Search Results - "HELM, B. A"

The structural basis of human IgE-Fc receptor interactions by SAYERS, I, HELM, B. A

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Peptide blocking of IgE/receptor interaction: possibilities and pitfalls by Helm, B. A., Spivey, A. C., Padlan, E. A.

“…The central role of IgE antibodies in immediate hypersensitivity responses has been extensively documented since their identification as the mediator of the…”
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A link between catalytic activity, IgE-independent mast cell activation, and allergenicity of bee venom phospholipase A2 by Dudler, T, Machado, DC, Kolbe, L, Annand, RR, Rhodes, N, Gelb, MH, Koelsch, K, Suter, M, Helm, BA

“…The molecular and cellular mechanisms controlling Ab isotype selection following encounter of a given Ag are still unclear, although the regulatory role of…”
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Protein mapping in rat basophilic leukaemia cells by Carroll, K.M., Carey, E.M., Helm, B.A.

“…This review discusses some of our recent studies on rat basophilic leukaemia (RBL) cells, a model cell line for mast cell function. Our interest in these cells…”
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Defective protein phosphorylation and Ca2+ mobilization in a low secreting variant of the rat basophilic leukemia cell line by BINGHAM, B. R, MONK, P. N, HELM, B. A

“…High and low secreting variants of the rat basophilic leukemia cell line represent powerful tools to study the molecular basis of stimulus/secretion coupling…”
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A monoclonal anti-IgE antibody against an epitope (amino acids 367-376) in the CH3 domain inhibits IgE binding to the low affinity IgE receptor (CD23) by Chretien, I, Helm, BA, Marsh, PJ, Padlan, EA, Wijdenes, J, Banchereau, J

“…We have produced three different mAb specific for human IgE-Fc. Their binding pattern to either heat-denatured IgE or a family of overlapping IgE-derived…”
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Modelling study of IgE/receptor interactions by Padlan, E A, Helm, B A

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Is there a link between the nature of agents that trigger mast cells and the induction of immunoglobulin (Ig)E synthesis? by Helm, B A

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Structure/function studies on IgE as a basis for the development of rational IgE antagonists by Helm, B A, Sayers, I, Padlan, E A, McKendrick, J E, Spivey, A C

“…Since the discovery of antibodies of the immunoglobulin (Ig)E isotype some 30 years ago, their pivotal role in mediating type I hypersensitivity responses has…”
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Potential allergens stimulate the release of mediators of the allergic response from cells of mast cell lineage in the absence of sensitization with antigen-specific IgE by Machado, D C, Horton, D, Harrop, R, Peachell, P T, Helm, B A

“…A number of structurally diverse antigens preferentially stimulate the synthesis of IgE antibodies, but no unifying principle has been proposed that explains…”
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Human IgE mediates stimulus secretion coupling in rat basophilic leukemia cells transfected with the alpha chain of the human high-affinity receptor by Wilson, A P, Pullar, C E, Camp, A M, Helm, B A

“…Cell surface expression of the alpha chain of the human (h) Fc epsilon receptor type 1 (Fc epsilon R1) can be observed following stable transfection of RBL-2H3…”
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The nature and importance of the inter-epsilon chain disulfide bonds in human IgE by Helm, B A, Ling, Y, Teale, C, Padlan, E A, Brüggemann, M

“…IgE antibodies are best known for their pathological role in allergy. The class-specific effector sites are located in the epsilon chains; these form covalent…”
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Commerce versus collaboration by Helm, B A, Padlan, E A

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Amino Acid Residues That Influence FcεRI-Mediated Effector Functions of Human Immunoglobulin E by Sayers, Ian, Cain, Stuart A, Swan, Jillian R. M, Pickett, Mark A, Watt, Peter J, Holgate, Stephen T, Padlan, Eduardo A, Schuck, Peter, Helm, Birgit A

“…Immunoglobulin E (IgE) mediates its effector functions via the Fc region of the molecule. IgE binding to and subsequent aggregation of the high-affinity…”
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Effect of monoclonal antihuman IgE on recombinant IgE(301-376) inhibition of specific IgE histamine release by Glovsky, M M, Kebo, D, Helm, B A, Horvath, S, Richards, J A, Chretien, I, Bencherau, J, Gould, H

“…To explore the binding domains of rCIgE(301-376) necessary for inhibition of passive transfer of rye grass and Chinese elm IgE to human basophils, we employed…”
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Identification of the High Affinity Receptor Binding Region in Human Immunoglobulin E (∗) by Helm, Birgit A., Sayers, Ian, Higginbottom, Adrian, Machado, Denise Cantarelli, Ling, Yan, Ahmad, Khalid, Padlan, Eduardo A., Wilson, A. Penelope M.

“…We have investigated the capacity of N- and C-terminally truncated and chimeric human (h) IgE-derived peptides to inhibit the binding of 125I-labeled hIgE, and…”
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Recombinant human IgE by Gould, H J, Helm, B A, Marsh, P J, Geha, R S

“…The gene for a human epsilon chain Fc fragment has been cloned and expressed at a high level in Escherichia coli, and its biological activity in binding to the…”
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Assessment of the Molecular Basis of the Proallergenic Effects of Cigarette Smoke by Smyth, Lucy J. C, Machado, Denise C, Upton, Anthony P, Good, Samantha, Aufderheide, Michaela, Helm, Birgit A

“…Epidemiological studies indicate a link between smoking and increased risk of immunoglobulin E-mediated allergies and asthma. The molecular basis underlying…”
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A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E by Padlan, E A, Helm, B A

“…The extracellular portion of the alpha-subunit of human high-affinity receptor for immunoglobulin-E (IgE), which contains two immunoglobulin (Ig) domains, was…”
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Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23) by Padlan, E A, Helm, B A

“…Models of the lectin-homology domains of the human and murine low-affinity receptors for IgE (Fc epsilon RII/CD23) were built on the basis of sequence…”
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