Search Results - "HERING, Bernhard J"

Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia by Choudhary, Pratik, Rickels, Michael R, Senior, Peter A, Vantyghem, Marie-Christine, Maffi, Paola, Kay, Thomas W, Keymeulen, Bart, Inagaki, Nobuya, Saudek, Frantisek, Lehmann, Roger, Hering, Bernhard J

“…Problematic hypoglycemia, defined as two or more episodes per year of severe hypoglycemia or as one episode associated with impaired awareness of hypoglycemia,…”
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Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system by Matson, Anders W, Hosny, Nora, Swanson, Zachary A, Hering, Bernhard J, Burlak, Christopher

“…The CRISPR/Cas9 gene editing system has enhanced the development of genetically engineered animals for use in xenotransplantation. Potential limitations to the…”
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High-mannose type N-glycans with core fucosylation and complex-type N-glycans with terminal neuraminic acid residues are unique to porcine islets by Nanno, Yoshihide, Shajahan, Asif, Sonon, Roberto N, Azadi, Parastoo, Hering, Bernhard J, Burlak, Christopher

“…Islet transplantation is an emerging treatment option for type 1 diabetes but its application is limited by the shortage of human pancreas donors…”
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Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes by Singh, Amar, Ramachandran, Sabarinathan, Graham, Melanie L., Daneshmandi, Saeed, Heller, David, Suarez-Pinzon, Wilma Lucia, Balamurugan, Appakalai N., Ansite, Jeffrey D., Wilhelm, Joshua J., Yang, Amy, Zhang, Ying, Palani, Nagendra P., Abrahante, Juan E., Burlak, Christopher, Miller, Stephen D., Luo, Xunrong, Hering, Bernhard J.

“…Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively…”
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Carbohydrate antigen microarray analysis of serum IgG and IgM antibodies before and after adult porcine islet xenotransplantation in cynomolgus macaques by Nanno, Yoshihide, Sterner, Eric, Gildersleeve, Jeffrey C, Hering, Bernhard J, Burlak, Christopher

“…Understanding the anti-carbohydrate antibody response toward epitopes expressed on porcine cells, tissues, and organs is critical to advancing…”
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Factors Predicting Outcomes After a Total Pancreatectomy and Islet Autotransplantation Lessons Learned From Over 500 Cases by Chinnakotla, Srinath, Beilman, Gregory J, Dunn, Ty B, Bellin, Melena D, Freeman, Martin L, Radosevich, David M, Arain, Mustafa, Amateau, Stuart K, Mallery, J Shawn, Schwarzenberg, Sarah J, Clavel, Alfred, Wilhelm, Joshua, Robertson, R Paul, Berry, Louise, Cook, Marie, Hering, Bernhard J, Sutherland, David E.R, Pruett, Timothy L

“…OBJECTIVE:Our objective was to analyze factors predicting outcomes after a total pancreatectomy and islet autotransplantation (TP-IAT). BACKGROUND:Chronic…”
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2008 Update From the Collaborative Islet Transplant Registry by ALEJANDRO, Rodolfo, BARTON, Franca B, HERING, Bernhard J, WEASE, Steve

“…This report summarizes the primary efficacy and the safety outcomes of islet transplantation reported to the NIDDK and JDRF funded Collaborative Islet…”
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Regulation of Clinical Xenotransplantation—Time for a Reappraisal by Cooper, David K.C, Pierson, Richard N, Hering, Bernhard J, Mohiuddin, Muhammad M, Fishman, Jay A, Denner, Joachim, Ahn, Curie, Azimzadeh, Agnes M, Buhler, Leo H, Cowan, Peter J, Hawthorne, Wayne J, Kobayashi, Takaaki, Sachs, David H

“…ABSTRACTThe continual critical shortage of organs and cells from deceased human donors has stimulated research in the field of cross-species transplantation…”
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Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes by Yu, Ming, Agarwal, Divyansh, Korutla, Laxminarayana, May, Catherine L., Wang, Wei, Griffith, Negin Noorchashm, Hering, Bernhard J., Kaestner, Klaus H., Velazquez, Omaida C., Markmann, James F., Vallabhajosyula, Prashanth, Liu, Chengyang, Naji, Ali

“…The intrahepatic milieu is inhospitable to intraportal islet allografts 1 – 3 , limiting their applicability for the treatment of type 1 diabetes. Although the…”
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Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques by Graham, Melanie L., Ramachandran, Sabarinathan, Singh, Amar, Moore, Meghan E. G., Flanagan, E. Brian, Azimzadeh, Agnes, Burlak, Christopher, Mueller, Kate R., Martins, Kyra, Anazawa, Takayuki, Appakalai, Balamurugan N., Bansal‐Pakala, Pratima, Murtaugh, Michael P., O'Brien, Timothy D., Papas, Klearchos K., Spizzo, Thomas, Schuurman, Henk‐J., Hancock, Wayne W., Hering, Bernhard. J.

