Search Results - "HENN, Brenna M"

great human expansion by Henn, Brenna M, Cavalli-Sforza, L. L, Feldman, Marcus W

“…Genetic and paleoanthropological evidence is in accord that today’s human population is the result of a great demic (demographic and geographic) expansion that…”
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Localization of adaptive variants in human genomes using averaged one-dependence estimation by Sugden, Lauren Alpert, Atkinson, Elizabeth G., Fischer, Annie P., Rong, Stephen, Henn, Brenna M., Ramachandran, Sohini

“…Statistical methods for identifying adaptive mutations from population genetic data face several obstacles: assessing the significance of genomic outliers,…”
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Genomic ancestry of North Africans supports back-to-Africa migrations by Henn, Brenna M, Botigué, Laura R, Gravel, Simon, Wang, Wei, Brisbin, Abra, Byrnes, Jake K, Fadhlaoui-Zid, Karima, Zalloua, Pierre A, Moreno-Estrada, Andres, Bertranpetit, Jaume, Bustamante, Carlos D, Comas, David

“…North African populations are distinct from sub-Saharan Africans based on cultural, linguistic, and phenotypic attributes; however, the time and the extent of…”
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Distance from sub-Saharan Africa predicts mutational load in diverse human genomes by Henn, Brenna M., Botigué, Laura R., Peischl, Stephan, Dupanloup, Isabelle, Lipatov, Mikhail, Maples, Brian K., Martin, Alicia R., Musharoff, Shaila, Cann, Howard, Snyder, Michael P., Excoffier, Laurent, Kidd, Jeffrey M., Bustamante, Carlos D.

“…The Out-of-Africa (OOA) dispersal ∼50,000 y ago is characterized by a series of founder events as modern humans expanded into multiple continents. Population…”
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Rapid, global demographic expansions after the origins of agriculture by Gignoux, Christopher R, Henn, Brenna M, Mountain, Joanna L

“…The invention of agriculture is widely assumed to have driven recent human population growth. However, direct genetic evidence for population growth after…”
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Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans by McManus, Kimberly F, Taravella, Angela M, Henn, Brenna M, Bustamante, Carlos D, Sikora, Martin, Cornejo, Omar E

“…The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by…”
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Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries by Uren, Caitlin, Kim, Minju, Martin, Alicia R, Bobo, Dean, Gignoux, Christopher R, van Helden, Paul D, Möller, Marlo, Hoal, Eileen G, Henn, Brenna M

“…Recent genetic studies have established that the KhoeSan populations of southern Africa are distinct from all other African populations and have remained…”
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Gene flow from North Africa contributes to differential human genetic diversity in southern Europe by Botigué, Laura R., Henn, Brenna M., Gravel, Simon, Maples, Brian K., Gignoux, Christopher R., Corona, Erik, Atzmon, Gil, Burns, Edward, Ostrer, Harry, Flores, Carlos, Bertranpetit, Jaume, Comas, David, Bustamante, Carlos D.

“…Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the…”
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Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females by Poznik, G. David, Henn, Brenna M., Yee, Muh-Ching, Sliwerska, Elzbieta, Euskirchen, Ghia M., Lin, Alice A., Snyder, Michael, Quintana-Murci, Lluis, Kidd, Jeffrey M., Underhill, Peter A., Bustamante, Carlos D.

“…The Y chromosome and the mitochondrial genome have been used to estimate when the common patrilineal and matrilineal ancestors of humans lived. We sequenced…”
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The power of contemporary African DNA: Exploring models of human evolution and health in Africa by Moller, Mario, Hoal, Eileen, Henn, Brenna M

“…It is generally accepted that humans evolved in Africa, but several opposing conceptual models representing our origins have been proposed. We shed light on…”
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Cryptic distant relatives are common in both isolated and cosmopolitan genetic samples by Henn, Brenna M, Hon, Lawrence, Macpherson, J Michael, Eriksson, Nick, Saxonov, Serge, Pe'er, Itsik, Mountain, Joanna L

