Remodeling of the human dermis after application of salicylate silanol

Remodeling of the human dermis after application of salicylate silanol

Recently, a controlled double-blind study in patients with photo-aged facial skin demonstrated the beneficial role of oral intake of silanol for skin, hair and nails. The aim of our pilot study was to investigate histologic alterations in human skin after injection of silanol. Seven healthy female c...

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Bibliographic Details
Published in:Archives of Dermatological Research Vol. 299; no. 1; pp. 41 - 45
Main Authors: HERREROS, F. O. C, CINTRA, M. L, ADAM, R. L, DE MORAES, A. Machado, METZE, Konradin
Format: Journal Article
Language:English
Published: Berlin Springer 01-04-2007
Springer Nature B.V
Subjects:
Adult
Biological and medical sciences
Biopsy
Collagen - drug effects
Collagen - metabolism
Dermatology
Dermis - drug effects
Dermis - metabolism
Dermis - pathology
Dose-Response Relationship, Drug
Elastic Tissue - drug effects
Elastic Tissue - metabolism
Female
Humans
Medical sciences
Middle Aged
Pilot Projects
Salicylates - pharmacology
Skin Aging - drug effects
Skin Physiological Phenomena
Human
Texture analysis
Fast Fourier transformation
Dermatology
Dermis
Fast Fourier Transform
Fractals
Remodeling
Silanol
Collagen
Elastic fiber
Salicylates
Derm
Application
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Summary:Recently, a controlled double-blind study in patients with photo-aged facial skin demonstrated the beneficial role of oral intake of silanol for skin, hair and nails. The aim of our pilot study was to investigate histologic alterations in human skin after injection of silanol. Seven healthy female caucasian volunteers with a moderate degree of photoaged skin received ten sessions of weekly injections of 0.1% salicylate silanol in the left ventral lateral forearm. The histologic features of punch biopsies of the treated area and the nontreated contralateral arm were compared and the collagen and elastic fibers quantified. Texture analysis was performed on digitalized microscopic images by analyzing the Sarkar fractal dimension or amplitudes (inertia values) after Fast Fourier transformation. The treated area revealed a statistically significant increase of the density of both collagen and elastic fibers. Texture analysis showed more compact and homogeneously distributed collagen fibers after silicon injection. Our results suggest that the application of silicon may stimulate the production of collagen and elastic fibers leading to remodeling of the dermal fiber architecture, which may explain the improvement of the skin surface observed in clinical studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-007-0739-8