Search Results - "HEROLD, BETSY C."

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry by Cheshenko, Natalia, Pierce, Carl, Herold, Betsy C

“…Herpes simplex virus (HSV) entry is associated with Akt translocation to the outer leaflet of the plasma membrane to promote a complex signaling cascade. We…”
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Natural mucosal barriers and COVID-19 in children by Pierce, Carl A, Sy, Sharlene, Galen, Benjamin, Goldstein, Doctor Y, Orner, Erika, Keller, Marla J, Herold, Kevan C, Herold, Betsy C

“…BACKGROUNDCoronavirus disease 2019 (COVID-19) is more benign in children compared with adults for unknown reasons. This contrasts with other respiratory…”
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A non-neutralizing glycoprotein B monoclonal antibody protects against herpes simplex virus disease in mice by Kuraoka, Masayuki, Aschner, Clare Burn, Windsor, Ian W, Mahant, Aakash Mahant, Garforth, Scott J, Kong, Susan Luozheng, Achkar, Jacqueline M, Almo, Steven C, Kelsoe, Garnett, Herold, Betsy C

“…There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb…”
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Lactobacillus crispatus dominant vaginal microbiome is associated with inhibitory activity of female genital tract secretions against Escherichia coli by Ghartey, Jeny P, Smith, Benjamin C, Chen, Zigui, Buckley, Niall, Lo, Yungtai, Ratner, Adam J, Herold, Betsy C, Burk, Robert D

“…Female genital tract secretions inhibit E. coli ex vivo and the activity may prevent colonization and provide a biomarker of a healthy microbiome. We…”
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Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread by Nixon, Briana, Stefanidou, Martha, Mesquita, Pedro M M, Fakioglu, Esra, Segarra, Theodore, Rohan, Lisa, Halford, William, Palmer, Kenneth E, Herold, Betsy C

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Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women by Thurman, Andrea Ries, Schwartz, Jill L, Brache, Vivian, Clark, Meredith R, McCormick, Timothy, Chandra, Neelima, Marzinke, Mark A, Stanczyk, Frank Z, Dezzutti, Charlene S, Hillier, Sharon L, Herold, Betsy C, Fichorova, Raina, Asin, Susana N, Rollenhagen, Christiane, Weiner, Debra, Kiser, Patrick, Doncel, Gustavo F

“…To prevent the global health burdens of human immunodeficiency virus [HIV] and unintended/mistimed pregnancies, we developed an intravaginal ring [IVR] that…”
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HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal by Pierce, Carl A, Loh, Lip Nam, Steach, Holly R, Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C, Herold, Betsy C

“…Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well…”
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Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease by Petro, Christopher, González, Pablo A, Cheshenko, Natalia, Jandl, Thomas, Khajoueinejad, Nazanin, Bénard, Angèle, Sengupta, Mayami, Herold, Betsy C, Jacobs, William R

“…Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of…”
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Novel Mouse Model of Recurrent Sublethal Herpes Simplex Virus Infection Recapitulates Human Antibody Responses to Primary and Chronic Infection by Mahant, Aakash Mahant, Gualdron, Tania Jaimes, Herold, Betsy C

“…Herpes simplex virus (HSV) vaccine development has been impeded by the absence of predictive preclinical models and defined correlates of immune protection…”
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Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges by Smith, James M., Rastogi, Rachna, Teller, Ryan S., Srinivasan, Priya, Mesquita, Pedro M. M., Nagaraja, Umadevi, McNicholl, Janet M., Hendry, R. Michael, Dinh, Chuong T., Martina, Amy, Herold, Betsy C., Kiser, Patrick F.

