Search Results - "HENRIK GAD, Hans"

Mapping of Chikungunya Virus Interactions with Host Proteins Identified nsP2 as a Highly Connected Viral Component by BOURAÏ, Mehdi, LUCAS-HOURANI, Marianne, LECUIT, Marc, ANDRE, Patrice, MAREIKE KÜMMERER, Beate, LOTTEAU, Vincent, DESPRES, Philippe, TANGY, Frederic, VIDALAIN, Pierre-Olivier, HENRIK GAD, Hans, DROSTEN, Christian, JACOB, Yves, TAFFOREAU, Lionel, CASSONNET, Patricia, JONES, Louis M, JUDITH, Delphine, COUDERC, Therese

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of SARS–CoV-2 by type I and type III interferons by Felgenhauer, Ulrike, Schoen, Andreas, Gad, Hans Henrik, Hartmann, Rune, Schaubmar, Andreas R., Failing, Klaus, Drosten, Christian, Weber, Friedemann

“…The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic…”
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Type I and III interferons disrupt lung epithelial repair during recovery from viral infection by Major, Jack, Crotta, Stefania, Llorian, Miriam, McCabe, Teresa M, Gad, Hans Henrik, Priestnall, Simon L, Hartmann, Rune, Wack, Andreas

“…Excessive cytokine signaling frequently exacerbates lung tissue damage during respiratory viral infection. Type I (IFN-α and IFN-β) and III (IFN-λ) interferons…”
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IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission by Klinkhammer, Jonas, Schnepf, Daniel, Ye, Liang, Schwaderlapp, Marilena, Gad, Hans Henrik, Hartmann, Rune, Garcin, Dominique, Mahlakõiv, Tanel, Staeheli, Peter

“…Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN)…”
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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment by Davidson, Sophia, McCabe, Teresa M, Crotta, Stefania, Gad, Hans Henrik, Hessel, Edith M, Beinke, Soren, Hartmann, Rune, Wack, Andreas

“…Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury. Since type I…”
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Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses by Holm, Christian K., Rahbek, Stine H., Gad, Hans Henrik, Bak, Rasmus O., Jakobsen, Martin R., Jiang, Zhaozaho, Hansen, Anne Louise, Jensen, Simon K., Sun, Chenglong, Thomsen, Martin K., Laustsen, Anders, Nielsen, Camilla G., Severinsen, Kasper, Xiong, Yingluo, Burdette, Dara L., Hornung, Veit, Lebbink, Robert Jan, Duch, Mogens, Fitzgerald, Katherine A., Bahrami, Shervin, Mikkelsen, Jakob Giehm, Hartmann, Rune, Paludan, Søren R.

“…Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection…”
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Lambda Interferons: New Cytokines with Old Functions by Hamming, Ole J, Gad, Hans Henrik, Paludan, Søren, Hartmann, Rune

“…Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. Since their…”
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The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation by Ibsen, Mikkel Søes, Gad, Hans Henrik, Thavachelvam, Karthiga, Boesen, Thomas, Desprès, Philippe, Hartmann, Rune

“…The members of the oligoadenylate synthetase (OAS) family of proteins are antiviral restriction factors that target a wide range of RNA and DNA viruses. They…”
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Chikungunya Virus Envelope Protein E2 Provides a Vector for Targeted Antigen Delivery to Human Dermal CD14+ Dendritic Cells by Brulefert, Adrien, Kraemer, Melanie, Cumin, Marie, Selle, Amandine, Hoste, Astrid, Gad, Hans-Henrik, Rühl, Julia, Madinier, Jean-Baptiste, Chaloin, Olivier, Münz, Christian, Desprès, Philippe, Mueller, Christopher George, Flacher, Vincent

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Establishment of well-differentiated camelid airway cultures to study Middle East respiratory syndrome coronavirus by Gultom, Mitra, Kratzel, Annika, Portmann, Jasmine, Stalder, Hanspeter, Chanfon Bätzner, Astrid, Gantenbein, Hans, Gurtner, Corinne, Ebert, Nadine, Gad, Hans Henrik, Hartmann, Rune, Posthaus, Horst, Zanolari, Patrik, Pfaender, Stephanie, Thiel, Volker, Dijkman, Ronald

