Search Results - "HEROLD, KEVAN C."

Immunotherapy: Building a bridge to a cure for type 1 diabetes by Bluestone, Jeffrey A, Buckner, Jane H, Herold, Kevan C

“…Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the insulin-producing β cells in the pancreatic islets. Genetic and…”
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Quantifying the effect of experimental perturbations at single-cell resolution by Burkhardt, Daniel B., Stanley, Jay S., Tong, Alexander, Perdigoto, Ana Luisa, Gigante, Scott A., Herold, Kevan C., Wolf, Guy, Giraldez, Antonio J., van Dijk, David, Krishnaswamy, Smita

“…Current methods for comparing single-cell RNA sequencing datasets collected in multiple conditions focus on discrete regions of the transcriptional state…”
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Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association by Insel, Richard A, Dunne, Jessica L, Atkinson, Mark A, Chiang, Jane L, Dabelea, Dana, Gottlieb, Peter A, Greenbaum, Carla J, Herold, Kevan C, Krischer, Jeffrey P, Lernmark, Åke, Ratner, Robert E, Rewers, Marian J, Schatz, Desmond A, Skyler, Jay S, Sosenko, Jay M, Ziegler, Anette-G

“…Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum that…”
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Thinking bedside at the bench: the NOD mouse model of T1DM by Reed, James C., Herold, Kevan C.

“…Successful studies in the nonobese diabetic (NOD) mouse model often do not translate to positive outcomes in human studies. This Perspectives outlines the…”
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Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes by Wright, Jordan J, Salem, Joe-Elie, Johnson, Douglas B, Lebrun-Vignes, Bénédicte, Stamatouli, Angeliki, Thomas, James W, Herold, Kevan C, Moslehi, Javid, Powers, Alvin C

“…Wright et al. discuss the increased reporting of immune checkpoint inhibitor (CPI)-associated diabetes. They analyzed VigiBase, the World Health Organization's…”
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Control of TH17 cells occurs in the small intestine by Esplugues, Enric, Huber, Samuel, Gagliani, Nicola, Hauser, Anja E., Town, Terrence, Wan, Yisong Y., O’Connor, William, Rongvaux, Anthony, Van Rooijen, Nico, Haberman, Ann M., Iwakura, Yoichiro, Kuchroo, Vijay K., Kolls, Jay K., Bluestone, Jeffrey A., Herold, Kevan C., Flavell, Richard A.

“…Keeping T H 17 cells under wraps Interleukin-17-producing T helper (T H 17) cells serve an important role in the immune system, but are strongly implicated in…”
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Natural mucosal barriers and COVID-19 in children by Pierce, Carl A, Sy, Sharlene, Galen, Benjamin, Goldstein, Doctor Y, Orner, Erika, Keller, Marla J, Herold, Kevan C, Herold, Betsy C

“…BACKGROUNDCoronavirus disease 2019 (COVID-19) is more benign in children compared with adults for unknown reasons. This contrasts with other respiratory…”
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Detection of β cell death in diabetes using differentially methylated circulating DNA by Akirav, Eitan M, Lebastchi, Jasmin, Galvan, Eva M, Henegariu, Octavian, Akirav, Michael, Ablamunits, Vitaly, Lizardi, Paul M, Herold, Kevan C

“…In diabetes mellitus, β cell destruction is largely silent and can be detected only after significant loss of insulin secretion capacity. We have developed a…”
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Checkpoint inhibitor-induced insulin-dependent diabetes: an emerging syndrome by Perdigoto, Ana Luisa, Quandt, Zoe, Anderson, Mark, Herold, Kevan C

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Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial by Sherry, Nicole, Dr, Hagopian, William, MD, Ludvigsson, Johnny, Prof, Jain, Sunil M, MD, Wahlen, Jack, MD, Ferry, Robert J, Prof, Bode, Bruce, MD, Aronoff, Stephen, MD, Holland, Christopher, MS, Carlin, David, PhD, King, Karen L, MS, Wilder, Ronald L, MD, Pillemer, Stanley, MD, Bonvini, Ezio, MD, Johnson, Syd, PhD, Stein, Kathryn E, PhD, Koenig, Scott, MD, Herold, Kevan C, Prof, Daifotis, Anastasia G, MD

“…Summary Background Findings of small studies have suggested that short treatments with anti-CD3 monoclonal antibodies that are mutated to reduce Fc receptor…”
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Citrullination of glucokinase is linked to autoimmune diabetes by Yang, Mei-Ling, Horstman, Sheryl, Gee, Renelle, Guyer, Perrin, Lam, TuKiet T., Kanyo, Jean, Perdigoto, Ana L., Speake, Cate, Greenbaum, Carla J., Callebaut, Aïsha, Overbergh, Lut, Kibbey, Richard G., Herold, Kevan C., James, Eddie A., Mamula, Mark J.