“…Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse…”
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Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study by Thurman, Andrea R, Brache, Vivian, Cochon, Leila, Ouattara, Louise A, Chandra, Neelima, Jacot, Terry, Yousefieh, Nazita, Clark, Meredith R, Peet, Melissa, Hanif, Homaira, Schwartz, Jill L, Ju, Susan, Marzinke, Mark A, Erikson, David W, Parikh, Urvi, Herold, Betsy C, Fichorova, Raina N, Tolley, Elizabeth, Doncel, Gustavo F

“…Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women. In this…”
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Impact of reproductive aging on the vaginal microbiome and soluble immune mediators in women living with and at-risk for HIV infection by Murphy, Kerry, Keller, Marla J, Anastos, Kathryn, Sinclair, Shada, Devlin, J Cooper, Shi, Qiuhu, Hoover, Donald R, Starkman, Brian, McGillick, Jamie, Mullis, Caroline, Minkoff, Howard, Dominguez-Bello, Maria Gloria, Herold, Betsy C

“…Reproductive aging may impact the vaginal microbiome and genital tract mucosal immune environment and contribute to genital tract health in women living with…”
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Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk by Irvin, Susan C, Herold, Betsy C

“…Epidemiological studies suggest that medroxyprogesterone acetate (MPA) may increase the risk of HIV-1. The current studies were designed to identify potential…”
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Herpes Simplex Virus 2 (HSV-2) Prevents Dendritic Cell Maturation, Induces Apoptosis, and Triggers Release of Proinflammatory Cytokines: Potential Links to HSV-HIV Synergy by Stefanidou, Martha, Ramos, Irene, Mas Casullo, Veronica, Trépanier, Janie B, Rosenbaum, Sara, Fernandez-Sesma, Ana, Herold, Betsy C

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Antibodies Elicited in Response to a Single Cycle Glycoprotein D Deletion Viral Vaccine Candidate Bind C1q and Activate Complement Mediated Neutralization and Cytolysis by Visciano, Maria Luisa, Mahant, Aakash Mahant, Pierce, Carl, Hunte, Richard, Herold, Betsy C

“…Herpes simplex virus (HSV) prevention is a global health priority but, despite decades of research, there is no effective vaccine. Prior efforts focused on…”
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Very low incidence of Clostridioides difficile infection in pediatric sickle cell disease patients by Lee, Philip, Sinha, Arpan A, Soma, Vijaya L, Cruz, Carlos, Wang, Tao, Aroniadis, Olga, Herold, Betsy C, Frenette, Paul S, Goldman, David L, Manwani, Deepa

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An innate antiviral pathway acting before interferons at epithelial surfaces by Iversen, Marie B, Reinert, Line S, Thomsen, Martin K, Bagdonaite, Ieva, Nandakumar, Ramya, Cheshenko, Natalia, Prabakaran, Thaneas, Vakhrushev, Sergey Y, Krzyzowska, Malgosha, Kratholm, Sine K, Ruiz-Perez, Fernando, Petersen, Steen V, Goriely, Stanislas, Bibby, Bo Martin, Eriksson, Kristina, Ruland, Jürgen, Thomsen, Allan R, Herold, Betsy C, Wandall, Hans H, Frische, Sebastian, Holm, Christian K, Paludan, Søren R

“…Mucosal surfaces often represent the first point of entry for pathogens. Paludan and colleagues demonstrate that disruption of the mucus itself can initiate a…”
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Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety by Mesquita, Pedro M. M., Cheshenko, Natalia, Wilson, Sarah S., Mhatre, Mohak, Guzman, Esmeralda, Fakioglu, Esra, Keller, Marla J., Herold, Betsy C.

“…BackgroundThe lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were designed to…”
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Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis by Taneva, Ekaterina, Crooker, Kerry, Park, Sung Hyun, Su, Jonathan T, Ott, Adina, Cheshenko, Natalia, Szleifer, Igal, Kiser, Patrick F, Frank, Bruce, Mesquita, Pedro M M, Herold, Betsy C

“…Intravaginal rings releasing tenofovir (TFV) or its prodrug, tenofovir disoproxil fumarate (TDF), are being evaluated for HIV and herpes simplex virus (HSV)…”
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Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy by Nabi, Rafiq, Moldoveanu, Zina, Wei, Qing, Golub, Elizabeth T, Durkin, Helen G, Greenblatt, Ruth M, Herold, Betsy C, Nowicki, Marek J, Kassaye, Seble, Cho, Michael W, Pinter, Abraham, Landay, Alan L, Mestecky, Jiri, Kozlowski, Pamela A

“…Mechanisms responsible for natural control of human immunodeficiency type 1 (HIV) replication in elite controllers (EC) remain incompletely defined. To…”
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