Search Results - "HELLER, R. Scott"

The islet ghrelin cell by Wierup, Nils, Sundler, Frank, Heller, R Scott

“…The islets of Langerhans are key regulators of glucose homeostasis and have been known as a structure for almost one and a half centuries. During the twentieth…”
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Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas by Tornehave, Ditte, Kristensen, Peter, Romer, John, Knudsen, Lotte Bjerre, Heller, R. Scott

“…We studied the intra-islet localization of the glucagon-like peptide 1 receptor (GLP-1R) by colocalization studies of the GLP-1R mRNA and protein with islet…”
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Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines by Hansen, Jakob Bondo, Tonnesen, Morten Fog, Madsen, Andreas Nygaard, Hagedorn, Peter H., Friberg, Josefine, Grunnet, Lars Groth, Heller, R. Scott, Nielsen, Anja Østergren, Størling, Joachim, Baeyens, Luc, Anker-Kitai, Leeat, Qvortrup, Klaus, Bouwens, Luc, Efrat, Shimon, Aalund, Mogens, Andrews, Nancy C., Billestrup, Nils, Karlsen, Allan E., Holst, Birgitte, Pociot, Flemming, Mandrup-Poulsen, Thomas

“…Reactive oxygen species (ROS) contribute to target-cell damage in inflammatory and iron-overload diseases. Little is known about iron transport regulation…”
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Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas by Suissa, Yaron, Magenheim, Judith, Stolovich-Rain, Miri, Hija, Ayat, Collombat, Patrick, Mansouri, Ahmed, Sussel, Lori, Sosa-Pineda, Beatriz, McCracken, Kyle, Wells, James M, Heller, R Scott, Dor, Yuval, Glaser, Benjamin

“…Neurogenin3(+) (Ngn3(+)) progenitor cells in the developing pancreas give rise to five endocrine cell types secreting insulin, glucagon, somatostatin,…”
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Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster by Hargreaves, Adam D., Zhou, Long, Christensen, Josef, Marlétaz, Ferdinand, Liu, Shiping, Li, Fang, Jansen, Peter Gildsig, Spiga, Enrico, Hansen, Matilde Thye, Pedersen, Signe Vendelbo Horn, Biswas, Shameek, Serikawa, Kyle, Fox, Brian A., Taylor, William R., Mulley, John Frederick, Zhang, Guojie, Heller, R. Scott, Holland, Peter W. H.

“…The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high…”
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Artifactual Insulin Release From Differentiated Embryonic Stem Cells by HANSSON, Mattias, TONNING, Anna, MELTON, Douglas, SEMB, Henrik, SERUP, Palle, FRANDSEN, Ulrik, PETRI, Andreas, RAJAGOPAL, Jayaraj, ENGLUND, Mikael C. O, HELLER, R. Scott, HAKANSSON, Joakim, FLECKNER, Jan, SKÖLD, Helen Nilsson

“…Artifactual Insulin Release From Differentiated Embryonic Stem Cells Mattias Hansson 1 , Anna Tonning 2 , Ulrik Frandsen 1 , Andreas Petri 1 3 , Jayaraj…”
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GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody by Pyke, Charles, Heller, R. Scott, Kirk, Rikke K, Ørskov, Cathrine, Reedtz-Runge, Steffen, Kaastrup, Peter, Hvelplund, Anders, Bardram, Linda, Calatayud, Dan, Knudsen, Lotte Bjerre

“…Glucagon-like peptide 1 (GLP-1) analogs are increasingly being used in the treatment of type 2 diabetes. It is clear that these drugs lower blood glucose…”
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The role of Brn4/ Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity by Scott Heller, R, Stoffers, Doris A, Liu, Aihua, Schedl, Andreas, Crenshaw, E.Bryan, Madsen, Ole D, Serup, Palle

“…Brain 4 (Brn4/ Pou3f4) and Pax6 are POU-homeodomain and paired-homeodomain transcription factors, respectively, that are expressed in the brain and the…”
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Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation by Heller, R. Scott, Dichmann, Darwin S., Jensen, Jan, Miller, Chris, Wong, Gordon, Madsen, Ole D., Serup, Palle

