Search Results - "HESS, J. Fred"

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice by Hastings, Nicholas B, Wang, Xiaohai, Song, Lixin, Butts, Brent D, Grotz, Diane, Hargreaves, Richard, Fred Hess, J, Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X, Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J, Ouyang, Xuesong, Rosahl, Thomas W, Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J, Wang, Ganfeng, Duffy, Joseph L, Parker, Eric M, Zhang, Lili

“…Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative…”
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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies by Selnick, Harold G, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B, Ballard, Jeanine E, Marcus, Jacob, Klein, Daniel J, Wang, Xiaohai, Pearson, Michelle, Savage, Mary J, Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J, Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L, McEachern, Ernest J

“…Inhibition of O-GlcNAcase (OGA) has emerged as a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such as Alzheimer’s…”
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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy by Wang, Xiaohai, Smith, Karen, Pearson, Michelle, Hughes, Anna, Cosden, Mali L, Marcus, Jacob, Hess, J Fred, Savage, Mary J, Rosahl, Thomas, Smith, Sean M, Schachter, Joel B, Uslaner, Jason M

“…Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been…”
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Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology by Song, Lixin, Lu, Sherry X, Ouyang, Xuesong, Melchor, Jerry, Lee, Julie, Terracina, Giuseppe, Wang, Xiaohai, Hyde, Lynn, Hess, J Fred, Parker, Eric M, Zhang, Lili

“…Microtubule associated protein tau is the major component of the neurofibrillary tangles (NFTs) found in the brains of patients with Alzheimer's disease and…”
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Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6 by Holmen, Sheri L, Giambernardi, Troy A, Zylstra, Cassandra R, Buckner‐Berghuis, Bree D, Resau, James H, Hess, J Fred, Glatt, Vaida, Bouxsein, Mary L, Ai, Minrong, Warman, Matthew L, Williams, Bart O

“…Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact genetically to control bone or skeletal development, we created mice…”
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Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment by Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., Wang, Ruiping, DiLella, Anthony G., Hess, J. Fred, Kinney, Gene G., Conn, P. Jeffrey

“…Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in North America. Current treatments focused on…”
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Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors by Parmentier‐Batteur, Sophie, Finger, Eleftheria N., Krishnan, Raghu, Rajapakse, Hemaka A., Sanders, John M., Kandpal, Geeta, Zhu, Hong, Moore, Keith P., Regan, Christopher P., Sharma, Sujata, Hess, J. Fred, Williams, Theresa M., Reynolds, Ian J., Vacca, Joseph P., Mark, Robert J., Nantermet, Philippe G.

“…J. Neurochem. (2011) 118, 1016–1031. The EphA4 receptor and its ephrin ligands are involved in astrocytic gliosis following CNS injury. Therefore, a strategy…”
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Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation by Ma, Lei, Cao, Tracy T., Kandpal, Geeta, Warren, Lee, Fred Hess, J., Seabrook, Guy R., Ray, William J.

“…In Parkinson’s disease substantia nigra neurons degenerate likely due to oxidative damage interacting with genetic risk factors. Here, SH-SY5Y cells expressing…”
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Disruption of the Keap1-containing ubiquitination complex as an antioxidant therapy by Kern, Jonathan T, Hannink, Mark, Hess, J Fred

“…The transcription of antioxidant response element (ARE)-containing cytoprotective genes has been proposed as a means to combat oxidative stress-related…”
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MK-8719, a Novel and Selective O -GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy by Wang, Xiaohai, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.

