Search Results - "HENG, Tracy S. P"

Mesenchymal stromal cell apoptosis is required for their therapeutic function by Pang, Swee Heng Milon, D’Rozario, Joshua, Mendonca, Senora, Bhuvan, Tejasvini, Payne, Natalie L., Zheng, Di, Hisana, Assifa, Wallis, Georgia, Barugahare, Adele, Powell, David, Rautela, Jai, Huntington, Nicholas D., Dewson, Grant, Huang, David C. S., Gray, Daniel H. D., Heng, Tracy S. P.

“…Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in preclinical models, but the lack of clarity around their mechanisms of…”
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Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells by Mathias, Louisa J, Khong, Sacha M L, Spyroglou, Lisa, Payne, Natalie L, Siatskas, Christopher, Thorburn, Alison N, Boyd, Richard L, Heng, Tracy S P

“…Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy…”
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Effects of Castration on Thymocyte Development in Two Different Models of Thymic Involution by Heng, Tracy S. P, Goldberg, Gabrielle L, Gray, Daniel H. D, Sutherland, Jayne S, Chidgey, Ann P, Boyd, Richard L

“…Age-associated thymic involution is accompanied by decreased thymic output. This adversely affects general immune competence and T cell recovery following…”
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Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice by Heng, Tracy S P, Reiseger, Jessica J, Fletcher, Anne L, Leggatt, Graham R, White, Olivia J, Vlahos, Katerina, Frazer, Ian H, Turner, Stephen J, Boyd, Richard L

“…Recent evidence suggests that the decline in resistance to viral infections with age occurs predominantly as a result of a gradual loss of naïve…”
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Biological Considerations in Scaling Up Therapeutic Cell Manufacturing by Cherian, Darshana S., Bhuvan, Tejasvini, Meagher, Laurence, Heng, Tracy S. P.

“…Cell therapeutics — using cells as living drugs — have made advances in many areas of medicine. One of the most clinically studied cell-based therapy products…”
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Secondary Lymphoid Organs in Mesenchymal Stromal Cell Therapy: More Than Just a Filter by Zheng, Di, Bhuvan, Tejasvini, Payne, Natalie L., Heng, Tracy S. P.

“…Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in inflammatory models of human disease. However, clinical translation has fallen…”
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Subcutaneous delivery of mesenchymal stromal cells induces immunoregulatory effects in the lymph node prior to their apoptosis by Zheng, Di, Bhuvan, Tejasvini, Payne, Natalie L, Pang, Swee H. M, Mendonca, Senora, Hutchinson, Mark R, McKinnirey, Flyn, Morgan, Charlotte, Vesey, Graham, Meagher, Laurence, Heng, Tracy S. P

“…Abstract Background Mesenchymal stromal cell (MSC) therapy commonly involves systemic infusion of MSCs, which undergo apoptosis in the lung and induce…”
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Getting back at nature: understanding thymic development and overcoming its atrophy by Heng, Tracy SP, Chidgey, Ann P, Boyd, Richard L

“…T cell development is a complex and tightly regulated process involving reciprocal interactions between the thymic stroma and differentiating thymocytes…”
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Stem cells—meet immunity by Heng, Tracy S. P., Dudakov, Jarrod A., Khong, Danika M. P., Chidgey, Ann P., Boyd, Richard L.

“…The ability of stem cells to differentiate into various different cell types holds great promise for the treatment of irreversible tissue damage that occurs in…”
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Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages by D'Rozario, Joshua, Knoblich, Konstantin, Lütge, Mechthild, Shibayama, Christian Pérez, Cheng, Hung-Wei, Alexandre, Yannick O, Roberts, David, Campos, Joana, Dutton, Emma E, Suliman, Muath, Denton, Alice E, Turley, Shannon J, Boyd, Richard L, Mueller, Scott N, Ludewig, Burkhard, Heng, Tracy S P, Fletcher, Anne L

“…The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche…”
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The Immunological Genome Project: networks of gene expression in immune cells by Heng, Tracy S P, Painter, Michio W, Elpek, Kutlu, Lukacs-Kornek, Veronika, Mauermann, Nora, Turley, Shannon J, Koller, Daphne, Kim, Francis S, Wagers, Amy J, Asinovski, Natasha, Davis, Scott, Fassett, Marlys, Feuerer, Markus, Gray, Daniel H D, Haxhinasto, Sokol, Hill, Jonathan A, Hyatt, Gordon, Laplace, Catherine, Leatherbee, Kristen, Mathis, Diane, Benoist, Christophe, Jianu, Radu, Laidlaw, David H, Best, J Adam, Knell, Jamie, Goldrath, Ananda W, Jarjoura, Jessica, Sun, Joseph C, Zhu, Yanan, Lanier, Lewis L, Ergun, Ayla, Li, Zheng, Collins, James J, Shinton, Susan A, Hardy, Richard R, Friedline, Randall, Sylvia, Katelyn, Kang, Joonsoo

“…The Immunological Genome Project combines immunology and computational biology laboratories in an effort to establish a complete 'road map' of gene-expression…”
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Lymph node stroma join the cancer support network by Fletcher, Anne L, Heng, Tracy S P

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Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis by Fletcher, Anne L, Elman, Jessica S, Astarita, Jillian, Murray, Ryan, Saeidi, Nima, D'Rozario, Joshua, Knoblich, Konstantin, Brown, Flavian D, Schildberg, Frank A, Nieves, Janice M, Heng, Tracy S P, Boyd, Richard L, Turley, Shannon J, Parekkadan, Biju

“…Sepsis is an aggressive inflammatory syndrome and a global health burden estimated to kill 7.3 million people annually. Single-target molecular therapies have…”
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Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells by Sheridan, Julie M., Keown, Ashleigh, Policheni, Antonia, Roesley, Siti N.A., Rivlin, Noa, Kadouri, Noam, Ritchie, Matthew E., Jain, Reema, Abramson, Jakub, Heng, Tracy S.P., Gray, Daniel H.D.

“…Evidence suggests that a stem-cell-driven differentiation hierarchy maintains the dynamic thymic epithelial cell (TEC) network that governs T lymphocyte…”
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Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice by Goldberg, Gabrielle L, Dudakov, Jarrod A, Reiseger, Jessica J, Seach, Natalie, Ueno, Tomoo, Vlahos, Katerina, Hammett, Maree V, Young, Lauren F, Heng, Tracy S P, Boyd, Richard L, Chidgey, Ann P

“…Cytotoxic antineoplastic therapy is used to treat malignant disease but results in long-term immunosuppression in postpubertal and adult individuals, leading…”
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De novo production of antigen-specific suppressor cells in vivo by Kretschmer, Karsten, Heng, Tracy S P, von Boehmer, Harald

“…Foxp3-expressing regulatory T cells (Treg) play an essential role in maintaining tolerance to self antigens and are generated under physiological conditions…”
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Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation by GOLDBERG, Gabrielle L, SUTHERLAND, Jayne S, HAMMET, Maree V, MILTON, Morag K, HENG, Tracy S. P, CHIDGEY, Ann P, BOYD, Richard L

“…Autologous hematopoietic stem cell transplantation (auto-HSCT) patients experience long-term immunosuppression, which increases susceptibility to infection and…”
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