Search Results - "HENRIQUES, JOÃO ANTONIO PÊGAS"

Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone by Damiani, Roberto Marques, Moura, Dinara Jaqueline, Viau, Cassiana Macagnan, Caceres, Rafael Andrade, Henriques, João Antonio Pêgas, Saffi, Jenifer

“…Anthracyclines, e.g., doxorubicin (DOX), and anthracenediones, e.g., mitoxantrone (MTX), are drugs used in the chemotherapy of several cancer types, including…”
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Replication and Homologous Recombination Repair Regulate DNA Double-Strand Break Formation by the Antitumor Alkylator Ecteinascidin 743 by Soares, Daniele Grazziotin, Escargueil, Alexandre E., Poindessous, Virginie, Sarasin, Alain, de Gramont, Aimery, Bonatto, Diego, Henriques, João Antonio Pêgas, Larsen, Annette K.

“…Adducts induced by the antitumor alkylator ecteinascidin 743 (ET-743, Yondelis, trabectedin) represent a unique challenge to the DNA repair machinery because…”
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The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability by Pêgas Henriques, João Antonio, Bergter, Lothar, Bordin, Diana Lilian, Machado, Miriana, de Oliveira, Iuri Marques, Arigony, Ana Lúcia Vargas, Prá, Daniel

“…Micronutrients, including minerals and vitamins, are indispensable to DNA metabolic pathways and thus are as important for life as macronutrients. Without the…”
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Novel Keratinase from Bacillus subtilis S14 Exhibiting Remarkable Dehairing Capabilities by Macedo, Alexandre J, da Silva, Walter O. Beys, Gava, Renata, Driemeier, David, Henriques, João Antonio Pêgas, Termignoni, Carlos

“…We report the isolation of a keratinolytic-producing Bacillus subtilis strain and the characterization of the exceptional dehairing properties of its…”
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Saccharomyces cerevisiae as a model system to study the response to anticancer agents by Matuo, Renata, Sousa, Fabrício G., Soares, Daniele G., Bonatto, Diego, Saffi, Jenifer, Escargueil, Alexandre E., Larsen, Annette K., Henriques, João Antonio Pêgas

“…The development of new strategies for cancer therapeutics is indispensable for the improvement of standard protocols and the creation of other possibilities in…”
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Genotoxicity and mutagenicity of iron and copper in mice by Prá, Daniel, Franke, Silvia Isabel Rech, Giulian, Raquel, Yoneama, Maria Lúcia, Dias, Johnny Ferraz, Erdtmann, Bernardo, Henriques, João Antonio Pêgas

“…The toxicity of trace metals is still incompletely understood. We have previously shown that a single oral dose of iron or copper induces genotoxic effects in…”
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New insights into the Ca2+-ATPases that contribute to cadmium tolerance in yeast by Mielniczki-Pereira, Albanin Aparecida, Hahn, Ana Bárbara Barth, Bonatto, Diego, Riger, Cristiano Jorge, Eleutherio, Elis Cristina Araujo, Henriques, João Antonio Pêgas

“…► Inactivation of the PMR1 gene in Saccharomyces cerevisiae delayed initial cadmium uptake. ► Cells lacking functional Pmr1p increased basal expression of PMC1…”
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Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration by Manuel, Raoul, Lima, Michelle de Souza, Dilly, Sébastien, Daunay, Sylvain, Abbe, Patricia, Pramil, Elodie, Solier, Stéphanie, Guillaumond, Fabienne, Tubiana, Sarah-Simha, Escargueil, Alexandre, Pêgas Henriques, João Antonio, Ferrand, Nathalie, Erdelmeier, Irène, Boucher, Jean-Luc, Bertho, Gildas, Agranat, Israel, Rocchi, Stéphane, Sabbah, Michèle, Slama Schwok, Anny

“…Specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS), two enzymes associated with redox stress in tumor cells, has aroused great pharmacological…”
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DNA repair pathways involved in repair of lesions induced by 5-fluorouracil and its active metabolite FdUMP by Matuo, Renata, Sousa, Fabrício Garmus, Escargueil, Alexandre E., Soares, Daniele G., Grivicich, Ivana, Saffi, Jenifer, Larsen, Annette K., Henriques, João Antonio Pêgas

“…A systematic study in Saccharomyces cerevisiae reveals important differences in the repair of DNA lesions induced by 5-flourouracil and its major metabolite,…”
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Pmr1 protein, the major yeast Ca²⁺-ATPase in the Golgi, regulates intracellular levels of the cadmium ion by Lauer Júnior, Cláudio Marcos, Bonatto, Diego, Mielniczki-Pereira, Albanin Aparecida, Zilles Schuch, Ana, Dias, Johnny Ferraz, Yoneama, Maria-Lúcia, Henriques, João Antonio Pêgas

