Search Results - "HESSE, Swen"

Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia by Sabri, Osama, Meyer, Philipp M, Gräf, Susanne, Hesse, Swen, Wilke, Stephan, Becker, Georg-Alexander, Rullmann, Michael, Patt, Marianne, Luthardt, Julia, Wagenknecht, Gudrun, Hoepping, Alexander, Smits, Rene, Franke, Annegret, Sattler, Bernhard, Tiepolt, Solveig, Fischer, Steffen, Deuther-Conrad, Winnie, Hegerl, Ulrich, Barthel, Henryk, Schönknecht, Peter, Brust, Peter

“…Whether α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) expression is reduced in early Alzheimer's disease is controversial. Using (-)-[18F]Flubatine PET,…”
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Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity by Grundmann, Rico, Rullmann, Michael, Luthardt, Julia, Zientek, Franziska, Becker, Georg-Alexander, Patt, Marianne, Hankir, Mohammed K., Blüher, Matthias, Sabri, Osama, Hesse, Swen

“…The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of…”
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Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits by Dipasquale, Ottavia, Martins, Daniel, Sethi, Arjun, Veronese, Mattia, Hesse, Swen, Rullmann, Michael, Sabri, Osama, Turkheimer, Federico, Harrison, Neil A, Mehta, Mitul A, Cercignani, Mara

“…Functional magnetic resonance imaging (fMRI) can be combined with drugs to investigate the system-level functional responses in the brain to such challenges…”
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Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study by Grachev, Igor D., Meyer, Philipp M., Becker, Georg A., Bronzel, Marcus, Marsteller, Doug, Pastino, Gina, Voges, Ole, Rabinovich, Laura, Knebel, Helena, Zientek, Franziska, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gerhards, Thilo, Strauss, Maria, Kluge, Andreas, Brust, Peter, Savola, Juha-Matti, Gordon, Mark F., Geva, Michal, Hesse, Swen, Barthel, Henryk, Hayden, Michael R., Sabri, Osama

“…Purpose Pridopidine is an investigational drug for Huntington disease (HD). Pridopidine was originally thought to act as a dopamine stabilizer. However,…”
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Current radiotracers to image neurodegenerative diseases by Tiepolt, Solveig, Patt, Marianne, Aghakhanyan, Gayane, Meyer, Philipp M., Hesse, Swen, Barthel, Henryk, Sabri, Osama

“…The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure and…”
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Changes of central noradrenaline transporter availability in immunotherapy-naïve multiple sclerosis patients by Schmidt, Elisa, Schinke, Christian, Rullmann, Michael, Luthardt, Julia, Becker, Georg-Alexander, Haars, Sarah, Stoppe, Muriel, Lobsien, Donald, Hoffmann, Karl-Titus, Sabri, Osama, Hesse, Swen, Then Bergh, Florian

“…The neurotransmitter noradrenaline (NA) mediates arousal, attention and mood, and exerts anti-inflammatory and neuroprotective effects. Alterations of…”
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Increased pulmonary serotonin transporter in patients with chronic obstructive pulmonary disease who developed pulmonary hypertension by Frille, Armin, Rullmann, Michael, Becker, Georg-Alexander, Patt, Marianne, Luthardt, Julia, Tiepolt, Solveig, Wirtz, Hubert, Sabri, Osama, Hesse, Swen, Seyfarth, Hans-Juergen

“…Purpose Pulmonary hypertension (PH) is characterized by a progressive remodelling of the pulmonary vasculature resulting in right heart failure and eventually…”
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First-in-human PET quantification study of cerebral α4β2 nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F]Flubatine by Sabri, Osama, Becker, Georg-Alexander, Meyer, Philipp M., Hesse, Swen, Wilke, Stephan, Graef, Susanne, Patt, Marianne, Luthardt, Julia, Wagenknecht, Gudrun, Hoepping, Alexander, Smits, René, Franke, Annegret, Sattler, Bernhard, Habermann, Bernd, Neuhaus, Petra, Fischer, Steffen, Tiepolt, Solveig, Deuther-Conrad, Winnie, Barthel, Henryk, Schönknecht, Peter, Brust, Peter

“…α4β2* nicotinic receptors (α4β2* nAChRs) could provide a biomarker in neuropsychiatric disorders (e.g., Alzheimer's and Parkinson's diseases, depressive…”
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(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls by Tiepolt, Solveig, Becker, Georg-Alexander, Wilke, Stephan, Cecchin, Diego, Rullmann, Michael, Meyer, Philipp M., Barthel, Henryk, Hesse, Swen, Patt, Marianne, Luthardt, Julia, Wagenknecht, Gudrun, Sattler, Bernhard, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Fischer, Steffen, Gertz, Hermann-Josef, Smits, René, Hoepping, Alexander, Steinbach, Jörg, Brust, Peter, Sabri, Osama

“…Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[ 18…”
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Role of 18F-FDG-PET imaging in the diagnosis of autoimmune encephalitis by Morbelli, Silvia, Djekidel, Mehdi, Hesse, Swen, Pagani, Marco, Barthel, Henryk

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Evidence of fNIRS-Based Prefrontal Cortex Hypoactivity in Obesity and Binge-Eating Disorder by Rösch, Sarah A, Schmidt, Ricarda, Lührs, Michael, Ehlis, Ann-Christine, Hesse, Swen, Hilbert, Anja

