Search Results - "HETHERINGTON, Seth"

Genetic variations in HLA-B region and hypersensitivity reactions to abacavir by Hetherington, Seth, Hughes, Arlene R, Mosteller, Michael, Shortino, Denise, Baker, Katherine L, Spreen, William, Lai, Eric, Davies, Kirstie, Handley, Abigail, Dow, David J, Fling, Mary E, Stocum, Michael, Bowman, Clive, Thurmond, Linda M, Roses, Allen D

“…Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify…”
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Clinical Trial of Safety and Efficacy of IHN-A21 for the Prevention of Nosocomial Staphylococcal Bloodstream Infection in Premature Infants by DeJonge, Mitchell, MD, Burchfield, David, MD, Bloom, Barry, MD, Duenas, Maria, MD, Walker, Whit, MD, Polak, Mark, MD, Jung, Elizabeth, MD, Millard, Dietra, MD, Schelonka, Robert, MD, Eyal, Fabien, MD, Morris, Amy, MBA, Kapik, Barry, MS, Roberson, Destrey, RN, Kesler, Karen, PhD, Patti, Joe, PhD, Hetherington, Seth, MD

“…Objective To determine if INH-A21, an intravenous immune globulin (IGIV) derived from donors with high titers of antibody to surface adhesins of Staphylococcus…”
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Kv7 potassium channel activation with ICA‐105665 reduces photoparoxysmal EEG responses in patients with epilepsy by Kasteleijn‐Nolst Trenité, Dorotheé G. A., Biton, Victor, French, Jacqueline A., Abou‐Khalil, Bassel, Rosenfeld, William E., Diventura, Bree, Moore, Elizabeth L., Hetherington, Seth V., Rigdon, Greg C.

“…Summary Purpose To assess the effects of ICA‐105665, an agonist of neuronal Kv7 potassium channels, on epileptiform EEG discharges, evoked by intermittent…”
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Phase II, Randomized, Double-Blind, Multicenter Study Comparing the Safety and Pharmacokinetics of Tefibazumab to Placebo for Treatment of Staphylococcus aureus Bacteremia by WEEMS, J. John, STEINBERG, James P, MOORE, Thomas, PATTI, Joseph M, HETHERINGTON, Seth, TEXTER, Michele, WENZEL, Eric, KELLEY, Violet A, FOWLER, Vance G, FILLER, Scott, BADDLEY, John W, COREY, G. Ralph, SAMPATHKUMAR, Priya, WINSTON, Lisa, JOHN, Joseph F, KUBIN, Christine J, TALWANI, Rohit

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Multicenter Study To Determine Antibody Concentrations and Assess the Safety of Administration of INH-A21, a Donor-Selected Human Staphylococcal Immune Globulin, in Low-Birth-Weight Infants by CAPPARELLI, Edmund V, BLOOM, Barry T, KUESER, Tom J, OELBERG, David G, BIFANO, Ellen M, WHITE, Robert D, SCHELONKA, Robert L, PEARLMAN, Stephen A, PATTI, Joseph, HETHERINGTON, Seth V

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Phase I Dose Escalation Study To Evaluate the Safety and Pharmacokinetic Profile of Tefibazumab in Subjects with End-Stage Renal Disease Requiring Hemodialysis by HETHERINGTON, Seth, TEXTER, Michele, WENZEL, Eric, PATTI, Joseph M, REYNOLDS, Laurie, SHAMP, Trish, SWAN, Suzanne

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Open-Label, Dose Escalation Study of the Safety and Pharmacokinetic Profile of Tefibazumab in Healthy Volunteers by REILLEY, Sandra, WENZEL, Eric, REYNOLDS, Laurie, BENNETT, Beth, PATTI, Joseph M, HETHERINGTON, Seth

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Abacavir Expanded Access Program for Adult Patients Infected with Human Immunodeficiency Virus Type 1 by Kessler, Harold A., Johnson, Judy, Follansbee, Stephen, Sension, Michael G., Mildvan, Donna, Sepulveda, Gladys E., Bellos, Nicholaos C., Hetherington, Seth V.

“…Expanded access programs (EAPs) provide medication to patients with life-threatening, treatment-refractory illnesses before regulatory approval and allow the…”
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Safety and Pharmacokinetics of Abacavir (1592U89) following Oral Administration of Escalating Single Doses in Human Immunodeficiency Virus Type 1-Infected Adults by KUMAR, P. N, SWEET, D. E, MCDOWELL, J. A, SYMONDS, W, YU LOU, HETHERINGTON, S, LAFON, S

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Safety and Single-Dose Pharmacokinetics of Abacavir (1592U89) in Human Immunodeficiency Virus Type 1-Infected Children by HUGHES, W, MCDOWELL, J. A, SHENEP, J, FLYNN, P, KLINE, M. W, YOGEV, R, SYMONDS, W, YU LOU, HETHERINGTON, S

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Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial by Bernstein, David I., Wald, Anna, Warren, Terri, Fife, Kenneth, Tyring, Stephen, Lee, Patricia, Van Wagoner, Nick, Magaret, Amalia, Flechtner, Jessica B., Tasker, Sybil, Chan, Jason, Morris, Amy, Hetherington, Seth

