Search Results - "HERMANS, Karin G"

ID1 and ID3 Regulate the Self-Renewal Capacity of Human Colon Cancer-Initiating Cells through p21 by O'Brien, Catherine A., Kreso, Antonija, Ryan, Paul, Hermans, Karin G., Gibson, Lianne, Wang, Yadong, Tsatsanis, Andrew, Gallinger, Steven, Dick, John E.

“…There is increasing evidence that some cancers are hierarchically organized, sustained by a relatively rare population of cancer-initiating cells (C-ICs)…”
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells by Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

“…To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from…”
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A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal by Milyavsky, Michael, Gan, Olga I., Trottier, Magan, Komosa, Martin, Tabach, Ofer, Notta, Faiyaz, Lechman, Eric, Hermans, Karin G., Eppert, Kolja, Konovalova, Zhanna, Ornatsky, Olga, Domany, Eytan, Meyn, M. Stephen, Dick, John E.

“…Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration with protection from…”
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TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer by HERMANS, Karin G, VAN MARION, Ronald, VAN DEKKEN, Herman, JENSTER, Guido, VAN WEERDEN, Wytske M, TRAPMAN, Jan

“…Recently, a unique fusion between the prostate-specific, androgen-regulated TMPRSS2 gene and the ETS genes ERG, ETV1, or ETV4 has been described in clinical…”
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Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors by Wojtowicz, Edyta E., Lechman, Eric R., Hermans, Karin G., Schoof, Erwin M., Wienholds, Erno, Isserlin, Ruth, van Veelen, Peter A., Broekhuis, Mathilde J.C., Janssen, George M.C., Trotman-Grant, Aaron, Dobson, Stephanie M., Krivdova, Gabriela, Elzinga, Jantje, Kennedy, James, Gan, Olga I., Sinha, Ankit, Ignatchenko, Vladimir, Kislinger, Thomas, Dethmers-Ausema, Bertien, Weersing, Ellen, Alemdehy, Mir Farshid, de Looper, Hans W.J., Bader, Gary D., Ritsema, Martha, Erkeland, Stefan J., Bystrykh, Leonid V., Dick, John E., de Haan, Gerald

“…Umbilical cord blood (CB) is a convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However,…”
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Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML by Krivdova, Gabriela, Voisin, Veronique, Schoof, Erwin M., Marhon, Sajid A., Murison, Alex, McLeod, Jessica L., Gabra, Martino M., Zeng, Andy G.X., Aigner, Stefan, Yee, Brian A., Shishkin, Alexander A., Van Nostrand, Eric L., Hermans, Karin G., Trotman-Grant, Aaron C., Mbong, Nathan, Kennedy, James A., Gan, Olga I., Wagenblast, Elvin, De Carvalho, Daniel D., Salmena, Leonardo, Minden, Mark D., Bader, Gary D., Yeo, Gene W., Dick, John E., Lechman, Eric R.

“…Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties. However,…”
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Overexpression of Prostate-Specific TMPRSS2(exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer by HERMANS, Karin G, BOORMANS, Joost L, GASI, Delila, VAN LEENDERS, Geert J. H. L, JENSTER, Guido, VERHAGEN, Paul C. M. S, TRAPMAN, Jan

“…Purpose: To gain insight in the mechanism and clinical relevance of TMPRSS2-ERG expression in prostate cancer, we determined the specific characteristics of…”
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Truncated ETV1, Fused to Novel Tissue-Specific Genes, and Full-Length ETV1 in Prostate Cancer by HERMANS, Karin G, VAN DER KORPUT, Hetty A, KORSTEN, Hanneke, KRAAIJ, Robert, JENSTER, Guido, TRAPMAN, Jan, VAN MARION, Ronald, VAN DE WIJNGAART, Dennis J, ZIEL-VAN DER MADE, Angelique, DITS, Natasja F, BOORMANS, Joost L, VAN DER KWAST, Theo H, VAN DEKKEN, Herman, BANGMA, Chris H

“…In this study, we describe the properties of novel ETV1 fusion genes, encoding N-truncated ETV1 (dETV1), and of full-length ETV1, overexpressed in clinical…”
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Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines by Hermans, Karin G., van Alewijk, Dirk C., Veltman, Joris A., van Weerden, Wytske, van Kessel, Ad Geurts, Trapman, Jan

“…We examined 11 prostate cancer xenografts and 4 cell lines for chromosome 10 alterations. Conventional comparative genomic hybridization (CGH) and array‐based…”
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells by Lechman, Eric R., Gentner, Bernhard, Ng, Stanley W.K., Schoof, Erwin M., van Galen, Peter, Kennedy, James A., Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B., Takayama, Naoya, Dobson, Stephanie M., Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G., Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D., Zandstra, Peter W., Golub, Todd R., Ebert, Benjamin L., Lu, Jun, Minden, Mark, Wang, Jean C.Y., Naldini, Luigi, Dick, John E.