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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs) by Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J

“…Neurofibrillary tangles (NFTs) made up of aggregated tau protein have been identified as the pathologic hallmark of several neurodegenerative diseases…”
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The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin by Pettibone, Douglas J, Hess, J Fred, Hey, Patricia J, Jacobson, Marlene A, Leviten, Michael, Lis, Edward V, Mallorga, Pierre J, Pascarella, Danette M, Snyder, Melissa A, Williams, Jacinta B, Zeng, Zhizhen

“…Mice deficient in the neurotensin (NT)-1 receptor (NTR1) were developed to characterize the NT receptor subtypes that mediate various in vivo responses to NT…”
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The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137 by Lyons, Paul A, Hancock, Wayne W, Denny, Paul, Lord, Christopher J, Hill, Natasha J, Armitage, Nicola, Siegmund, Thorsten, Todd, John A, Phillips, Michael S, Hess, J Fred, Chen, Shiow-Ling, Fischer, Paul A, Peterson, Laurence B, Wicker, Linda S

“…Previous analyses of NOD mice have shown that some genes control the development of both insulitis and diabetes, while other loci influence diabetes without…”
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Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist by Su, Dai-Shi, Markowitz, M. Kristine, DiPardo, Robert M, Murphy, Kathy L, Harrell, C. Meacham, O'Malley, Stacy S, Ransom, Richard W, Chang, Raymond S. L, Ha, Sookhee, Hess, Fred J, Pettibone, Douglas J, Mason, Glenn S, Boyce, Susan, Freidinger, Roger M, Bock, Mark G

“…Bradykinin (BK) plays an important role in the pathophysiological processes accompanying pain and inflammation. Selective bradykinin B1 receptor antagonists…”
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Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene by Twells, Rebecca C J, Mein, Charles A, Phillips, Michael S, Hess, J Fred, Veijola, Riitta, Gilbey, Matthew, Bright, Matthew, Metzker, Michael, Lie, Benedicte A, Kingsnorth, Amanda, Gregory, Edward, Nakagawa, Yusuke, Snook, Hywel, Wang, William Y S, Masters, Jennifer, Johnson, Gillian, Eaves, Iain, Howson, Joanna M M, Clayton, David, Cordell, Heather J, Nutland, Sarah, Rance, Helen, Carr, Philippa, Todd, John A

“…Patterns of linkage disequilibrium (LD) in the human genome are beginning to be characterized, with a paucity of haplotype diversity in "LD blocks,"…”
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Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model by Hess, J Fred, Ransom, Richard W, Zeng, Zhizhen, Chang, Raymond S L, Hey, Patricia J, Warren, Lee, Harrell, Charles M, Murphy, Kathryn L, Chen, Tsing-Bau, Miller, Patricia J, Lis, Edward, Reiss, Duane, Gibson, Raymond E, Markowitz, M Kristine, DiPardo, Robert M, Su, Dai-Shi, Bock, Mark G, Gould, Robert J, Pettibone, Douglas J

“…Antagonists of the B1 bradykinin receptor (B1R) offer the promise of novel therapeutic agents for the treatment of inflammatory and neuropathic pain. However,…”
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Conserved Aspartate Residues and Phosphorylation in Signal Transduction by the Chemotaxis Protein CheY by Bourret, Robert B., Hess, J. Fred, Simon, Melvin I.

“…The CheY protein is phosphorylated by CheA and dephosphorylated by CheZ as part of the chemotactic signal transduction pathway in Escherichia coli…”
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Leptin receptor missense mutation in the fatty Zucker rat by Phillips, Michael S, Liu, Qingyun, Hammond, Holly A, Dugan, Valarie, Hey, Patricia J, Caskey, C. Thomas, Hess, J. Fred

“…The discovery of leptin, a peptide hormone synthesized in adipocytes, has led to the identification of a novel signal transduction pathway involved in the…”
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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists by Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wai, Jenny M. C., DiPardo, Robert M., Murphy, Kathy L., Ransom, Richard W., Harrell, C. Meacham, Reiss, Duane R., Holahan, Marie A., Cook, Jacquelynn, Hess, J. Fred, Sain, Nova, Urban, Mark O., Tang, Cuyue, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.

“…A series of biphenylaminocyclopropane carboxamide based bradykinin B1 receptor antagonists has been developed that possesses good pharmacokinetic properties…”
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Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage by Cao, Tracy T., Ma, Lei, Kandpal, Geeta, Warren, Lee, Hess, J. Fred, Seabrook, Guy R.

“…The ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating potentially damaging…”
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