Search Results - "HENDERSON, Marilyn C"

Flavin-containing monooxygenase-3: Induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver by Celius, Trine, Pansoy, Andrea, Matthews, Jason, Okey, Allan B., Henderson, Marilyn C., Krueger, Sharon K., Williams, David E.

“…Flavin-containing monooxygenases often are thought not to be inducible but we recently demonstrated aryl hydrocarbon receptor (AHR)-dependent induction of FMO…”
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Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants by Koukouritaki, Sevasti B, Poch, Mark T, Henderson, Marilyn C, Siddens, Lisbeth K, Krueger, Sharon K, VanDyke, Jonathan E, Williams, David E, Pajewski, Nicholas M, Wang, Tao, Hines, Ronald N

“…Flavin-containing monooxygenases (FMOs) are important for the disposition of many therapeutics, environmental toxicants, and nutrients. FMO3, the major adult…”
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Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms by Siddens, Lisbeth K., Henderson, Marilyn C., VanDyke, Jonathan E., Williams, David E., Krueger, Sharon K.

“…The significance of active versus inactive flavin-containing monooxygenase 2 (FMO2) for human drug and xenobiotic metabolism and sensitivity is unknown, but…”
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Mammalian flavin-containing monooxygenase (FMO) as a source of hydrogen peroxide by Siddens, Lisbeth K., Krueger, Sharon K., Henderson, Marilyn C., Williams, David E.

“…Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2…”
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Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K by Krueger, Sharon K, Henderson, Marilyn C, Siddens, Lisbeth K, VanDyke, Jonathan E, Benninghoff, Abby D, Karplus, P Andrew, Furnes, Bjarte, Schlenk, Daniel, Williams, David E

“…Catalytically active human flavin-containing monooxygenase isoform 2 (FMO2.1) is encoded by an allele detected only in individuals of African or Hispanic…”
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Prenylflavonoids from Hops Inhibit the Metabolic Activation of the Carcinogenic Heterocyclic Amine 2-Amino-3-methylimidazo[4,5-f]quinoline, Mediated by cDNA-Expressed Human CYP1A2 by MIRANDA, Cristobal L, YANG, Yea-Huey, HENDERSON, Marilyn C, STEVENS, Jan F, SANTANA-RIOS, Gilberto, DEINZER, Max L, BUHLER, Donald R

“…The heterocyclic amine 2-amino-3-methylimidazo[4,5- f ]quinoline (IQ) is a potential human carcinogen found in cooked food that requires initial metabolic…”
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Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry by Madeen, Erin P, Ognibene, Ted J, Corley, Richard A, McQuistan, Tammie J, Henderson, Marilyn C, Baird, William M, Bench, Graham, Turteltaub, Ken W, Williams, David E

“…Metabolism is a key health risk factor following exposures to pro-carcinogenic polycyclic aromatic hydrocarbons (PAHs) such as dibenzo­[def,p]­chrysene (DBC),…”
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C-terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility by Krueger, Sharon K., Siddens, Lisbeth K., Henderson, Marilyn C., VanDyke, Jonathan E., Karplus, P. Andrew, Pereira, Clifford B., Williams, David E.

“…Flavin-containing monooxygenases (FMO) are membrane-associated enzymes contributing to oxidative metabolism of drugs and other chemicals. There are no known…”
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Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones by Henderson, Marilyn C., Siddens, Lisbeth K., Krueger, Sharon K., Stevens, J. Fred, Kedzie, Karen, Fang, Wenkui K., Heidelbaugh, Todd, Nguyen, Phong, Chow, Ken, Garst, Michael, Gil, Daniel, Williams, David E.

“…Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and…”
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Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes by Henderson, Marilyn C., Siddens, Lisbeth K., Morré, Jeffrey T., Krueger, Sharon K., Williams, David E.

