichikawa, Masumi, Watanabe, Kei, Kikkawa, Yoshiaki

“…Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development…”
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Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer by Kitamura, Jiro, Uemura, Munehiro, Kurozumi, Mafumi, Sonobe, Makoto, Manabe, Toshiaki, Hiai, Hiroshi, Date, Hiroshi, Kinoshita, Kazuo

“…Activation-induced cytidine deaminase (AID) is an enzyme required for antibody diversification, and it causes DNA mutations and strand breaks. Constitutive AID…”
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Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine by Kayahara, Takahisa, Sawada, Mitsutaka, Takaishi, Shigeo, Fukui, Hirokazu, Seno, Hiroshi, Fukuzawa, Hiroaki, Suzuki, Katsumasa, Hiai, Hiroshi, Kageyama, Ryoichiro, Okano, Hideyuki, Chiba, Tsutomu

“…Musashi-1, a neural RNA-binding protein, is important for maintaining neural stem cells. Both Musashi-1 and Hes1, a transcriptional factor regulated by…”
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Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene by Mori, Masayuki, Gotoh, Saki, Taketani, Shigeru, Hiai, Hiroshi, Higuchi, Keiichi

“…The Nakano cataract (NCT) is a recessive disorder in the mouse linked to the nct locus on chromosome 16. In this study, we positionally cloned the critical…”
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The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells by Eguchi, Koichi, Yoshioka, Yasuhide, Yoshida, Hideki, Morishita, Kazushige, Miyata, Seiji, Hiai, Hiroshi, Yamaguchi, Masamitsu

“…The Drosophila sponge (spg)/CG31048 gene belongs to the dedicator of cytokinesis (DOCK) family genes that are conserved in a wide variety of species. DOCK…”
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Generation and Characterization of Severe Combined Immunodeficiency Rats by Mashimo, Tomoji, Takizawa, Akiko, Kobayashi, Junya, Kunihiro, Yayoi, Yoshimi, Kazuto, Ishida, Saeko, Tanabe, Koji, Yanagi, Ami, Tachibana, Asato, Hirose, Jun, Yomoda, Jun-ichiro, Morimoto, Shiho, Kuramoto, Takashi, Voigt, Birger, Watanabe, Takeshi, Hiai, Hiroshi, Tateno, Chise, Komatsu, Kenshi, Serikawa, Tadao

“…Severe combined immunodeficiency (SCID) mice, the most widely used animal model of DNA-PKcs (Prkdc) deficiency, have contributed enormously to our…”
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Correction: Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer by Kitamura, Jiro, Uemura, Munehiro, Kurozumi, Mafumi, Sonobe, Makoto, Manabe, Toshiaki, Hiai, Hiroshi, Date, Hiroshi, Kinoshita, Kazuo

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Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis by TANAKA, Tomoyuki, AKATSUKA, Shinya, OZEKI, Munetaka, SHIRASE, Tomoyuki, HIAI, Hiroshi, TOYOKUNI, Shinya

“…Ferric nitrilotriacetate (Fe-NTA) induces oxidative renal damage leading to a high incidence of renal cell carcinoma (RCC) in rats. Differential display…”
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Persistent oxidative stress in cancer by Toyokuni, Shinya, Okamoto, Keisei, Yodoi, Junji, Hiai, Hiroshi

“…DNA of cancers such as renal cell carcinoma and mammary invasive ductal carcinoma, is persistently exposed to more oxidative stress than that of adjacent…”
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