“…It is well established that gut and pancreas development depend on epithelial‐mesenchymal interactions. We show here that several Wnt, Frizzled, and secreted…”
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Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas by Klein, Tino, Ling, Zhidong, Heimberg, Harry, Madsen, Ole D, Heller, R. Scott, Serup, Palle

“…In this study we examined the expression of nestin in islets, the exocrine part, and the big ducts of the adult human pancreas by immunofluorescent double…”
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The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice by Petri, Andreas, Ahnfelt-Rønne, Jonas, Frederiksen, Klaus Stensgaard, Edwards, David George, Madsen, Dennis, Serup, Palle, Fleckner, Jan, Heller, R Scott

“…To understand the molecular mechanisms regulating pancreatic endocrine development and function, pancreatic gene expression was compared between Ngn3-deficient…”
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Immunohistochemistry of Pancreatic Development in Cattle and Pig by Carlsson, G.L, Scott Heller, R, Serup, P, Hyttel, P

“…With 8 figures and 2 tables The aim of this study was to characterize bovine and porcine pancreatic development by immunohistochemistry. In the pig, staining…”
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Short-term effects of INGAP and Reg family peptides on the appearance of small β-cells clusters in non-diabetic mice by Kapur, Rahul, Højfeldt, Tine Westergaard, Rønn, Sif Groth, Karlsen, Allan E., Heller, R. Scott

“…The Reg3 peptides INGAP-PP and human Reg3α/β (HIP) have been hypothesized to stimulate β-cell neogenesis in the pancreas. Administration of INGAP-PP has been…”
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GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation by Bang-Berthelsen, Claus H, Holm, Thomas L, Pyke, Charles, Simonsen, Lotte, Søkilde, Rolf, Pociot, Flemming, Heller, R Scott, Folkersen, Lasse, Kvist, Peter H, Jackerott, Malene, Fleckner, Jan, Vilién, Mogens, Knudsen, Lotte B, Heding, Anders, Frederiksen, Klaus S

“…Beneficial roles for glucagon-like peptide 1 (GLP-1)/GLP-1R signaling have recently been described in diseases, where low-grade inflammation is a common…”
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Intracranial ectopic pancreatic tissue by Heller, R. Scott, Tsugu, Hitoshi, Nabeshima, Kazuki, Madsen, Ole D.

“…A young Japanese female was in 2007 reported to suffer from a congenital brain malformation with a non-functioning pancreatic endocrine tumor arising from…”
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An immunohistochemical study of the endocrine pancreas of the African ice rat, Otomys sloggetti robertsi by Gustavsen, Carsten R., Pillay, Neville, Heller, R. Scott

“…The African ice rat, Otomys sloggetti robertsi, is a member of the subfamily Otomyinae, in the superfamily of Muroidea, to which all rodents belong. Very…”
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Acomys, the closest relatives to Gerbils, do express Pdx-1 protein and have similar islet morphology to Gerbils by Gustavsen, Carsten R., Kvicerova, Jana, Dickinson, Hayley, Heller, R. Scott

“…Acomys, also called spiny mice, were once used as a diabetes model. We have recently demonstrated that the closest relatives to the Acomys, members of the…”
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Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function by Mulley, John F, Hargreaves, Adam D, Hegarty, Matthew J, Heller, R Scott, Swain, Martin T

“…Understanding the evolution of the vertebrate pancreas is key to understanding its functions. The chondrichthyes (cartilaginous fish such as sharks and rays)…”
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Control of endodermal endocrine development by Hes-1 by Pedersen, Erna Engholm, Hald, Jacob, Serup, Palle, Galante, Philip, Jensen, Jan, Guillemot, Francois, Kageyama, Ryoichiro, Madsen, Ole D, Heller, R. Scott, Ishibashi, Makoto

“…Development of endocrine cells in the endoderm involves Atonal and Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as…”
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Genetic determinants of pancreatic ε-cell development by Heller, R. Scott, Jenny, Marjorie, Collombat, Patrick, Mansouri, Ahmed, Tomasetto, Catherine, Madsen, Ole D., Mellitzer, Georg, Gradwohl, Gerard, Serup, Palle

“…Recently, the expression of the peptide hormone ghrelin was detected in α-cells of the islets of Langerhans as well as in ε-cells, a newly discovered endocrine…”
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