Search Results - "HEMPEL, Georg"

Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach by Kneller, Lisa Alina, Hempel, Georg

“…Purpose Dose-optimization strategies for risperidone are gaining in importance, especially in the elderly. Based on the genetic polymorphism of cytochrome P…”
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Development and Validation of a High-Performance Liquid Chromatography With Ultraviolet Detection Method to Facilitate Therapeutic Monitoring of Teicoplanin Using Dried Blood Spots by Ramadan, Ola, Opitz, Patrick, Hempel, Georg

“…In neonatal and pediatric intensive care units, Gram -positive infections are a significant cause of morbidity and mortality. The increase in infections caused…”
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Challenges at the Time of COVID-19: Opportunities and Innovations in Antivirals from Nature by Hensel, Andreas, Bauer, Rudolf, Heinrich, Michael, Spiegler, Verena, Kayser, Oliver, Hempel, Georg, Kraft, Karin

“…As viral infections are an increasing threat to human societies, the need for new therapeutic strategies is becoming even more obvious. As no vaccine is…”
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Identification of factors for a successful implementation of medication reviews in community pharmacies: Using Positive Deviance in pharmaceutical care by Waltering, Isabell, Schwalbe, Oliver, Hempel, Georg

“…Background Pharmacists in community pharmacies worldwide successfully conduct an increasing number of medication reviews (MR). Since June 2012 MR are…”
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Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function by Usman, Muhammad, Frey, Otto R., Hempel, Georg

“…Objectives The aim of this study was to evaluate different dosage regimens of meropenem in elderly patients in relation with renal function using a population…”
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Bioanalysis of doxorubicin aglycone metabolites in human plasma samples–implications for doxorubicin drug monitoring by Siebel, Christian, Lanvers-Kaminsky, Claudia, Würthwein, Gudrun, Hempel, Georg, Boos, Joachim

“…The widespread clinical use of the cytostatic doxorubicin together with the induction of chronic cardiomyopathy necessitates the conduct of further…”
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Antibody against poly(ethylene glycol) adversely affects PEG‐asparaginase therapy in acute lymphoblastic leukemia patients by Armstrong, Jonathan K., Hempel, Georg, Koling, Susanne, Chan, Linda S., Fisher, Timothy, Meiselman, Herbert J., Garratty, George

“…BACKGROUND. Rapid clearance of poly(ethylene glycol)‐asparaginase (PEG‐ASNase) has been reported for up to one‐third of patients treated for acute…”
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Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia by Khalil, Alaeddin, Würthwein, Gudrun, Golitsch, Jana, Hempel, Georg, Fobker, Manfred, Gerss, Joachim, Möricke, Anja, Zimmermann, Martin, Smisek, Petr, Zucchetti, Massimo, Nath, Christa, Attarbaschi, Andishe, Von Stackelberg, Arend, Gökbuget, Nicola, Rizzari, Carmelo, Conter, Valentino, Schrappe, Martin, Boos, Joachim, Lanvers-Kaminsky, Claudia

“…Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. We evaluated the prevalence of…”
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Developing a Method for Quantifying Meropenem in Children—Volumetric Adsorptive Microsampling Versus Plasma Sampling by Ramadan, Ola, Schatz, Lea Marie, van den Heuvel, Ingeborg, Masjosthusmann, Katja, Groll, Andreas H., Hempel, Georg

“…Meropenem is a carbapenem antibiotic often used in pediatric intensive care units due to its broad spectrum of activity. Therapeutic drug monitoring (TDM) is a…”
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Integration of physiological changes during the postpartum period into a PBPK framework and prediction of amoxicillin disposition before and shortly after delivery by Dallmann, André, Himstedt, Anneke, Solodenko, Juri, Ince, Ibrahim, Hempel, Georg, Eissing, Thomas

“…The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for amoxicillin for non-pregnant, pregnant and postpartum…”
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Development and validation of a bioanalytical method for the quantification of axitinib from plasma and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS by Opitz, Patrick, Zimmermann, Sebastian, Mc Laughlin, Anna M., Müller, Lothar, Fuxius, Stefan, Illerhaus, Gerald, Scherf-Clavel, Oliver, Kloft, Charlotte, Hempel, Georg