“…Although a few hundred single nucleotide polymorphisms (SNPs) suffice to infer close familial relationships, high density genome-wide SNP data make possible…”
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Hunter-gatherer genomic diversity suggests a southern African origin for modern humans by Henn, Brenna M, Gignoux, Christopher R, Jobin, Matthew, Granka, Julie M, Macpherson, J.M, Kidd, Jeffrey M, Rodríguez-Botigué, Laura, Ramachandran, Sohini, Hon, Lawrence, Brisbin, Abra, Lin, Alice A, Underhill, Peter A, Comas, David, Kidd, Kenneth K, Norman, Paul J, Parham, Peter, Bustamante, Carlos D, Mountain, Joanna L, Feldman, Marcus W

“…Africa is inferred to be the continent of origin for all modern human populations, but the details of human prehistory and evolution in Africa remain largely…”
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Admixed Populations Improve Power for Variant Discovery and Portability in Genome-Wide Association Studies by Lin, Meng, Park, Danny S., Zaitlen, Noah A., Henn, Brenna M., Gignoux, Christopher R.

“…Genome-wide association studies (GWAS) are primarily conducted in single-ancestry settings. The low transferability of results has limited our understanding of…”
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The recombination landscape of the Khoe-San likely represents the upper limits of recombination divergence in humans by van Eeden, Gerald, Uren, Caitlin, Pless, Evlyn, Mastoras, Mira, van der Spuy, Gian D, Tromp, Gerard, Henn, Brenna M, Möller, Marlo

“…Recombination maps are  important resources for epidemiological and evolutionary analyses; however, there are currently no recombination maps representing any…”
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Inferring archaic introgression from hominin genetic data by Gopalan, Shyamalika, Atkinson, Elizabeth G., Buck, Laura T., Weaver, Timothy D., Henn, Brenna M.

“…Questions surrounding the timing, extent, and evolutionary consequences of archaic admixture into human populations have a long history in evolutionary…”
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Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population by Hilton, Hugo G, Norman, Paul J, Nemat-Gorgani, Neda, Goyos, Ana, Hollenbach, Jill A, Henn, Brenna M, Gignoux, Christopher R, Guethlein, Lisbeth A, Parham, Peter

“…Modulating natural killer cell functions in human immunity and reproduction are diverse interactions between the killer cell immunoglobulin-like receptors…”
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Genetic differentiation at probe SNPs leads to spurious results in meQTL discovery by Meeks, Gillian L., Henn, Brenna M., Gopalan, Shyamalika

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Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe by Sikora, Martin, Carpenter, Meredith L, Moreno-Estrada, Andres, Henn, Brenna M, Underhill, Peter A, Sánchez-Quinto, Federico, Zara, Ilenia, Pitzalis, Maristella, Sidore, Carlo, Busonero, Fabio, Maschio, Andrea, Angius, Andrea, Jones, Chris, Mendoza-Revilla, Javier, Nekhrizov, Georgi, Dimitrova, Diana, Theodossiev, Nikola, Harkins, Timothy T, Keller, Andreas, Maixner, Frank, Zink, Albert, Abecasis, Goncalo, Sanna, Serena, Cucca, Francesco, Bustamante, Carlos D

“…Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights…”
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A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility by Uren, Caitlin, Henn, Brenna M, Franke, Andre, Wittig, Michael, van Helden, Paul D, Hoal, Eileen G, Möller, Marlo

“…Utilizing data from published tuberculosis (TB) genome-wide association studies (GWAS), we use a bioinformatics pipeline to detect all polymorphisms in linkage…”
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A panel of ancestry informative markers for the complex five-way admixed South African coloured population by Daya, Michelle, van der Merwe, Lize, Galal, Ushma, Möller, Marlo, Salie, Muneeb, Chimusa, Emile R, Galanter, Joshua M, van Helden, Paul D, Henn, Brenna M, Gignoux, Chris R, Hoal, Eileen

“…Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies,…”
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