“…In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia and was mostly associated with severe respiratory illness in humans…”
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The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein by Bussey, Kendra A, Lau, Ulrike, Schumann, Sophie, Gallo, Antonio, Osbelt, Lisa, Stempel, Markus, Arnold, Christine, Wissing, Josef, Gad, Hans Henrik, Hartmann, Rune, Brune, Wolfram, Jänsch, Lothar, Whitehouse, Adrian, Brinkmann, Melanie M

“…Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few oncogenic human viruses known to date. Its large genome encodes more than 85 proteins and…”
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Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism by Ye, Liang, Schnepf, Daniel, Ohnemus, Annette, Ong, Li Ching, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter

“…Previous work showed that interferon-λ (IFN-λ) can trigger the synthesis of thymic stromal lymphopoietin (TSLP) by specialized epithelial cells in the upper…”
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The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry by Henrik Gad, Hans, Paulous, Sylvie, Belarbi, Essia, Diancourt, Laure, Drosten, Christian, Kümmerer, Beate M, Plate, Aileen E, Caro, Valérie, Desprès, Philippe

“…Abstract Human 2′,5′-oligoadenylate synthetase 3 (OAS3) exerts antiviral effect against alphaviruses including Chikungunya virus (CHIKV) by inhibiting viral…”
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Viral recognition and the antiviral interferon response by Dalskov, Louise, Gad, Hans Henrik, Hartmann, Rune

“…Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce…”
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Length dependent activation of OAS proteins by dsRNA by Wang, Yinbiao, Holleufer, Andreas, Gad, Hans Henrik, Hartmann, Rune

“…The oligoadenylate synthetase (OAS) family of enzymes are interferon-inducible antiviral proteins, which synthesize the secondary messenger 2′-5′-linked…”
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The Influence of the rs30461 Single Nucleotide Polymorphism on IFN-λ1 Activity and Secretion by Møhlenberg, Michelle, Gad, Hans Henrik, Hartmann, Rune

“…Genetic variation within the loci is associated with several diseases and evidence indicates that the genes have been subjects of strong selection during…”
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Two cGAS-like receptors induce antiviral immunity in Drosophila by Holleufer, Andreas, Winther, Kasper Grønbjerg, Gad, Hans Henrik, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Deng, Huimin, Liu, Jiyong, Frederiksen, Ninna Ahlmann, Simonsen, Bine, Andersen, Line Lykke, Kleigrewe, Karin, Dalskov, Louise, Pichlmair, Andreas, Cai, Hua, Imler, Jean-Luc, Hartmann, Rune

“…In mammals, cyclic GMP–AMP (cGAMP) synthase (cGAS) produces the cyclic dinucleotide 2′3′-cGAMP in response to cytosolic DNA and this triggers an antiviral…”
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Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin by Ye, Liang, Schnepf, Daniel, Becker, Jan, Ebert, Karolina, Tanriver, Yakup, Bernasconi, Valentina, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter

“…Interferon-λ (IFN-λ) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-λ in adaptive immunity is…”
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PD-L1 and PD-L2 immune checkpoint protein induction by type III interferon in non-small cell lung cancer cells by Larsen, Trine Vilsbøll, Daugaard, Tina Fuglsang, Gad, Hans Henrik, Hartmann, Rune, Nielsen, Anders Lade

“…•A type-III IFN-λ signalosome is present in NSCLC cells and tumors.•IFN- λ can mediate induction of PD-L1 and PD-L2 mRNA expression in NSCLC cells.•PD-L1 and…”
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Effective Interferon Lambda Treatment Regimen To Control Lethal MERS-CoV Infection in Mice by Dijkman, Ronald, Verma, Abhishek Kumar, Selvaraj, Muneeswaran, Ghimire, Roshan, Gad, Hans Henrik, Hartmann, Rune, More, Sunil, Perlman, Stanley, Thiel, Volker, Channappanavar, Rudragouda

“…Effective broad-spectrum antivirals are critical to prevent and control emerging human coronavirus (hCoV) infections. Despite considerable progress made toward…”
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