“…For therapeutic drug monitoring (TDM) of axitinib, the new volumetric absorption microsampling technology (VAMS™) was applied to obtain capillary blood samples…”
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Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2 by Mohamed, Fakry F, Anhlan, Darisuren, Schöfbänker, Michael, Schreiber, André, Classen, Nica, Hensel, Andreas, Hempel, Georg, Scholz, Wolfgang, Kühn, Joachim, Hrincius, Eike R, Ludwig, Stephan

“…For almost two years, the COVID-19 pandemic has constituted a major challenge to human health, particularly due to the lack of efficient antivirals to be used…”
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Pharmacokinetic characteristics and microbiologic appropriateness of cefazolin for perioperative antibiotic prophylaxis in elective cardiac surgery by Lanckohr, Christian, MD, Horn, Dagmar, Voeller, Swantje, PhD, Hempel, Georg, PhD, Fobker, Manfred, PhD, Welp, Henryk, MD, Koeck, Robin, MD, Ellger, Bjoern, MD

“…Abstract Objective Adequate levels of perioperative antibiotic prophylaxis are essential for prevention of surgical site infections. We examined…”
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Impact of training and structured medication review on medication appropriateness and patient-related outcomes in nursing homes: results from the interventional study InTherAKT by Mahlknecht, Angelika, Krisch, Laura, Nestler, Nadja, Bauer, Ulrike, Letz, Nina, Zenz, Daniel, Schuler, Jochen, Fährmann, Laura, Hempel, Georg, Flamm, Maria, Osterbrink, Jürgen

“…Uncoordinated interprofessional communication in nursing homes increases the risk of polypharmacy and inappropriate medication use. This may lead to augmented…”
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Decision support software-guided medication reviews in elderly patients with polypharmacy: a prospective analysis of routine data from community pharmacies (OPtiMed study protocol) by Maierhöfer, Stefan, Waltering, Isabell, Jacobs, Mareike, Würthwein, Gudrun, Appelrath, Meike, Koling, Susanne, Hempel, Georg

“…Pharmacist-led medication reviews are considered a valuable measure to address risks of polypharmacy. The software Medinspector is used in community pharmacies…”
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Improving medication appropriateness in nursing homes via structured interprofessional medication-review supported by health information technology: a non-randomized controlled study by Dellinger, Johanna Katharina, Pitzer, Stefan, Schaffler-Schaden, Dagmar, Schreier, Maria Magdalena, Fährmann, Laura Sandre, Hempel, Georg, Likar, Rudolf, Osterbrink, Jürgen, Flamm, Maria

“…In nursing home residents (NHRs), polypharmacy is widespread, accompanied by elevated risks of medication related complications. Managing medication in NHRs is…”
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Continuous infusion of physostigmine in patients with perioperative septic shock: A pharmacokinetic/pharmacodynamic study with population pharmacokinetic modeling by Pinder, Nadine, Zimmermann, Johannes B., Gastine, Silke, Würthwein, Gudrun, Hempel, Georg, Bruckner, Thomas, Hoppe-Tichy, Torsten, Weigand, Markus A., Swoboda, Stefanie

“…[Display omitted] •Little is known about physostigmine pharmacokinetics in critically ill patients.•An initial dose followed by continuous infusion resulted in…”
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Population Pharmacokinetics of Escalating Doses of Caspofungin in a Phase II Study of Patients with Invasive Aspergillosis by WÜRTHWEIN, Gudrun, CORNELY, Oliver A, GROLL, Andreas H, TRAME, Mirjam N, VEHRESCHILD, Janne J, VEHRESCHILD, Maria J. G. T, FAROWSKI, Fedja, MÜLLER, Carsten, BOOS, Joachim, HEMPEL, Georg, HALLEK, Michael

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy by Ahlmann, Martina, Hempel, Georg

“…Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As cyclophosphamide is in clinical use for more than 40 years, there is a…”
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Population Pharmacokinetics of Liposomal Amphotericin B and Caspofungin in Allogeneic Hematopoietic Stem Cell Recipients by WÜRTHWEIN, Gudrun, YOUNG, Charlotte, BOOS, Joachim, SILLING, Gerda, GROLL, Andreas H, LANVERS-KAMINSKY, Claudia, HEMPEL, Georg, TRAME, Mirjam N, SCHWERDTFEGER, Rainer, OSTERMANN, Helmut, HEINZ, Werner J, CORNELY, Oliver A, KOLVE, Hedwig

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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