Search Results - "HENZE, Marcus"

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice by Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.

“…Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on…”
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Simultaneous integration of telemetered left-ventricular pressure and echocardiography in rats: Minimally-invasive serial pressure-volume relationships in the setting of normal and impaired diastolic function by del Rio, Carlos L., Zambataro, Christopher, Bogie, Heather, Yucel, A.J., Ferguson, Brain, Henze, Marcus P., Fernandes, Sarah, Evanchik, Marc J.

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Persistent alterations in heart rate variability, baroreflex sensitivity, and anxiety-like behaviors during development of heart failure in the rat by Henze, Marcus, Hart, Davin, Samarel, Allen, Barakat, John, Eckert, Laurie, Scrogin, Karie

“…Depressed heart rate variability and mood are associated with increased mortality in patients with congestive heart failure (CHF). Here autonomic indexes were…”
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Bihemispheric Cerebral FDG PET Correlates of Cognitive Dysfunction as Assessed by the CERAD in Alzheimer's Disease by Schönknecht, Oskar Dieter Peter, Hunt, Aoife, Toro, Pablo, Guenther, Thomas, Henze, Marcus, Haberkorn, Uwe, Schröder, Johannes

“…Alzheimer's disease (AD) is characterized by a variety of cognitive deficits which can be reliably assessed by the neuropsychological test battery of the…”
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CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling by Hart, Davin L, Heidkamp, Maria C, Iyengar, Rekha, Vijayan, Kalpana, Szotek, Erika L, Barakat, John A, Leya, Marysa, Henze, Marcus, Scrogin, Karie, Henderson, Kyle K, Samarel, Allen M

“…Abstract PYK2 is a Ca2+ -dependent, nonreceptor protein tyrosine kinase that is involved in the induction of left ventricular hypertrophy (LVH) and its…”
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Integration of Troponin I Phosphorylation With Cardiac Regulatory Networks by Solaro, R John, Henze, Marcus, Kobayashi, Tomoyoshi

“…We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation as an integral and adaptive mechanism in cardiac homeostasis…”
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The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium by Ma, Weikang, Henze, Marcus, Anderson, Robert L., Gong, Henry, Wong, Fiona L., del Rio, Carlos L., Irving, Thomas

“…[Figure: see text]…”
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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers by Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.

“…Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However,…”
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Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine by Gutschalk, Alexander, Kollmar, Rainer, Mohr, Alexander, Henze, Marcus, Ille, Nicole, Schwaninger, Markus, Hartmann, Marius, Hähnel, Stefan, Haberkorn, Uwe, Rupp, André, Meyding-Lamade, Uta

“…The case of a patient with familial hemiplegic migraine (FHM) suffering from prolonged right sided hemiparesis and aphasia that persisted for more than 10 days…”
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Abstract We094: Acute Administration of The Novel Cardiac Sarcomere Modulator EDG-7500, Improves Ventricular Filling While Preserving LVEF In Dogs with Pacing Induced Left-Ventricular Systolic Dysfunction by Evanchik, Marc, Emter, Craig, Del Rio, carlos, Roof, Steve, St Clair, Sydney, Russell, Alan, Henze, Marcus, Semigran, marc

“…Abstract only Introduction: EDG-7500 is a cardiac sarcomere modulator that has been shown to slow early LV contraction and to improve diastolic filling,…”
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Abstract 4142919: Chronic administration of EDG-7500, a novel sarcomere modulator, prevents increases in cardiac mass, T1 relaxation time, and left ventricular end diastolic pressure in a Yucatan mini-pig model of genetic non-obstructive hypertrophic cardiomyopathy by Emter, Craig, Lehman, Sarah, Lee, Lindsey, DiNatale, Emy, Peter, Angela, Henze, Marcus, Bluemke, David, Tharp, Darla, Roof, Steve, del Rio, Carlos, Semigran, marc, Russell, Alan, Evanchik, Marc

“…Abstract only Introduction: Pathologic cardiac remodeling is a hallmark of hypertrophic cardiomyopathy (HCM). EDG-7500 is a novel oral, selective cardiac…”
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CHRONIC TREATMENT WITH THE NOVEL SARCOMERE MODULATOR EDG-7500 IMPROVES LEFT VENTRICULAR DISTENSIBILITY AND CARDIAC OUTPUT RECRUITMENT UNDER STRESS IN A MINIPIG GENETIC MODEL OF NON-OBSTRUCTED HYPERTROPHIC CARDIOMYOPATHY by Evanchik, Marc, Emter, Craig, del Rio, Carlos L., Dinatale, Emily, Henze, Marcus, Roof, Steve, St Clair, Sydney, Lee, Lindsey, Peter, Angela, Russell, Alan, Semigran, Marc J.

