Search Results - "HERBERT, T. P"

Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2) by Barlow, A. D., Xie, J., Moore, C. E., Campbell, S. C., Shaw, J. A. M., Nicholson, M. L., Herbert, T. P.

“…Aims/hypothesis Rapamycin (sirolimus) is one of the primary immunosuppressants for islet transplantation. Yet there is evidence that the long-term treatment of…”
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : A specific vascular action of insulin by KUBOKI, K, JIANG, Z. Y, TAKAHARA, N, SUNGWOOHA, IGARASHI, M, YAMAUCHI, T, FEENER, E. P, HERBERT, T. P, RHODES, C. J, KING, G. L

“…The vasodilatory effect of insulin can be acute or increase with time from 1 to 7 hours, suggesting that insulin may enhance the expression of endothelial…”
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Identification of a protein linked to the genomic and subgenomic mRNAs of feline calicivirus and its role in translation by Herbert, TP, Brierley, I, Brown, TD

“…TP Herbert, I Brierley and TD Brown Department of Pathology, University of Cambridge, UK. 125I protein labelling of oligo(dT)-selected RNA from feline…”
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Detection of the ORF3 polypeptide of feline calicivirus in infected cells and evidence for its expression from a single, functionally bicistronic, subgenomic mRNA by Herbert, T. P, Brierley, I, Brown, T. D. K

“…Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK Feline calicivirus (FCV) is a small…”
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PERK in the life and death of the pancreatic beta-cell by Herbert, T P

“…To ensure cellular survival to ER (endoplasmic reticulum) stress, PERK [PKR (double-stranded-RNA-dependent protein kinase)-like ER kinase], an ER transmembrane…”
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ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes by Omikorede, O, Qi, C, Gorman, T, Chapman, P, Yu, A, Smith, D M, Herbert, T P

“…Objective: The objective of this study was to determine whether ER stress correlates with β-cell dysfunction in obesity-associated diabetes. Methods:…”
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Cooperativity between the Preproinsulin mRNA Untranslated Regions Is Necessary for Glucose-stimulated Translation by Wicksteed, Barton, Herbert, Terence P., Alarcon, Cristina, Lingohr, Melissa K., Moss, Larry G., Rhodes, Christopher J.

“…Glucose regulates proinsulin biosynthesis via stimulation of the translation of the preproinsulin mRNA in pancreatic β-cells. However, the mechanism by which…”
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Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells by Herbert, Terence P., Kilhams, Gordon R., Batty, Ian H., Proud, Christopher G.

“…Stimulation of serum-starved human embryonic kidney (HEK) 293 cells with either the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), or insulin…”
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Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E by Herbert, Terence P, Fåhraeus, Robin, Prescott, Alan, Lane, David P, Proud, Chris G

“…Overexpression of the translation initiation factor eIF4E leads to cell transformation and occurs in a number of human cancers [1]. mRNA translation and cell…”
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The mouse Y-box protein, MSY2, is associated with a kinase on non-polysomal mouse testicular mRNAs by Herbert, Terence P., Hecht, Norman B.

“…In male germ cells many mRNAs are sequestered by proteins into translationally silent messenger ribonucleoprotein (mRNP) particles. These masked paternal mRNAs…”
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Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K +-channel activity in insulin-secreting cells by Köhler, Martin, Norgren, Svante, Berggren, Per-Olof, Fredholm, Bertil B, Larsson, Olof, Rhodes, Christopher J, Herbert, Terence P, Luthman, Holger

“…Changes in cytoplasmic ATP concentration were monitored in intact insulin-producing cells and correlated to changes in the activity of ATP-sensitive K…”
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Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic b-Cells by Moore, CEJ, Xie, J, Gomez, E, Herbert, T P

“…Ribosomal protein S6 (rpS6) is phosphorylated in vivo by isoforms of p70 S6 protein kinase and p90 ribosomal S6 kinase, and there is good evidence that it…”
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Lake Bosumtwi, Ashanti by Rohleder, Herbert P. T.

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The Nebiewale Caldera, Gold Coast by Rohleder, Herbert P. T.

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cAMP-dependent Protein Kinase and Ca super(2+) Influx through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic [beta]-Cells by Gomez, E, Pritchard, C, Herbert, T P

“…Glucagon like peptide-1 (GLP1) is a G sub(s)-coupled receptor agonist that exerts multiple effects on pancreatic [beta]-cells, including the stimulation of…”
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cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells by Gomez, Edith, Pritchard, Catrin, Herbert, Terence P

“…Glucagon like peptide-1 (GLP1) is a G(s)-coupled receptor agonist that exerts multiple effects on pancreatic beta-cells, including the stimulation of insulin…”
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The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites by Herbert, Terence P., Tee, Andrew R., Proud, Christopher G.

“…The phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent stimulator of Erk, leads to the phosphorylation of 4E-BP1 and its dissociation from…”
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Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α by Gomez, Edith, Powell, Michael L., Greenman, Isabel C., Herbert, Terence P.

“…In pancreatic β-cells, glucose causes a rapid increase in the rate of protein synthesis. However, the mechanism by which this occurs is poorly understood. In…”
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African Elephants as Geological Indicators by HYDE, HERBERT P. T

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Letter from Herbert P. T. Hyde by Herbert P. T. Hyde

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