Search Results - "HELL, Johannes"

CaMKII: claiming center stage in postsynaptic function and organization by Hell, Johannes W

“…While CaMKII has long been known to be essential for synaptic plasticity and learning, recent work points to new dimensions of CaMKII function in the nervous…”
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory by Yasuda, Ryohei, Hayashi, Yasunori, Hell, Johannes W.

“…Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity,…”
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How autoimmune antibodies kindle a firestorm in the brain by Hell, Johannes W

“…Autoimmune responses against NMDA receptors (NMDAR) and GABA A receptors (GABA A R) can cause encephalitis, which has been described as feeling like one’s…”
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Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation by Hell, Johannes W

“…Learning and the underlying long-lasting increases in glutamatergic synapse strength [called long-term potentiation (LTP)] require both Ca influx through…”
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Distinct Eligibility Traces for LTP and LTD in Cortical Synapses by He, Kaiwen, Huertas, Marco, Hong, Su Z., Tie, XiaoXiu, Hell, Johannes W., Shouval, Harel, Kirkwood, Alfredo

“…In reward-based learning, synaptic modifications depend on a brief stimulus and a temporally delayed reward, which poses the question of how synaptic activity…”
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How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD by Hell, Johannes W

“…Both synaptic long-term potentiation (LTP) and long-term depression (LTD) are thought to be critical for memory formation. Dell'Acqua and co-workers now…”
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The genetics of PKMζ and memory maintenance by Sacktor, Todd Charlton, Hell, Johannes W

“…Elucidating the molecular mechanisms that maintain long-term memory is a fundamental goal of neuroscience. Accumulating evidence suggests that persistent…”
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William Albert Catterall (1946–2024) by Hell, Johannes W., Herlitze, Stefan, Isom, Lori, Lee, Amy, Yarov-Yarovoy, Vladimir

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Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels by Dai, Shuiping, Hall, Duane D, Hell, Johannes W

“…Department of Pharmacology, University of Iowa, Iowa City, Iowa This review addresses the localized regulation of voltage-gated ion channels by…”
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Upper airway resistance during use of a laryngeal mask airway is flow-dependent and dominated by the laryngeal resistance by Hell, Johannes, Schmutz, Axel, Schumann, Stefan

“…During use of a laryngeal mask airway, resistance of the device and larynx contribute to the upper airway resistance. Detailed understanding of this combined…”
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Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome by Hamilton, Andrew M., Oh, Won Chan, Vega-Ramirez, Hugo, Stein, Ivar S., Hell, Johannes W., Patrick, Gentry N., Zito, Karen

“…Growth of new dendritic spines contributes to experience-dependent circuit plasticity in the cerebral cortex. Yet the signaling mechanisms leading to new spine…”
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CaMKII: a central molecular organizer of synaptic plasticity, learning and memory by Yasuda, Ryohei, Hayashi, Yasunori, Hell, Johannes W.

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Role of Palmitoylation of Postsynaptic Proteins in Promoting Synaptic Plasticity by Matt, Lucas, Kim, Karam, Chowdhury, Dhrubajyoti, Hell, Johannes W

“…Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty acid palmitate to cysteine residues, which influences trafficking,…”
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How CBP/Shank3 Guards Rap and H-Ras by Chowdhury, Dhrubajyoti, Hell, Johannes W

“…In this issue of Structure, Cai et al. (2020) describe crystal structures of the postsynaptic protein Shank3, a homolog of cortactin binding protein 1 (CBP1),…”
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BRAG about (s)lots by Brown, Joshua C, Hell, Johannes W, Gerges, Nashaat Z

“…Mutations in IQSEC2/BRAG1 cause intellectual dysfunction by impairing ARF-GEF activity and long-term depression. In this issue, Bai et al…”
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The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength by Barcomb, Kelsey, Hell, Johannes W., Benke, Tim A., Bayer, K. Ulrich

“…Learning, memory, and cognition are thought to require normal long-term potentiation (LTP) of synaptic strength, which in turn requires binding of the…”
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The Therapeutic Landscape of Rheumatoid Arthritis: Current State and Future Directions by Shams, Shahin, Martinez, Joseph M, Dawson, John R D, Flores, Juan, Gabriel, Marina, Garcia, Gustavo, Guevara, Amanda, Murray, Kaitlin, