Search Results - "HELLMANN, N"

Lipid and phase specificity of α-toxin from S. aureus by Schwiering, M., Brack, A., Stork, R., Hellmann, N.

“…The pore forming toxin Hla (α-toxin) from Staphylococcus aureus is an important pathogenic factor of the bacterium S. aureus and also a model system for the…”
Get full text

Control of kinetics by cooperative interactions by Hellmann, N.

“…Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless,…”
Get full text

Natural Variation of Drug Susceptibility in Wild-Type Human Immunodeficiency Virus Type 1 by Parkin, N T, Hellmann, N S, Whitcomb, J M, Kiss, L, Chappey, C, Petropoulos, C J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors by Hecht, Frederick M, Grant, Robert M, Petropoulos, Christos J, Dillon, Beth, Chesney, Margaret A, Tian, Huan, Hellmann, Nicholas S, Bandrapalli, Nirmala I, Digilio, Laura, Branson, Bernard, Kahn, James O

“…Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow…”
Get full text

Antiretroviral Resistance during Successful Therapy of HIV Type 1 Infection by Martinez-Picado, J., DePasquale, M. P., Kartsonis, N., Hanna, G. J., Wong, J., Finzi, D., Rosenberg, E., Gunthard, H. F., Sutton, L., Savara, A., Petropoulos, C. J., Hellmann, N., Walker, B. D., Richman, D. D., Siliciano, R., D'Aquila, R. T.

“…HIV type 1 (HIV-1) drug resistance mutations were selected during antiretroviral therapy successfully suppressing plasma HIV-1 RNA to <50 copies/ml. New…”
Get full text

Drug Susceptibility in HIV Infection After Viral Rebound in Patients Receiving Indinavir-Containing Regimens by Havlir, Diane V, Hellmann, Nick S, Petropoulos, Christos J, Whitcomb, Jeannette M, Collier, Ann C, Hirsch, Martin S, Tebas, Pablo, Sommadossi, Jean-Pierre, Richman, Douglas D

“…CONTEXT Loss of viral suppression in patients infected with human immunodeficiency virus (HIV), who are receiving potent antiretroviral therapy, has been…”
Get full text

Reduced Antiretroviral Drug Susceptibility Among Patients With Primary HIV Infection by Little, Susan J, Daar, Eric S, D'Aquila, Richard T, Keiser, Philip H, Connick, Elizabeth, Whitcomb, Jeannette M, Hellmann, Nicholas S, Petropoulos, Christos J, Sutton, Lorraine, Pitt, Jacqui A, Rosenberg, Eric S, Koup, Richard A, Walker, Bruce D, Richman, Douglas D

“…CONTEXT The transmission of drug-resistant human immunodeficiency virus (HIV) has been documented, but the prevalence of such transmission is unknown…”
Get full text

Unusual oxygen binding behavior of a 24-meric crustacean hemocyanin by Hellmann, N., Paoli, M., Giomi, F., Beltramini, M.

“…Hemocyanins from Crustacea usually are found as 1 × 6 or 2 × 6-meric assemblies. An exception is the hemocyanin isolated from thalassinidean shrimps where the…”
Get full text

Progressive Reversion of Human Immunodeficiency Virus Type 1 Resistance Mutations In Vivo after Transmission of a Multiply Drug-Resistant Virus by Gandhi, Rajesh T., Wurcel, Alysse, Rosenberg, Eric S., Johnston, Mary N., Hellmann, Nicholas, Bates, Michael, Hirsch, Martin S., Walker, Bruce D.

“…Evolution and transmission of multiply drug-resistant human immunodeficiency virus type 1 (HIV-1) may limit therapeutic options as global treatment efforts…”
Get full text

Clinical and laboratory guidelines for the use of HIV-1 drug resistance testing as part of treatment management : recommendations for the European setting

“…Viral drug susceptibility is associated with virologic response to new treatments. Standardized drug resistance tests are now available, and data from some…”
Get full text

Novel Four-Drug Salvage Treatment Regimens after Failure of a Human Immunodeficiency Virus Type 1 Protease Inhibitor-Containing Regimen: Antiviral Activity and Correlation of Baseline Phenotypic Drug Susceptibility with Virologic Outcome by Deeks, Steven G., Hellmann, Nicholas S., Grant, Robert M., Parkin, Neil T., Petropoulos, Christos J., Becker, Mark, Symonds, William, Chesney, Margaret, Volberding, Paul A.

