Search Results - "HESS, S. D"
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1
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo
Published in The Journal of pharmacology and experimental therapeutics (01-06-1999)“…Group III metabotropic glutamate receptors (mGluRs) are thought to modulate neurotoxicity of excitatory amino acids, via mechanisms of presynaptic inhibition,…”
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2
A Functional Role for GTP-Binding Proteins in Synaptic Vesicle Cycling
Published in Science (American Association for the Advancement of Science) (19-02-1993)“…The squid giant synapse was used to test the hypothesis that guanosine-5′-triphosphate (GTP)-binding proteins regulate the local distribution of synaptic…”
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3
Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors
Published in The Journal of pharmacology and experimental therapeutics (01-08-1996)“…Human cDNAs encoding N-methyl-D-aspartate receptor type (NMDAR)1A, NMDAR2A and NMDAR2B subunits were cloned and receptors encoded by these cDNAs were…”
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4
Comparison of human lung cancer/SCID mouse tumor xenografts and cell culture growth with patient clinical outcomes
Published in Journal of cancer research and clinical oncology (01-10-2003)“…Leukemic cell growth in SCID mice has been reported as a predictor of disease relapse. However, there is a paucity of literature regarding xenograft growth and…”
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5
Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells
Published in The Journal of pharmacology and experimental therapeutics (01-10-1996)“…The electrophysiological and pharmacological properties of two mammalian cell lines stably transfected with cDNAs encoding recombinant human…”
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6
Biliopancreatic diversion with a duodenal switch
Published in Obesity surgery (01-06-1998)“…This paper evaluates biliopancreatic diversion combined with the duodenal switch, forming a hybrid procedure which is a combination of restriction and…”
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7
Calcium oscillations in human T and natural killer cells depend upon membrane potential and calcium influx
Published in The Journal of immunology (1950) (01-04-1993)“…With the use of single-cell digital imaging of the fluorescent Ca2+ indicator dye fura-2 we investigated Ca2+ signaling in human T lymphocytes and NK cells…”
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8
Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5
Published in Neuropharmacology (01-08-1995)“…We have isolated and characterized overlapping cDNAs that encode two isoforms of the human metabotropic glutamate receptor subtype 5 (hmGluR5). The deduced…”
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9
The Human N‐Methyl‐d‐Aspartate Receptor 2C Subunit: Genomic Analysis, Distribution in Human Brain, and Functional Expression
Published in Journal of neurochemistry (01-11-1998)“…: cDNAs encoding four isoforms of the human NMDA receptor (NMDAR) NMDAR2C (hNR2C‐1, ‐2, ‐3, and ‐4) have been isolated and characterized. The overall identity…”
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10
Pharmacological characterization of the human ionotropic glutamate receptor subtype GluR3 stably expressed in mammalian cells
Published in The Journal of pharmacology and experimental therapeutics (01-04-1998)“…We have cloned the human ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR3 flip splice variant (hGluR3i) and developed…”
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11
Functional Characterization of Human N‐Methyl‐d‐Aspartate Subtype 1A/2D Receptors
Published in Journal of neurochemistry (01-03-1998)“…: The human NMDAR2D subunit was cloned, and the pharmacological properties of receptors resulting from injection of transcripts encoding human NMDAR1A and…”
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12
Cytokines delivered by biodegradable microspheres promote effective suppression of human tumors by human peripheral blood lymphocytes in the SCID-winn model
Published in Journal of immunotherapy (1997) (01-03-2000)“…A new technology for the local and sustained delivery of immunostimulatory molecules to the tumor environment for cancer immunotherapy was evaluated. The…”
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13
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
Published in The Journal of pharmacology and experimental therapeutics (01-07-1999)“…Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an automated high-throughput…”
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14
Human–SCID mouse chimeric models for the evaluation of anti-cancer therapies
Published in Trends in Immunology (01-07-2001)“…The ability to engraft human tumors and human immunocompetent cells successfully in severe combined immunodeficient (SCID) mice has spawned the development and…”
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15
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Published in Neuropharmacology (01-10-1999)“…In the present paper we describe 2-methyl-6-(phenylethynyl)-pyridine (MPEP) as a potent, selective and systemically active antagonist for the metabotropic…”
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16
Sudden death after catheter-induced atrioventricular junctional ablation
Published in Chest (01-12-1985)“…Atrioventricular (AV) junctional ablation was performed in a 59-year-old woman with recurrent atrial fibrillation refractory to treatment with digoxin,…”
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17
Transmural Distribution of Myocardial Blood Flow during Systole in the Awake Dog
Published in Circulation research (01-01-1976)“…This study was designed to quantitate transmural myocardial blood flow when coronary arterial inflow was limited to systole and during the subsequent reactive…”
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18
Reactive hyperemia following one-beat coronary occlusions in the awake dog
Published in The American journal of physiology (01-03-1986)“…This study was performed to examine the effect of alterations of cardiac activity during brief coronary artery occlusions on the subsequent reactive hyperemic…”
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19
CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice
Published in Cancer Immunology, Immunotherapy (01-10-2005)“…Previous studies by others using transplantable murine tumor models have demonstrated that the administration of antibodies that block CTLA-4 interaction with…”
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20
Electrophysiologic testing in the evaluation of patients with syncope of undetermined origin
Published in The American journal of cardiology (01-01-1982)“…Thirty-two patients were prospectively evaluated for syncope (recurrent in 26 patients) with conventional neurologic and cardiovascular testing without…”
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