“…Background. Genital herpes simplex virus type 2 (HSV-2) infection causes recurrent lesions and frequent viral shedding. GEN-003 is a candidate therapeutic…”
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COMMENTARY: Understanding the Benefits of Pediatric Anti-Retroviral Treatment in Resource-Limited Settings by Hetherington, Seth

“…Access to antiretroviral treatment in resource-limited settings has repeatedly demonstrated reduction in mortality. With more treatment options becoming…”
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Immune responses elicited by the GEN-003 candidate HSV-2 therapeutic vaccine in a randomized controlled dose-ranging phase 1/2a trial by Flechtner, Jessica Baker, Long, Deborah, Larson, Shane, Clemens, Veronica, Baccari, Amy, Kien, Lena, Chan, Jason, Skoberne, Mojca, Brudner, Matthew, Hetherington, Seth

“…Highlights • Cellular and humoral responses were boosted in GEN-003 vaccinated HSV-2 seropositive subjects. • Matrix-M2 adjuvant potentiated the immune…”
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Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial by Van Wagoner, Nicholas, Fife, Kenneth, Leone, Peter A, Bernstein, David I, Warren, Terri, Panther, Lori, Novak, Richard M, Beigi, Richard, Kriesel, John, Tyring, Stephen, Koltun, William, Lucksinger, Gregg, Morris, Amy, Zhang, Bin, McNeil, Lisa K, Tasker, Sybil, Hetherington, Seth, Wald, Anna

“…GEN-003 is a candidate therapeutic vaccine for genital herpes simplex virus type 2 (HSV-2). We compared virologic and clinical impact of varying GEN-003 doses…”
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Therapeutic HSV-2 vaccine decreases recurrent virus shedding and recurrent genital herpes disease by Bernstein, David I., Flechtner, Jessica B., McNeil, Lisa K., Heineman, Thomas, Oliphant, Tom, Tasker, Sybil, Wald, Anna, Hetherington, Seth

“…Genital herpes simplex virus (HSV) type 2 is a common persistent infection that frequently reactivates to cause recurrent lesions and recurrent viral shedding…”
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Recommendations from the National Vaccine Advisory Committee: Standards for Adult Immunization Practice by Orenstein, Walter A., Gellin, Bruce G., Beigi, Richard H., Despres, Sarah, LaRussa, Philip S., Lynfield, Ruth, Maldonado, Yvonne, Morita, Julie, Mouton, Charles, Pisani, Amy, Rawlins, Wayne, Rothholz, Mitchel C., Stenvig, Thomas E., Tan, Litjen (LJ), Torres, Catherine, Viswanath, Kasisomayajula, Hetherington, Seth, Hosbach, Philip, Andrus, Jon Kim, Breidbart, Scott, Daum, Robert S., Douglas, Charlene, Ehresmann, Kristen R., Etkind, Paul, Jarris, Paul, Salisbury, David, Spika, John, Temte, Jonathan L., Villaseño, Ignacio, Caserta, Vito, Church, Richard, Gruber, Marion, Mabry-Hernandez, Iris, Hill, Rick, Kelman, Jeffrey A., Martinello, Richard, Mills, Justin, Mulach, Barbara, Schuchat, Anne, Shen, Angela, Stanek, COL Scott A., Bridges, Carolyn, Orenstein, Walter A., Tan, Litjen (LJ)

“…The Advisory Committee on Immunization Practices (ACIP) recommendations for routine vaccination of adults in the US are presented. Standards for implementing…”
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Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir by Hetherington, Seth, McGuirk, Sue, Powell, Gwendolyn, Cutrell, Amy, Naderer, Odin, Spreen, Bill, Lafon, Steve, Pearce, Gill, Steel, Helen

“…Background: Hypersensitivity reactions consist of a variable group of clinical findings and have been described for a wide variety of chemical compounds…”
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The National Vaccine Advisory Committee: Reducing Patient and Provider Barriers to Maternal Immunizations: Approved by the National Vaccine Advisory Committee on June 11, 2014

“…Maternal immunization provides important health benefits for pregnant woman and their infants, and obsterical care providers are now recommended to vaccinate…”
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Fluconazole prophylaxis in preterm infants: a multicenter case-controlled analysis of efficacy and safety by Kaufman, David A, Morris, Amy, Gurka, Matt J, Kapik, Barry, Hetherington, Seth

“…ABSTRACT Background Fluconazole prophylaxis has demonstrated efficacy in single and multicenter randomized controlled trials without side effects or emergence…”
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The frequency of circulating HSV-2 antigen-specific T cells and antibodies is stable and remains unchanged by HSV-2 reactivation in infected individuals (105.54) by Skoberne, Mojca, Larson, Shane, Zielinski, Veronica, Long, Deborah, Warren, Terri, Lundberg, Amy, Hetherington, Seth, Flechtner, Jessica

“…Abstract HSV-2 infection is characterized by chronic intermittent shedding of virus and episodic clinical outbreaks. T cells and antibodies play a critical…”
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