“…Inflammation, including reactive oxygen species and inflammatory cytokines in tissues amplify various post-translational modifications of self-proteins. A…”
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Immune Checkpoint Inhibitor-Induced Hypophysitis and Patterns of Loss of Pituitary Function by Jessel, Shlomit, Weiss, Sarah A, Austin, Matthew, Mahajan, Amit, Etts, Katrina, Zhang, Lin, Aizenbud, Lilach, Perdigoto, Ana Luisa, Hurwitz, Michael, Sznol, Mario, Herold, Kevan C, Kluger, Harriet M

“…Immune checkpoint inhibitors (ICI) are clinically active across multiple tumor types but the associated immune-related adverse events (irAEs) lead to treatment…”
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Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells by Tornovsky-Babeay, Sharona, Dadon, Daniela, Ziv, Oren, Tzipilevich, Elhanan, Kadosh, Tehila, Schyr-Ben Haroush, Rachel, Hija, Ayat, Stolovich-Rain, Miri, Furth-Lavi, Judith, Granot, Zvi, Porat, Shay, Philipson, Louis H., Herold, Kevan C., Bhatti, Tricia R., Stanley, Charles, Ashcroft, Frances M., In’t Veld, Peter, Saada, Ann, Magnuson, Mark A., Glaser, Benjamin, Dor, Yuval

“…β cell failure in type 2 diabetes (T2D) is associated with hyperglycemia, but the mechanisms are not fully understood. Congenital hyperinsulinism caused by…”
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Inducing and Administering Tregs to Treat Human Disease by Perdigoto, Ana Luisa, Chatenoud, Lucienne, Bluestone, Jeffrey A, Herold, Kevan C

“…Regulatory T cells (Tregs) control unwanted immune responses, including those that mediate tolerance to self as well as to foreign antigens. Their mechanisms…”
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The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling by Reed, James C, Preston-Hurlburt, Paula, Philbrick, William, Betancur, Gabriel, Korah, Maria, Lucas, Carrie, Herold, Kevan C

“…The receptor for advanced glycation endproducts (RAGE) is expressed in T cells after activation with antigen and is constitutively expressed in T cells from…”
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Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes by Rui, Jinxiu, Deng, Songyan, Perdigoto, Ana Luisa, Ponath, Gerald, Kursawe, Romy, Lawlor, Nathan, Sumida, Tomokazu, Levine-Ritterman, Maya, Stitzel, Michael L., Pitt, David, Lu, Jun, Herold, Kevan C.

“…β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune…”
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Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial by Wherrett, Diane K, MD, Bundy, Brian, PhD, Becker, Dorothy J, Prof, DiMeglio, Linda A, MD, Gitelman, Stephen E, Prof, Goland, Robin, Prof, Gottlieb, Peter A, Prof, Greenbaum, Carla J, MD, Herold, Kevan C, Prof, Marks, Jennifer B, Prof, Monzavi, Roshanak, MD, Moran, Antoinette, Prof, Orban, Tihamer, MD, Palmer, Jerry P, MD, Raskin, Philip, Prof, Rodriguez, Henry, Prof, Schatz, Desmond, Prof, Wilson, Darrell M, Prof, Krischer, Jeffrey P, Prof, Skyler, Jay S, Dr, Prof

“…Summary Background Glutamic acid decarboxylase (GAD) is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. In animal models of…”
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Phenotypes Associated With Zones Defined by Area Under the Curve Glucose and C-peptide in a Population With Islet Autoantibodies by Sosenko, Jay M, Cuthbertson, David, Sims, Emily K, Ismail, Heba M, Nathan, Brandon M, Jacobsen, Laura M, Atkinson, Mark A, Evans-Molina, Carmella, Herold, Kevan C, Skyler, Jay S, Redondo, Maria J

“…Metabolic zones were developed to characterize heterogeneity of individuals with islet autoantibodies. Baseline 2-h oral glucose tolerance test data from 6,620…”
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HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal by Pierce, Carl A, Loh, Lip Nam, Steach, Holly R, Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C, Herold, Betsy C

“…Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well…”
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A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes by HEROLD, Kevan C, GITELMAN, Stephen E, MASHARANI, Umesh, HAGOPIAN, William, BISIKIRSKA, Brygida, DONALDSON, David, ROTHER, Kristina, DIAMOND, Beverly, HARLAN, David M, BLUESTONE, Jeffrey A

“…A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years…”
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