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Reduction of global longitudinal strain in rats with diastolic dysfunction and preserved ejection fraction: comparison against post-mi rats with reduced ejection fraction by Zambataro, Christopher A., Ferguson, Brian S., Shimkunas, Rafael, Tobia, Steven, Henze, Marcus, Del Rio, Carlos L.

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Abstract 905: Length Dependent Activation in Porcine Cardiac Myofilaments is Modulated by Mavacamten by Henze, Marcus, Ma, Weikang, Wong, Fiona, Gong, Henry, Anderson, Robert, del Rio, Carlos, Irving, Thomas C

“…Abstract only Length dependent activation (LDA) is a property of muscle where increased sarcomere length (SL) leads to increased force of contraction. Despite…”
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Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure by Henze, Marcus, Tiniakov, Ruslan, Samarel, Allen, Holmes, Earle, Scrogin, Karie

“…Up to 40% of patients with heart failure develop depression, and depression is an independent risk factor for cardiovascular mortality in this patient…”
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Abstract 13952: A Novel Genetic Mini-Pig Model of Cardiac Myosin-Binding Protein C (MYBPC3) Dysfunction: Evidence for Altered Sarcomere Structure and Systolic/Diastolic Functional Reserve in vivo by del Rio, Carlos L, Ma, Weikang, Ryba, David, Gong, Henry, Henze, Marcus, Gollapudi, Sampath K, Anderson, Robert, Nag, Suman, Rogers, Christopher, Irving, Thomas

“…IntroductionMutations in MYPBC3, the gene encoding cardiac Myosin-Binding Protein C (cMyBP-C), a regulatory sarcomeric protein, are known to play a pathogenic…”
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Myofilament Length Dependent Activation in Porcine Cardiac Muscle by Ma, Weikang, Anderson, Robert, Henze, Marcus, Gong, Henry, Wong, Fiona, del Rio, Carlos, Irving, Thomas

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Abstract 17492: Chronic Treatment With a Mavacamten-Like Myosin-Modulator (MYK-581) Prevents Left-Atrial Remodeling, Decreases Cardiac Troponin Leakage, and Blunts Mortality in a Mini-Pig Model of Inherited Hypertrophic Cardiomyopathy by Bell, Kaylyn M, Ryba, David M, Smit, Trisha, Rohret, Frank, Chin, Daniel, Hollenbeck, Emily, Shahidi-Latham, Sheerin, Henze, Marcus, del Rio, Carlos L

“…IntroductionHypertrophic cardiomyopathy (HCM) is a progressive disease characterized by cardiac remodeling, impaired relaxation, left-atrial enlargement, and…”
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Isoflurane Anesthesia Masks Elevated Filling Pressures in Hypertensive Rats with Diastolic Dysfunction and Preserved Ejection Fraction: Comparison to Ketamine/Xylaxine Sedation by Zambataro, Christopher A., Ferguson, Brian S., Henze, Marcus P., Evanchik, Marc J., Del Rio, Carlos L.

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Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial by Voors, Adriaan A., Tamby, Jean‐François, Cleland, John G., Koren, Michael, Forgosh, Leslie B., Gupta, Dinesh, Lund, Lars H., Camacho, Albert, Karra, Ravi, Swart, Henk P., Pellicori, Pierpaolo, Wagner, Frank, Hershberger, Ray E., Prasad, Narayana, Anderson, Robert, Anto, Anu, Bell, Kaylyn, Edelberg, Jay M., Fang, Liang, Henze, Marcus, Kelly, Cynthia, Kurio, Gregory, Li, Wanying, Wells, Kate, Yang, Chun, Teichman, Sam L., Rio, Carlos L., Solomon, Scott D.

“…Aims Both left ventricular (LV) and left atrial (LA) dysfunction and remodelling contribute to adverse outcomes in heart failure with reduced ejection fraction…”
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