Search Results - "HENNE, Kirk R"

High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II by Wang, Junhua, Bhalla, Akhil, Ullman, Julie C, Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L, Skuja, Lukas L, Dugas, Jason C, Davis, Sonnet S, Poda, Suresh B, Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K, Henry, Anastasia G, Harris, Jeffrey M, Henne, Kirk R, Astarita, Giuseppe

“…We recently developed a blood-brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and…”
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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement by Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as an attractive therapeutic target for cardiovascular disease. Monoclonal antibodies (mAbs)…”
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Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome by Arguello, Annie, Meisner, René, Thomsen, Elliot R, Nguyen, Hoang N, Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M, Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C, Fang, Meng, Lopez, Isabel A, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R, Henry, Anastasia G, Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M, Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E

“…Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder caused by deficiency of the iduronate-2-sulfatase (IDS) enzyme, resulting in cellular…”
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Bioactivation of 4-Ipomeanol by CYP4B1:  Adduct Characterization and Evidence for an Enedial Intermediate by Baer, Brian R, Rettie, Allan E, Henne, Kirk R

“…4-Ipomeanol (IPO) is a pneumotoxin that is bioactivated to a reactive intermediate that binds to DNA and other cellular macromolecules. Despite over 30 years…”
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys by Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu

“…Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the…”
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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme by Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S

“…Delivery of biotherapeutics across the blood-brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin…”
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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease by Cushing, Timothy D., Hao, Xiaolin, Shin, Youngsook, Andrews, Kristin, Brown, Matthew, Cardozo, Mario, Chen, Yi, Duquette, Jason, Fisher, Ben, Gonzalez-Lopez de Turiso, Felix, He, Xiao, Henne, Kirk R., Hu, Yi-Ling, Hungate, Randall, Johnson, Michael G., Kelly, Ron C., Lucas, Brian, McCarter, John D., McGee, Lawrence R., Medina, Julio C., San Miguel, Tisha, Mohn, Deanna, Pattaropong, Vatee, Pettus, Liping H., Reichelt, Andreas, Rzasa, Robert M., Seganish, Jennifer, Tasker, Andrew S., Wahl, Robert C., Wannberg, Sharon, Whittington, Douglas A., Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Dawei, Metz, Daniela P.

“…The development and optimization of a series of quinolinylpurines as potent and selective PI3Kδ kinase inhibitors with excellent physicochemical properties are…”
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BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4 by KALGUTKAR, Amit S, VAZ, Alfin D. N, HOP, Cornelis E. C. A, LAME, Mary E, HENNE, Kirk R, SOGLIA, John, ZHAO, Sabrina X, ABRAMOV, Yuri A, LOMBARDO, Franco, COLLIN, Claire, HENDSCH, Zachary S

“…The therapeutic benefits of the antidepressant nefazodone have been hampered by several cases of acute hepatotoxicity/liver failure. Although the mechanism of…”
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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4 by Kalgutkar, Amit S., Henne, Kirk R., Lame, Mary E., Vaz, Alfin D.N., Collin, Claire, Soglia, John R., Zhao, Sabrina X., Hop, Cornelis E.C.A.

“…Therapy with the antidepressant trazodone has been associated with several cases of idiosyncratic hepatotoxicity. While the mechanism of hepatotoxicity remains…”
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A comprehensive listing of bioactivation pathways of organic functional groups by Kalgutkar, Amit S, Gardner, Iain, Obach, R Scott, Shaffer, Christopher L, Callegari, Ernesto, Henne, Kirk R, Mutlib, Abdul E, Dalvie, Deepak K, Lee, Jae S, Nakai, Yasuhiro, O'Donnell, John P, Boer, Jason, Harriman, Shawn P

“…The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a drug has been released can lead to a severe restriction in its…”
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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme by Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K

“…CYP3A4-mediated biotransformation of…”
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Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction by WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K

“…The 2-methyl substituted indole, 2MI [2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid] is a potent dual…”
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Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome by Arguello, Annie, Meisner, René, Thomsen, Elliot R., Nguyen, Hoang N., Ravi, Ritesh, Simms, Jeffrey, Lo, Iris, Speckart, Jessica, Holtzman, Julia, Gill, Thomas M., Chan, Darren, Cheng, Yuhsiang, Chiu, Chi-Lu, Dugas, Jason C., Fang, Meng, Lopez, Isabel A., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Zhu, Yuda, Bhalla, Akhil, Henne, Kirk R., Henry, Anastasia G., Delucchi, Anthony, Costanzo, Simona, Harris, Jeffrey M., Diaz, Dolores, Scearce-Levie, Kimberly, Sanchez, Pascal E.

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A comparison of substrate dynamics in human CYP2E1 and CYP2A6 by Harrelson, John P., Henne, Kirk R., Alonso, Darwin O.V., Nelson, Sidney D.

“…Considering the dynamic nature of CYPs, methods that reveal information about substrate and enzyme dynamics are necessary to generate predictive models. To…”
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Covalent Linkage of Prosthetic Heme to CYP4 Family P450 Enzymes by Henne, Kirk R, Kunze, Kent L, Zheng, Yi-Min, Christmas, Peter, Soberman, Roy J, Rettie, Allan E

“…An extensive body of research on the structural properties of cytochrome P450 enzymes has established that these proteins possess a b-type heme prosthetic…”
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Covalent Heme Binding to CYP4B1 via Glu310 and a Carbocation Porphyrin Intermediate by Zheng, Yi-Min, Baer, Brian R, Kneller, M. Byron, Henne, Kirk R, Kunze, Kent L, Rettie, Allan E

“…Recently we found that CYP4B1, and several other members of the CYP4 family of enzymes, are covalently linked to their prosthetic heme group through an ester…”
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Enzymatic Determinants of the Substrate Specificity of CYP2C9:  Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding by Haining, Robert L, Jones, Jeffrey P, Henne, Kirk R, Fisher, Michael B, Koop, Dennis R, Trager, William F, Rettie, Allan E

“…Previous modeling efforts have suggested that coumarin ligand binding to CYP2C9 is dictated by electrostatic and π-stacking interactions with complementary…”
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Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis by Zheng, Y.i-Min, Henne, Kirk R., Charmley, Patrick, Kim, Richard B., McCarver, D.Gail, Cabacungan, Erwin T., Hines, Ronald N., Rettie, Allan E.

“…CYP4B1 isoforms from rodents and other common laboratory animals are involved in the bioactivation of a range of protoxins, including 2-aminofluorene,…”
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic by Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert

“…GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we…”
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Active Site Characteristics of CYP4B1 Probed with Aromatic Ligands by Henne, Kirk R, Fisher, Michael B, Iyer, Krishna R, Lang, Dieter H, Trager, William F, Rettie, Allan E

“…The active site topography of rabbit CYP4B1 has been studied relative to CYP2B1 and CYP102 using a variety of aromatic probe substrates. Oxidation of the…”
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