“…Tuberculosis (TB) results from infection with Mycobacterium tuberculosis and remains endemic throughout the world with one-third of the world's population…”
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Human Flavin-Containing Monooxygenase Form 2 S-Oxygenation:  Sulfenic Acid Formation from Thioureas and Oxidation of Glutathione by Henderson, Marilyn C, Krueger, Sharon K, Stevens, Jan F, Williams, David E

“…Thioureas are oxygenated by flavin-containing monooxygenases (FMOs), forming reactive sulfenic and/or sulfinic acids. Sulfenic acids can reversibly react with…”
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S-Oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2 by Henderson, Marilyn C, Krueger, Sharon K, Siddens, Lisbeth K, Stevens, Jan F, Williams, David E

“…Phorate and disulfoton are organophosphate insecticides containing three oxidizable sulfurs, including a thioether. Previous studies have shown that only the…”
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Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413Ks by KRUEGER, Sharon K, HENDERSON, Marilyn C, SIDDENS, Lisbeth K, VANDYKE, Jonathan E, BENNINGHOFF, Abby D, KARPLUS, P. Andrew, FURNES, Bjarte, SCHLENK, Daniel, WILLIAMS, David E

“…Catalytically active human flavin-containing monooxygenase isoform 2 (FMO2.1) is encoded by an allele detected only in individuals of African or Hispanic…”
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Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics by Krueger, Sharon K, Siddens, Lisbeth K, Henderson, Marilyn C, Andreasen, Eric A, Tanguay, Robert L, Pereira, Clifford B, Cabacungan, Erwin T, Hines, Ronald N, Ardlie, Kristin G, Williams, David E

“…OBJECTIVESPrevious work defined two flavin-containing monooxygenase 2 (FMO2) alleles. The major allele, FMO2*2 (g.23,238C>T), encodes truncated inactive…”
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Effects of 17β-Estradiol and Testosterone on Hepatic mRNA/Protein Levels and Catalytic Activities of CYP2M1, CYP2K1, and CYP3A27 in Rainbow Trout (Oncorhynchus mykiss) by Buhler, Donald R., Miranda, Cristobal L., Henderson, Marilyn C., Yang, Yea-Huey, Lee, Su-Jun, Wang-Buhler, Jun-Lan

“…There is growing concern that exposure to chemicals in the environment can disrupt the endocrine systems of wildlife and humans, causing reproductive problems…”
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Effect of xenoestrogen exposure on the expression of cytochrome P450 isoforms in rainbow trout liver by Katchamart, Sirinmas, Miranda, Cristobal L., Henderson, Marilyn C., Pereira, Clifford B., Buhler, Donald R.

“…We studied the estrogenic effects of model chemicals in one‐year‐old juvenile rainbow trout. Methoxychlor (20 mg/kg), diethylstilbestrol (15 mg/kg),…”
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Heterologous expression of CYP2K1 and identification of the expressed protein (BV-CYP2K1) as lauric acid (ω-1)-hydroxylase and aflatoxin B1 exo-epoxidase by YANG, Yea-Huey, MIRANDA, Cristobal L, HENDERSON, Marilyn C, WANG-BUHLER, Jun-Lan, BUHLER, Donald R

“…LMC2 is the most abundant constitutively expressed hepatic cytochrome P450 found in sexually immature rainbow trout (Onchorynchus mykiss) and is also the…”
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The regiospecific hydroxylation of lauric acid by rainbow trout (oncorhynchus mykiss) cytochrome P450s by BUHLER, D. R, MIRANDA, C. L, DEINZER, M. L, GRIFFIN, D. A, HENDERSON, M. C

“…We have reexamined the hydroxylation of [1- 14 C]-lauric acid by trout liver microsomes and reconstituted trout P450s using a new HPLC system that gave an…”
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Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons:In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry by Madeen, Erin P., Ognibene, Ted J., Corley, Richard A., McQuistan, Tammie J., Henderson, Marilyn C., Baird, William M., Bench, Graham, Turteltaub, Ken W., Williams, David E.

“…Metabolism is a key health risk factor following exposures to pro-carcinogenic polycyclic aromatic hydrocarbons (PAHs) such as dibenzo[def,p]chrysene (DBC), an…”
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Induction of lauric acid hydroxylase activity in catfish and bluegill by peroxisome proliferating agents by Haasch, Mary L, Henderson, Marilyn C, Buhler, Donald R

“…In mammals, sensitivity to peroxisome proliferation by peroxisome proliferating agents (PPAs) appears to be correlated with inducibility of lauric acid…”
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