“…A safe, efficacious, and clinically applicable immunosuppressive regimen is necessary for islet xenotransplantation to become a viable treatment option for…”
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Serum cytokine profiles in healthy nonhuman primates are blunted by sedation and demonstrate sexual dimorphism as detected by a validated multiplex immunoassay by Hocum Stone, Laura, Oppler, Scott Hunter, Nugent, Julia L., Gresch, Sarah, Hering, Bernhard J., Murtaugh, Michael P., Hegstad-Davies, Rebecca L., Ramachandran, Sabarinathan, Graham, Melanie L.

“…Cytokine profiling is a valuable tool for monitoring immune responses associated with disease and treatment. This study assessed the impact of sex and sedation…”
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Peri-Transplant Inflammation and Long-Term Diabetes Outcomes Were Not Impacted by Either Etanercept or Alpha-1-Antitrypsin Treatment in Islet Autotransplant Recipients by Abdel-Karim, Tasneem R, Hodges, James S, Herold, Kevan C, Pruett, Timothy L, Ramanathan, Karthik V, Hering, Bernhard J, Dunn, Ty B, Kirchner, Varvara A, Beilman, Gregory J, Bellin, Melena D

“…The instant blood-mediated inflammatory response (IBMIR) causes islet loss and compromises diabetes outcomes after total pancreatectomy with islet…”
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Antiapoptotic Actions of Exendin-4 against Hypoxia and Cytokines Are Augmented by CREB by Velmurugan, Kalpana, Balamurugan, A. N, Loganathan, Gopalakrishnan, Ahmad, Aftab, Hering, Bernhard J, Pugazhenthi, Subbiah

“…Islets isolated from cadaveric donor pancreas are functionally viable and can be transplanted in diabetic patients to reduce insulin requirements. This…”
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HLA-G1 + Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses by Rao, Joseph Sushil, Hosny, Nora, Kumbha, Ramesh, Naqvi, Raza Ali, Singh, Amar, Swanson, Zachary, Levy, Heather, Matson, Anders W, Steinhoff, Magie, Forneris, Nicole, Walters, Eric, Hering, Bernhard J, Burlak, Christopher

“…The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility complex (MHC-I) protein, is a potent immunomodulatory molecule at the…”
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Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates by Hering, Bernhard J, Wijkstrom, Martin, Graham, Melanie L, Hårdstedt, Maria, Aasheim, Tor C, Jie, Tun, Ansite, Jeffrey D, Nakano, Masahiko, Cheng, Jane, Li, Wei, Moran, Kathleen, Christians, Uwe, Finnegan, Colleen, Mills, Charles D, Sutherland, David E, Bansal-Pakala, Pratima, Murtaugh, Michael P, Kirchhof, Nicole, Schuurman, Henk-Jan

“…Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal…”
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First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary by Hering, Bernhard J., Cozzi, Emanuele, Spizzo, Thomas, Cowan, Peter J., Rayat, Gina R., Cooper, David K.C., Denner, Joachim

“…The International Xenotransplantation Association has updated its original “Consensus Statement on Conditions for Undertaking Clinical Trials of Porcine Islet…”
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A New Enzyme Mixture to Increase the Yield and Transplant Rate of Autologous and Allogeneic Human Islet Products by BALAMURUGAN, A. N, LOGANATHAN, Gopalakrishnan, PAPAS, Klearchos K, MCCARTHY, Robert, SUTHERLAND, David E. R, HERING, Bernhard J, BELLIN, Melena D, WILHELM, Joshua J, HARMON, James, ANAZAWA, Takayuki, SOLTANI, Sajjad M, RADOSEVICH, David M, YUASA, Takeshi, TIWARI, Mukesh

“…The optimal enzyme blend that maximizes human islet yield for transplantation remains to be determined. In this study, we evaluated eight different enzyme…”
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Long-term Outcomes for Living Pancreas Donors in the Modern Era by Kirchner, Varvara A, Finger, Erik B, Bellin, Melena D, Dunn, Ty B, Gruessner, Rainer W.G, Hering, Bernhard J, Humar, Abhinav, Kukla, Aleksandra K, Matas, Arthur J, Pruett, Timothy L, Sutherland, David E.R, Kandaswamy, Raja

“…BACKGROUNDLiving donor segmental pancreas transplants (LDSPTx) have been performed selectively to offer a preemptive transplant option for simultaneous…”
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Islet Autotransplant Outcomes After Total Pancreatectomy : A Contrast to Islet Allograft Outcomes by SUTHERLAND, David E. R, GRUESSNER, Angelika C, CARLSON, Annelisa M, BLONDET, Juan J, BALAMURUGAN, A. N, REIGSTAD, Katie F, BEILMAN, Gregory J, BERLIN, Melena D, HERING, Bernhard J

“…Islet allografts are currently associated with a high rate of early insulin independence, but after 1 year insulin-independence rates rapidly decline for…”
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The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis by Blondet, Juan J., MD, Carlson, Annelisa M., MD, Kobayashi, Takashi, MD, Jie, Tun, MD, Bellin, Melena, MD, Hering, Bernhard J., MD, Freeman, Martin L., MD, Beilman, Greg J., MD, Sutherland, David E.R., MD, PhD

“…Total pancreatectomy and islet autotransplantation are done for chronic pancreatitis with intractable pain when other treatment measures have failed, allowing…”
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