“…Twenty human immunodeficiency virus—infected patients experiencing virologic failure of an indinavir- or ritonavir-containing treatment regimen were evaluated…”
Get full text

Time Trends in Primary HIV-1 Drug Resistance Among Recently Infected Persons by Grant, Robert M, Hecht, Frederick M, Warmerdam, Maria, Liu, Lea, Liegler, Teri, Petropoulos, Christos J, Hellmann, Nicholas S, Chesney, Margaret, Busch, Michael P, Kahn, James O

“…CONTEXT Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy. OBJECTIVE…”
Get full text

Updated European recommendations for the clinical use of HIV drug resistance testing by VANDAMME, A.-M, SÖNNERBORG, A, CLEVENBERGH, P, CLUMECK, N, DEDES, N, DE LUCA, A, DOERR, H. W, FAUDON, J.-L, GATTI, G, GERSTOFT, J, HALL, W. W, HATZAKIS, A, AIT-KHALED, M, HELLMANN, N, HORBAN, A, LUNDGREN, J. D, KEMPF, D, MILLER, M, MILLER, V, MYERS, T. W, NIELSEN, C, OPRAVIL, M, PALMISANO, L, ALBERT, J, PERNO, C. F, PHILLIPS, A, PILLAY, D, PUMAROLA, T, RUIZ, L, SALMINEN, M, SCHAPIRO, J, SCHMIDT, B, SCHMIT, J.-C, SCHUURMAN, R, ASJO, B, SHULSE, E, SORIANO, V, STASZEWSKI, S, VELLA, S, YOULE, M, ZIERMANN, R, PERRIN, L, BACHELER, L, BANHEGYI, D, BOUCHER, C, BRUN-VEZINET, F, CAMACHO, R

“…In most European countries, HIV drug resistance testing has become a routine clinical tool. However, its practical implementation in a clinical context is…”
Get full text

Virologic and Immunologic Consequences of Discontinuing Combination Antiretroviral-Drug Therapy in HIV-Infected Patients with Detectable Viremia by Deeks, Steven G, Wrin, Terri, Liegler, Teri, Hoh, Rebecca, Hayden, Matthew, Barbour, Jason D, Hellmann, Nicholas S, Petropoulos, Christos J, McCune, Joseph M, Hellerstein, Marc K, Grant, Robert M

“…The goal of antiretroviral-drug therapy in patients with human immunodeficiency virus (HIV) infection is the complete suppression of viral replication. 1 , 2…”
Get full text

Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults by DEEKS, S. G, BARDITCH-CROVO, P, LIETMAN, P. S, HWANG, F, CUNDY, K. C, ROONEY, J. F, HELLMANN, N. S, SAFRIN, S, KAHN, J. O

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Broad Nucleoside Reverse-Transcriptase Inhibitor Cross-Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates by Whitcomb, Jeannette M., Parkin, Neil T., Chappey, Colombe, Hellmann, Nicholas S., Petropoulos, Christos J.

“…Nucleoside reverse-transcriptase inhibitors (NRTIs) are important components of most antiretroviral combination treatment regimens. Using a large collection of…”
Get full text

Cerebrospinal fluid response to structured treatment interruption after virological failure by PRICE, Richard W, PAXINOS, Ellen E, GRANT, Robert M, DREWS, Birgit, NILSSON, Annelie, HOH, Rebecca, HELLMANN, Nicholas S, PETROPOULOS, Christos J, DEEKS, Steven G

“…Structured antiretroviral treatment interruption (STI) has been advocated as a therapeutic strategy for HIV-1 infection. We report initial observations of…”
Get full text

Prevalence of Mutations Associated with Reduced Antiretroviral Drug Susceptibility among Human Immunodeficiency Virus Type 1 Seroconverters in the United States, 1993–1998 by Weinstock, Hillard, Respess, Richard, Heneine, Walid, Petropoulos, Christos J., Hellmann, Nicholas S., Luo, Chi-Cheng, Pau, Chou-Pong, Woods, Toni, Gwinn, Marta, Kaplan, Jonathan

“…To assess the prevalence of mutations associated with decreased antiretroviral drug susceptibility, specimens were tested from persons infected with human…”
Get full text

Transmission Fitness of Drug-Resistant Human Immunodeficiency Virus and the Prevalence of Resistance in the Antiretroviral-Treated Population by Leigh Brown, Andrew J, Frost, Simon D. W, Mathews, W. Christopher, Dawson, Keith, Hellmann, Nicholas S, Daar, Eric S, Richman, Douglas D, Little, Susan J

“…Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their…”
Get full text

Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites by Brown, A J, Precious, H M, Whitcomb, J M, Wong, J K, Quigg, M, Huang, W, Daar, E S, D'Aquila, R T, Keiser, P H, Connick, E, Hellmann, N S, Petropoulos, C J, Richman, D D, Little, S J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text