“…Obesity (OB) and associated binge-eating disorder (BED) show increased impulsivity and emotional dysregulation. Albeit well-established in neuropsychiatric…”
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The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis by Morbelli, Silvia, Arbizu, Javier, Booij, Jan, Chen, Ming-Kai, Chetelat, Gael, Cross, Donna J., Djekidel, Mehdi, Drzezga, Alexander, Ekmekcioglu, Ozgul, Garibotto, Valentina, Hesse, Swen, Ishii, Kazunari, Saraf, Lida Jafari, Lammertsma, Adriaan A., Law, Ian, Mathews, Dana, Minoshima, Satoshi, Mosci, Karina, Pagani, Marco, Pappata, Sabina, Silverman, Daniel Hillel, Signore, Alberto, Van De Giessen, Elsmarieke, Villemagne, Victor, Barthel, Henryk

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Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [(18)F]Fluspidine-A New Tracer in Clinical Translation for Imaging of σ₁ Receptors by Kranz, Mathias, Sattler, Bernhard, Wüst, Nathanael, Deuther-Conrad, Winnie, Patt, Marianne, Meyer, Philipp M, Fischer, Steffen, Donat, Cornelius K, Wünsch, Bernhard, Hesse, Swen, Steinbach, Jörg, Brust, Peter, Sabri, Osama

“…The enantiomers of [(18)F]fluspidine, recently developed for imaging of σ₁ receptors, possess distinct pharmacokinetics facilitating their use in different…”
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Feasibility and acceptance of simultaneous amyloid PET/MRI by Schütz, Lisa, Lobsien, Donald, Fritzsch, Dominik, Tiepolt, Solveig, Werner, Peter, Schroeter, Matthias L., Berrouschot, Jörg, Saur, Dorothee, Hesse, Swen, Jochimsen, Thies, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gertz, Hermann-Josef, Villringer, Arno, Claßen, Joseph, Hoffmann, Karl-Titus, Sabri, Osama, Barthel, Henryk

“…Purpose Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative…”
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CT-based attenuation correction in I-123-ioflupane SPECT by Lange, Catharina, Seese, Anita, Schwarzenböck, Sarah, Steinhoff, Karen, Umland-Seidler, Bert, Krause, Bernd J, Brenner, Winfried, Sabri, Osama, Kurth, Jens, Hesse, Swen, Buchert, Ralph

“…Attenuation correction (AC) based on low-dose computed tomography (CT) could be more accurate in brain single-photon emission computed tomography (SPECT) than…”
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A novel thermoregulatory role for PDE10A in mouse and human adipocytes by Hankir, Mohammed K, Kranz, Mathias, Gnad, Thorsten, Weiner, Juliane, Wagner, Sally, Deuther‐Conrad, Winnie, Bronisch, Felix, Steinhoff, Karen, Luthardt, Julia, Klöting, Nora, Hesse, Swen, Seibyl, John P, Sabri, Osama, Heiker, John T, Blüher, Matthias, Pfeifer, Alexander, Brust, Peter, Fenske, Wiebke K

“…Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and is under evaluation as a drug target for several psychiatric/neurodegenerative diseases…”
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Diagnostic imaging in obesity by Machann, Jürgen, PhD, Horstmann, Annette, PhD, Born, Mark, MD, Hesse, Swen, MD, Hirsch, Franz Wolfgang, MD

“…Magnetic resonance of the body offers different techniques for mapping fat deposits (MR Imaging) and analysis of organs with small amounts of lipids (MR…”
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Noradrenaline transporter availability on [11C]MRB PET predicts weight loss success in highly obese adults by Vettermann, Franziska J., Rullmann, Michael, Becker, Georg A., Luthardt, Julia, Zientek, Franziska, Patt, Marianne, Meyer, Philipp M., McLeod, Anke, Brendel, Matthias, Blüher, Matthias, Stumvoll, Michael, Hilbert, Anja, Ding, Yu-Shin, Sabri, Osama, Hesse, Swen

“…Purpose Although the mechanisms by which the central noradrenaline (NA) system influences appetite and controls energy balance are quite well understood, its…”
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Dissociation Between Brown Adipose Tissue 18F-FDG Uptake and Thermogenesis in Uncoupling Protein 1-Deficient Mice by Hankir, Mohammed K, Kranz, Mathias, Keipert, Susanne, Weiner, Juliane, Andreasen, Sille G, Kern, Matthias, Patt, Marianne, Klöting, Nora, Heiker, John T, Brust, Peter, Hesse, Swen, Jastroch, Martin, Fenske, Wiebke K

“…18F-FDG PET imaging is routinely used to investigate brown adipose tissue (BAT) thermogenesis, which requires mitochondrial uncoupling protein 1 (UCP1). It…”
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HPA Axis Responsiveness Associates with Central Serotonin Transporter Availability in Human Obesity and Non-Obesity Controls by Schinke, Christian, Rullmann, Michael, Luthardt, Julia, Drabe, Mandy, Preller, Elisa, Becker, Georg A., Patt, Marianne, Regenthal, Ralf, Zientek, Franziska, Sabri, Osama, Then Bergh, Florian, Hesse, Swen

“…Background: Alterations of hypothalamic–pituitary–adrenal (HPA) axis activity and serotonergic signaling are implicated in the pathogenesis of human obesity…”
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