“…Cadmium is a nonessential, highly toxic heavy metal that shows ionic properties similar to calcium. These ionic similarities imply that the cadmium ion, Cd²⁺,…”
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role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae by de Oliveira, Iuri Marques, Zanotto-Filho, Alfeu, Moreira, José Cláudio Fonseca, Bonatto, Diego, Henriques, João Antonio Pêgas

“…The nitroreductase family is comprised of a group of FMN- or FAD-dependent enzymes that are able to metabolize nitrosubstituted compounds using the reducing…”
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Red propolis:Chemical composition and pharmacological activity by Rufatto, Luciane Corbellini, dos Santos, Denis Amilton, Marinho, Flávio, Henriques, João Antonio Pêgas, Roesch Ely, Mariana, Moura, Sidnei

“…Propolis has been used worldwide for years in folk medicine and currently marketed by the pharmaceutical industry. In Brazil, propolis was classified into 13…”
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Antioxidant defences and haemocyte internalization in Limnoperna fortunei exposed to TiO2 nanoparticles by Girardello, Francine, Leite, Camila Custódio, Branco, Catia Santos, Roesch-Ely, Mariana, Fernandes, Andreia Neves, Salvador, Mirian, Henriques, João Antonio Pêgas

“…•TiO2-NP was internalized by Limnoperna fortunei cells.•TiO2-NP can promote alterations in haemocytes membrane of golden mussel.•Antioxidant activity of Sod…”
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DNA damage in organs of mice treated acutely with patulin, a known mycotoxin by de Melo, Flávia Terezinha, de Oliveira, Iuri Marques, Greggio, Samuel, Dacosta, Jaderson Costa, Guecheva, Temenouga Nikolova, Saffi, Jenifer, Henriques, João Antonio Pêgas, Rosa, Renato Moreira

“…► Genotoxic effect of patulin after systemic administration was evaluated in mice. ► Dose-dependent increase in DNA strand breaks (brain, liver, kidneys) was…”
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ZnO nanoparticles alter redox metabolism of Limnoperna fortunei by Girardello, Francine, Leite, Camila Custódio, Touguinha, Luciana Bavaresco, Roesch-Ely, Mariana, da Silva, Chrys Katielli Hoinacki, de Oliveira, Richard Macedo, Borges, Daniel Lazaro Gallindo, Villela, Izabel Vianna, Fernandes, Andreia Neves, Salvador, Mirian, Henriques, João Antonio Pêgas

“…Nanoparticles such as zinc oxide nanoparticles (ZnO-NP) that are incorporated in consumer and industrial products have caused concern about their potential…”
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Relationship between endoplasmic reticulum- and Golgi-associated calcium homeostasis and 4-NQO-induced DNA repair in Saccharomyces cerevisiae by Poletto, Nadine Paese, Henriques, João Antonio Pêgas, Bonatto, Diego

“…Calcium (Ca²⁺) is an important ion that is necessary for the activation of different DNA repair mechanisms. However, the mechanism by which DNA repair and Ca²⁺…”
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Piperlongumine Induces Apoptosis in Colorectal Cancer HCT 116 Cells Independent of Bax, p21 and p53 Status by DA Silva Machado, Fernanda, Munari, Fernanda Mosena, Scariot, Fernando Joel, Echeverrigaray, Sergio, Aguzzoli, Cesar, Pich, Claus Tröger, Kato, Massuo Jorge, Yamaguchi, Lydia, Moura, Sidnei, Henriques, João Antonio Pêgas, Roesch-Ely, Mariana

“…Colorectal cancer is a common type of cancer with reported resistance to treatment, in most cases due to loss of function of apoptotic and cell-cycle proteins…”
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Influence of orange juice over the genotoxicity induced by alkylating agents: an in vivo analysis by Franke, Silvia Isabel Rech, Prá, Daniel, Erdtmann, Bernardo, Henriques, João Antonio Pêgas, da Silva, Juliana

“…There is considerable epidemiological evidence indicating an association between diets rich in fresh fruit and vegetables and a decreased incidence of cancers…”
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Possible Link Between Iron Deficiency and Gastrointestinal Carcinogenesis by Pra, Daniel, Franke, Silvia Isabel Rech, Henriques, Joao Antonio Pegas, Fenech, Michael

“…There is definitive evidence that iron overload induces oxidative stress and DNA damage, which can enhance carcinogenic risk. However, other evidence suggests…”
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Dietary total antioxidant capacity is associated with plasmatic antioxidant capacity, nutrient intake and lipid and DNA damage in healthy women by Stedile, Natalia, Canuto, Raquel, Col, Camila Dallavechia de, Sene, Juliane Souza de, Stolfo, Adriana, Wisintainer, Gabrielle Nunes de Souza, Henriques, João Antonio Pêgas, Salvador, Mirian

“…Dietary total antioxidant capacity (DTAC) seems to be associated with reducing risk of diseases. However, data about the influence of the DTAC on oxidative…”
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