Search Results - "HERMOSO, Juan"

Grid Voltage Synchronization for Distributed Generation Systems Under Grid Fault Conditions by Luna, Alvaro, Rocabert, Joan, Candela, J. Ignacio, Hermoso, Juan Ramon, Teodorescu, Remus, Blaabjerg, Frede, Rodriguez, Pedro

“…The actual grid code requirements for the grid connection of distributed generation systems, mainly wind and photovoltaic (PV) systems, are becoming very…”
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Penicillin‐binding protein 2a of methicillin‐resistant Staphylococcus aureus by Fishovitz, Jennifer, Hermoso, Juan A., Chang, Mayland, Mobashery, Shahriar

“…High‐level resistance to β‐lactam antibiotics in methicillin‐resistant Staphylococcus aureus (MRSA) is due to expression of penicillin‐binding protein 2a…”
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Teaching an old dog new tricks: repurposing β-lactams by Miguel-Ruano, Vega, Hermoso, Juan A.

“…Recently, Martelli and colleagues reported on the structural and functional characterization of new antimycobacterials based on N-thio-β-lactams. Surprisingly,…”
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Unconventional Antibacterials and Adjuvants by Chang, Mayland, Mahasenan, Kiran V, Hermoso, Juan A, Mobashery, Shahriar

“…Conspectus The need for new classes of antibacterials is genuine in light of the dearth of clinical options for the treatment of bacterial infections. The…”
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Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases by Alcorlo, Martín, Martínez-Caballero, Siseth, Molina, Rafael, Hermoso, Juan A

“…[Display omitted] •Recent results on the structural biology of PG hydrolases reviewed.•Structural features of PG recognition and regulation in amidases and LTs…”
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Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis by Li, Jianwei, Xu, Xin, Shi, Jian, Hermoso, Juan A., Sham, Lok-To, Luo, Min

“…The FtsEX complex regulates, directly or via a protein mediator depending on bacterial genera, peptidoglycan degradation for cell division. In mycobacteria and…”
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Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29 by Alcorlo, Martín, Luque-Ortega, Juan Román, Gago, Federico, Ortega, Alvaro, Castellanos, Milagros, Chacón, Pablo, de Vega, Miguel, Blanco, Luis, Hermoso, José M, Serrano, Manuel, Rivas, Germán, Hermoso, Juan A

“…Abstract The genome-organizing protein p6 of Bacillus subtilis bacteriophage φ29 plays an essential role in viral development by activating the initiation of…”
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How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function by Otero, Lisandro H., Rojas-Altuve, Alzoray, Llarrull, Leticia I., Carrasco-López, Cesar, Kumarasiri, Malika, Lastochkin, Elena, Fishovitz, Jennifer, Dawley, Matthew, Hesek, Dusan, Lee, Mijoon, Johnson, Jarrod W., Fisher, Jed F., Chang, Mayland, Mobashery, Shahriar, Hermoso, Juan A.

“…The expression of penicillin binding protein 2a (PBP2a) is the basis for the broad clinical resistance to the β-lactam antibiotics by methicillin-resistant…”
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Modulation of the lytic apparatus by the FtsEX complex within the bacterial division machinery by Alcorlo, Martín, Martínez-Caballero, Siseth, Li, Jianwei, Sham, Lok-To, Luo, Min, Hermoso, Juan A

“…The FtsEX membrane complex constitutes an essential component of the ABC transporter superfamily, widely distributed among bacterial species. It governs…”
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Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci by Alcorlo, Martín, Abdullah, Mohammed R, Steil, Leif, Sotomayor, Francisco, López-de Oro, Laura, de Castro, Sonia, Velázquez, Sonsoles, Kohler, Thomas P, Jiménez, Elisabet, Medina, Ana, Usón, Isabel, Keller, Lance E, Bradshaw, Jessica L, McDaniel, Larry S, Camarasa, María-José, Völker, Uwe, Hammerschmidt, Sven, Hermoso, Juan A

“…ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the…”
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Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site by Xu, Xin, Li, Jianwei, Chua, Wan-Zhen, Pages, Martin A, Shi, Jian, Hermoso, Juan A, Bernhardt, Thomas, Sham, Lok-To, Luo, Min