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Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer by Hermans, Karin G, Bressers, Anke A, van der Korput, Hetty A, Dits, Natasja F, Jenster, Guido, Trapman, Jan

“…Recently, fusion of ERG to the androgen-regulated, prostate-specific TMPRSS2 gene has been identified as the most frequent genetic alteration in prostate…”
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Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1 by Ernst, Daniel, Williams, Brent A., Wang, Xing-Hua, Yoon, Nara, Kim, Kyung-Phil, Chiu, Jodi, Luo, Zhi Juan, Hermans, Karin G., Krueger, Joerg, Keating, Armand

“…CD123 (IL-3Rα) is frequently expressed by malignant Hodgkin lymphoma (HL) cells. Naked monoclonal antibodies (mAb) against HL lack clinical benefit, partially…”
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Androgen receptor modifications in prostate cancer cells upon long‐termandrogen ablation and antiandrogen treatment by Marques, Rute B., Erkens‐Schulze, Sigrun, de Ridder, Corrina M., Hermans, Karin G., Waltering, Kati, Visakorpi, Tapio, Trapman, Jan, Romijn, Johannes C., van Weerden, Wytske M., Jenster, Guido

“…To study the mechanisms whereby androgen‐dependent tumors relapse in patients undergoing androgen blockade, we developed a novel progression model for prostate…”
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Androgen receptor modifications in prostate cancer cells upon long-term androgen ablation and antiandrogen treatment by MARQUES, Rute B, ERKENS-SCHULZE, Sigrun, DE RIDDER, Corrina M, HERMANS, Karin G, WALTERING, Kati, VISAKORPI, Tapio, TRAPMAN, Jan, ROMIJN, Johannes C, VAN WEERDEN, Wytske M, JENSTER, Guido

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Expression of the Androgen-Regulated Fusion Gene TMPRSS2-ERG Does Not Predict Response to Endocrine Treatment in Hormone-Naïve, Node-Positive Prostate Cancer by Boormans, Joost L, Hermans, Karin G, Made, Angelique C.J. Ziel-van der, van Leenders, Geert J.H.L, Wildhagen, Mark F, Collette, Laurence, Schröder, Fritz H, Trapman, Jan, Verhagen, Paul C.M.S

“…Abstract Background Fusion of the androgen-regulated gene transmembrane protease, serine 2, TMPRSS2 , to the v-ets erythroblastosis virus E26 oncogene homolog…”
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An activating mutation in AKT1 in human prostate cancer by Boormans, Joost L., Hermans, Karin G., van Leenders, Geert J.L.H., Trapman, Jan, Verhagen, Paul C.M.S.

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The Non-Hematopoietic Content in Paediatric Autologous Hematopoietic Stem Cell Grafts Is Skewed Towards Regulatory Myeloid and Exhausted Phenotypes by Geiger, Cora L, Koshyk, Alexandra, Harris, Taylor, Denney, Madison, Katrjian, Chant, Hermans, Karin G., Knight, Tristan E, Wall, Donna

“…Autologous hematopoietic stem cell transplant (aHSCT) is a central component of paediatric brain tumours and high-risk neuroblastoma management. Standardly,…”
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Deletion of chromosomal region 6q14‐16 in prostate cancer by Verhagen, Paul C.M.S., Hermans, Karin G.L., Brok, Mariel O., van Weerden, Wytzke M., Tilanus, Marcel G.J., de Weger, Roel A., Boon, Tom A., Trapman, Jan

“…A detailed analysis of chromosome 6 in DNAs from prostate cancers was performed, to define a region for subsequent search for cancer genes. DNA from 4 prostate…”
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G-CSF Use in Mobilization and Post-Hematopoietic Stem Cell Transplant Induces Regulatory Myeloid Populations by McCartney, Erika, Snelling, Shannon, Denney, Madison, Kung, Raymond, Rachel, Marie, Yang, Zi Fan, Guan, Qing Dong, Hermans, Karin G., Wall, Donna A.

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Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3 by Liu, Qiang, Gan, Olga I., Krivdova, Gabriela, Trotman-Grant, Aaron, Dobson, Stephanie M., Hermans, Karin G., Minden, Mark D., Izraeli, Shai, Dick, John E., Wang, Jean C.Y., Lechman, Eric R.

“…Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor survival, especially in older patients. Despite high remission rates after…”
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