Search Results - "HENDERSON, G. B"

An Iron-Carboxylate Bond Links the Heme Units of Malaria Pigment by Andrew F. G. Slater, Swiggard, William J., Orton, Brian R., Flitter, William D., Goldberg, Daniel E., Cerami, Anthony, Henderson, Graeme B.

“…The intraerythrocytic malaria parasite uses hemoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an…”
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Hemoglobin Degradation in the Malaria Parasite Plasmodium falciparum: An Ordered Process in a Unique Organelle by Goldberg, Daniel E., Andrew F. G. Slater, Cerami, Anthony, Henderson, Graeme B.

“…The malaria parasite Plasmodium falciparum uses host erythrocyte hemoglobin as a major nutrient source. We report the purification of P. falciparum digestive…”
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Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum : a catabolic pathway initiated by a specific aspartic protease by GOLDBERG, D. E, SLATER, A. F. G, BEAVIS, R, CHAIT, B, CERAMI, A, HENDERSON, G. B

“…Hemoglobin is an important nutrient source for intraerythrocytic malaria organisms. Its catabolism occurs in an acidic digestive vacuole. Our previous studies…”
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Trypanothione is the Primary Target for Arsenical Drugs against African Trypanosomes by Fairlamb, Alan H., Henderson, Graeme B., Cerami, Anthony

“…The trypanosomatid metabolite N1, N8-bis-(glutathionyl)spermidine (trypanothione) has been demonstrated to form a stable adduct with the aromatic arsenical…”
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Subversive'' Substrates for the Enzyme Trypanothione Disulfide Reductase: Alternative Approach to Chemotherapy of Chagas Disease by Henderson, Graeme B., Ulrich, Peter, Fairlamb, Alan H., Rosenberg, Ian, Pereira, Miercio, Sela, Michael, Cerami, Anthony

“…The trypanosomatid flavoprotein disulfide reductase, trypanothione reductase, is shown to catalyze one-electron reduction of suitably substituted…”
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X-Ray Structure of Trypanothione Reductase from Crithidia fasciculata at 2.4-Å Resolution by Kuriyan, John, Kong, Xiang-Peng, Krishna, T. S. R., Sweet, Robert M., Murgolo, Nicholas J., Field, Helen, Cerami, Anthony, Henderson, Graeme B.

“…Trypanosomes and related protozoan parasites lack glutathione reductase and possess instead a closely related enzyme that serves as the reductant of a…”
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Identification of efflux systems for large anions and anionic conjugates as the mediators of methotrexate efflux in L1210 cells by Saxena, Manju, Henderson, Gary B.

“…Two ATP-dependent efflux systems for methotrexate have been identified in inside-out vesicles from an L1210 mouse cell variant with a defective influx carrier…”
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Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump by HENDERSON, G. B, STRAUSS, B. P

“…C6 rat glioma cells were investigated for a shared unidirectional efflux system for cAMP and cholate. [3H]Cholate was accumulated (at pH 7.3) by scraped C6…”
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Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells by HENDERSON, G. B, STRAUSS, B. P

“…The growth requirements and transport characteristics of folate compounds in a methotrexate-resistant L1210/R81 cell line were compared with parental cells…”
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Engineering the Substrate Specificity of Glutathione Reductase Toward that of Trypanothione Reduction by Henderson, Graeme B., Murgolo, Nicholas J., Kuriyan, John, Osapay, Klara, Kominos, Dorothea, Berry, Alan, Scrutton, Nigel S., Hinchliffe, Nigel W., Perham, Richard N., Cerami, Anthony

“…Glutathione reductase (EC 1.6.4.2; CAS registry number 9001-48-3) and trypanothione reductase (CAS registry number 102210-35-5), which are related flavoprotein…”
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Functional implications from the effects of 1-chloro-2,4-dinitrobenzene and ethacrynic acid on efflux routes for methotrexate and cholate in L1210 cells by HENDERSON, G. B, HUGHES, T. R, SAXENA, M

“…1-Chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid were examined for the ability to inhibit unidirectional efflux routes in L1210 cells that extrude both…”
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The polarized emissivity of a wind-roughened sea surface: A Monte Carlo model by Henderson, Bradley G, Theiler, James, Villeneuve, Pierre

“…We use a Monte Carlo ray-tracing model to compute the thermal-infrared emissivity of a wind-roughened sea surface. The model includes the effects of both…”
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Detecting familial defective apolipoprotein B-100: three molecular scanning methods compared by Henderson, Bryony G, Wenham, Philip R, Ashby, J. Peter, Blundell, Gillian

“…Familial defective apolipoprotein (apo) B-100 (FDB), a condition that may give rise to hypercholesterolemia, is caused by mutations around codon 3500 of the…”
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Transport routes utilized by L1210 cells for the influx and efflux of methotrexate by Henderson, G B, Zevely, E M

“…Routes which contribute to the transport of methotrexate across the plasma membrane of L1210 cells have been evaluated. A single high affinity transport system…”
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Familial ligand-defective apolipoprotein B-100: detection, biochemical features and haplotype analysis of the R3531C mutation in the UK by Wenham, Philip R, Henderson, Bryony G, Penney, Michael D, Ashby, J.Peter, Rae, Peter W.H, Walker, Simon W

“…Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by…”
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Affinity labeling of the 5-methyltetrahydrofolate/methotrexate transport protein of L1210 cells by treatment with an N-hydroxysuccinimide ester of [3H]methotrexate by Henderson, G B, Zevely, E M

“…An N-hydroxysuccinimide ester of [3H]methotrexate has been employed to covalently label a specific binding protein that resides in the plasma membrane of L1210…”
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Effects of trypanothione on the biological activity of irradiated transforming DNA by Awad, S, Henderson, G B, Cerami, A, Held, K D

“…Held et al. (1984a,b) demonstrated previously that glutathione (GSH), a negatively charged thiol, is significantly less efficient in the hydrogen atom donation…”
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The effect of spatial resolution on satellite aerosol optical depth retrieval by Henderson, B.G., Chylek, P.

“…We use data from the Multispectral Thermal Imager (MTI) to evaluate the effects of spatial resolution on the accuracy of aerosol optical depth (AOD) retrieval…”
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Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata by Henderson, Graeme B, Fairlamb, Alan H, Ulrich, Peter, Cerami, Anthony

“…The substrate specificity of the trypanosomatid enzyme trypanothione reductase has been studied by measuring the ability of the enzyme to reduce a series of…”
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Purification and characterization of dihydroorotate dehydrogenase from the rodent malaria parasite Plasmodium berghei by Krungkrai, Jerapan, Cerami, Anthony, Henderson, Graeme B

“…Dihydroorotate dehydrogenase (DHODase) has been purified 400-fold from the rodent malaria parasite Plasmodium berghei to apparent homogeneity by Triton X-100…”
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