“…The peptidoglycan (PG) cell wall produced by the bacterial division machinery is initially shared between the daughters and must be split to promote cell…”
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A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha- and Betaproteobacteria by Espaillat, Akbar, Alvarez, Laura, Torrens, Gabriel, ter Beek, Josy, Miguel-Ruano, Vega, Irazoki, Oihane, Gago, Federico, Hermoso, Juan A., Berntsson, Ronnie P-A., Cava, Felipe

“…The bacterial cell-wall peptidoglycan is made of glycan strands crosslinked by short peptide stems. Crosslinks are catalyzed by DD-transpeptidases…”
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Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall by Straume, Daniel, Piechowiak, Katarzyna Wiaroslawa, Olsen, Silje, Stamsås, Gro Anita, Berg, Kari Helene, Kjos, Morten, Heggenhougen, Maria Victoria, Alcorlo, Martín, Hermoso, Juan A, Håvarstein, Leiv Sigve

“…In oval-shaped , septal and longitudinal peptidoglycan syntheses are performed by independent functional complexes: the divisome and the elongasome…”
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Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis by Mahasenan, Kiran V, Molina, Rafael, Bouley, Renee, Batuecas, María T, Fisher, Jed F, Hermoso, Juan A, Chang, Mayland, Mobashery, Shahriar

“…The mechanism of the β-lactam antibacterials is the functionally irreversible acylation of the enzymes that catalyze the cross-linking steps in the…”
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Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin by Flydal, Marte Innselset, Alcorlo-Pagés, Martín, Johannessen, Fredrik Gullaksen, Martínez-Caballero, Siseth, Skjærven, Lars, Fernandez-Leiroc, Rafael, Martinez, Aurora, Hermoso, Juan A.

“…Phenylalanine hydroxylase (PAH) is a key enzyme in the catabolism of phenylalanine, and mutations in this enzyme cause phenylketonuria (PKU), a genetic…”
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Discovery of Antibiotic (E)‑3-(3-Carboxy­phenyl)-2-(4-cyano­styryl)­quinazolin-4(3H)‑one by Bouley, Renee, Kumarasiri, Malika, Peng, Zhihong, Otero, Lisandro H, Song, Wei, Suckow, Mark A, Schroeder, Valerie A, Wolter, William R, Lastochkin, Elena, Antunes, Nuno T, Pi, Hualiang, Vakulenko, Sergei, Hermoso, Juan A, Chang, Mayland, Mobashery, Shahriar

“…In the face of the clinical challenge posed by resistant bacteria, the present needs for novel classes of antibiotics are genuine. In silico docking and…”
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The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus by Acebrón, Iván, Chang, Mayland, Mobashery, Shahriar, Hermoso, Juan A

“…The ability to resist the effect of a wide range of antibiotics makes methicillin-resistant Staphylococcus aureus (MRSA) a leading global human pathogen. A key…”
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Effect of Hopper Loading on the Formation of Alkyl Alcohols in Olive Fruits and Its Relationship with Sensory Quality Losses of Virgin Olive Oil by Boudebouz, Abdelaziz, Romero, Agustí, Hermoso, Juan-F, Boqué, Ricard, Mestres, Montserrat

“…The storage of olives in large hoppers is a widespread practice in oil mills, but these large volumes and their unloading can cause a physical deterioration of…”
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Comparing lettuce and cucumber production using hydroponics and aquaponic (tilapia) systems by Estrada-Perez, Nallely, Zavala-Leal, Iram, Gonzalez-Hermoso, Juan P, Ruiz-Velazco, Javier M.J

“…Aquaponics is the cultivation technique that integrates aquaculture with hydroponics. The present work compared two plant production cycles of a hydroponic…”
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DipM controls multiple autolysins and mediates a regulatory feedback loop promoting cell constriction in Caulobacter crescentus by Izquierdo-Martinez, Adrian, Billini, Maria, Miguel-Ruano, Vega, Hernández-Tamayo, Rogelio, Richter, Pia, Biboy, Jacob, Batuecas, María T., Glatter, Timo, Vollmer, Waldemar, Graumann, Peter L., Hermoso, Juan A., Thanbichler, Martin

“…Proteins with a catalytically inactive LytM-type endopeptidase domain are important regulators of cell wall-degrading enzymes in bacteria. Here, we study their…”
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