Search Results - "HESSE, Amke"

Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult by Vogler, Melanie, Zieseniss, Anke, Hesse, Amke R., Levent, Elif, Tiburcy, Malte, Heinze, Eva, Burzlaff, Nicolai, Schley, Gunnar, Eckardt, Kai Uwe, Willam, Carsten, Katschinski, Dörthe M.

“…Several genetically modified mouse models implicated that prolyl-4-hydroxylase domain (PHD) enzymes are critical mediators for protecting tissues from an…”
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In toxic demyelination oligodendroglial cell death occurs early and is FAS independent by Hesse, Amke, Wagner, Michael, Held, Jasmin, Brück, Wolfgang, Salinas-Riester, Gabriela, Hao, Zhenyue, Waisman, Ari, Kuhlmann, Tanja

“…Abstract Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS)…”
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Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury by Hölscher, Marion, Silter, Monique, Krull, Sabine, von Ahlen, Melanie, Hesse, Amke, Schwartz, Peter, Wielockx, Ben, Breier, Georg, Katschinski, Dörthe M., Zieseniss, Anke

“…Prolylhydroxylase domain proteins (PHD) are cellular oxygen-sensing molecules that regulate the stability of the α-subunit of the transcription factor hypoxia…”
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Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia by Zieseniss, Anke, Hesse, Amke R., Jatho, Aline, Krull, Sabine, Hölscher, Marion, Vogel, Sabine, Katschinski, Dörthe M.

“…Aims: The prolyl-4-hydroxylase domain (PHD) enzymes are representing novel therapeutic targets for ischemic tissue protection. Whereas the consequences of a…”
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Lights on for HIF-1α: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging by Hesse, Amke R., Levent, Elif, Zieseniss, Anke, Tiburcy, Malte, Zimmermann, Wolfram H., Katschinski, Dörthe M.

“…Background/Aims: The hypoxia inducible factor-1 (HIF-1) is a suitable marker for tissue oxygenation. We intended to develop cardiomyocytes (CMs) expressing the…”
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XIAP protects oligodendrocytes against cell death in vitro but has no functional role in toxic demyelination by Rena Hesse, Amke, Hagemeier, Karin, Lürbke, Alexander, Held, Jasmin, Friedman, Hana, Peterson, Alan, Brück, Wolfgang, Kuhlmann, Tanja

“…Oligodendroglial damage and loss are typical characteristics of demyelinating diseases such as multiple sclerosis (MS) and the leukodystrophies. Axonal loss is…”
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Unfavourable consequences of chronic cardiac HIF-1α stabilization by HÖLSCHER, Marion, SCHÄFER, Katrin, MAIER, Lars S, KATSCHINSKI, Dörthe M, ZIESENISS, Anke, KRULL, Sabine, FARHAT, Katja, HESSE, Amke, SITTER, Monique, YUN LIN, PICHLER, Bernd J, THISTLETHWAITE, Patricia, EL-ARMOUCHE, Ali

“…The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene expression. The effects of chronically stabilized cardiac HIF-1α and its role in…”
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Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-[beta]1 processing by Wottawa, Marieke, Leisering, Pia, Ahlen, Melanie von, Schnelle, Moritz, Vogel, Sabine, Malz, Cordula, Bordoli, Mattia Renato, Camenisch, Gieri, Hesse, Amke, Napp, Joanna, Alves, Frauke, Kristiansen, Glen, Farhat, Katja, Katschinski, Dörthe Magdalena

“…The prolyl-4-hydroxylase domain 1-3 (PHD1-3) enzymes are regulating the protein stability of the [alpha]-subunit of the hypoxia-inducible factor-1 (HIF-1),…”
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Knockdown of prolyl‐4‐hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA‐MB‐231 cells by affecting TGF‐β1 processing by Wottawa, Marieke, Leisering, Pia, Ahlen, Melanie von, Schnelle, Moritz, Vogel, Sabine, Malz, Cordula, Bordoli, Mattia Renato, Camenisch, Gieri, Hesse, Amke, Napp, Joanna, Alves, Frauke, Kristiansen, Glen, Farhat, Katja, Katschinski, Dörthe Magdalena

“…The prolyl‐4‐hydroxylase domain 1–3 (PHD1–3) enzymes are regulating the protein stability of the α‐subunit of the hypoxia‐inducible factor‐1 (HIF‐1), which…”
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Reduced Treg frequency in LFA‐1‐deficient mice allows enhanced T effector differentiation and pathology in EAE by Gültner, Sandra, Kuhlmann, Tanja, Hesse, Amke, Weber, Jan P, Riemer, Constanze, Baier, Michael, Hutloff, Andreas

“…The αLβ2‐integrin LFA‐1 (CD11a/CD18) is known as an important molecule for leukocyte migration. However, the precise role of LFA‐1 in the pathogenesis of EAE…”
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Lights on for HIF-1a: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging by Hesse, Amke R., Levent, Elif, Zieseniss, Anke, Tiburcy, Malte, Zimmermann, Wolfram H., Katschinski, Dörthe M.

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