Search Results - "HELTWEG, Birgit"

Substrate-specific Activation of Sirtuins by Resveratrol by Kaeberlein, Matt, McDonagh, Thomas, Heltweg, Birgit, Hixon, Jeffrey, Westman, Eric A., Caldwell, Seth D., Napper, Andrew, Curtis, Rory, DiStefano, Peter S., Fields, Stanley, Bedalov, Antonio, Kennedy, Brian K.

“…Resveratrol, a small molecule found in red wine, is reported to slow aging in simple eukaryotes and has been suggested as a potential calorie restriction…”
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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes by HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

“…SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of…”
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In vitro assays for the determination of histone deacetylase activity by Heltweg, Birgit, Trapp, Johannes, Jung, Manfred

“…Histone deacetylases are important regulators of transcription and an emerging target for anticancer drugs. We present an overview over various assay formats…”
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Nonisotopic substrate for assaying both human zinc and NAD +-dependent histone deacetylases by Heltweg, Birgit, Dequiedt, Franck, Verdin, Eric, Jung, Manfred

“…Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have…”
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Subtype Selective Substrates for Histone Deacetylases by Heltweg, Birgit, Dequiedt, Franck, Marshall, Brett L, Brauch, Carsten, Yoshida, Minoru, Nishino, Norikazu, Verdin, Eric, Jung, Manfred

“…To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure−reactivity relationships with…”
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A Microplate Reader-Based Nonisotopic Histone Deacetylase Activity Assay by Heltweg, Birgit, Jung, Manfred

“…Recent years have brought an enormous increase in knowledge concerning the involvement of histone deacetylase (HDAC) in gene regulation and the potential use…”
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A homogeneous nonisotopic histone deacetylase activity assay by Heltweg, Birgit, Jung, Manfred

“…Histone deacetylases (HDACs) are important regulators of transcription, and their inhibitors are a promising class of anticancer agents. The methods for the…”
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Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression by Skarpidi, Evangelia, Cao, Hua, Heltweg, Birgit, White, Brian F, Marhenke, Ronald L, Jung, Manfred, Stamatoyannopoulos, George

“…To examine whether hydroxamic acids are inducers of fetal hemoglobin expression, we tested the effects on γ gene expression of butyric and propionic hydroxamic…”
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Eosin Y as an Internal Standard for a Plate Reader-Based Quantitation of a Histone Deacetylase Substrate by Heltweg, Birgit, Jung, Manfred

“…Ongoing interest in histone deacetylase (HDAC) inhibitors as potential anticancer drugs and mechanistic tools for the study of gene regulation is driving the…”
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Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines by Wittich, Sybille, Scherf, Hans, Xie, Changping, Heltweg, Birgit, Dequiedt, Franck, Verdin, Eric, Gerhäuser, Clarissa, Jung, Manfred

“…Histone deacetylase (HDAC) inhibitors are a novel class of promising anti-cancer agents. Little information is available on the capacity of structurally…”
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Improvement and Validation of the Fluorescence-Based Histone Deacetylase Assay Using an Internal Standard by Hoffmann, Katharina, Heltweg, Birgit, Jung, Manfred

“…The determination of the activity of histone deacetylase (HDAC) and the potency of its inhibitors has become an important goal in medicinal chemistry. This is…”
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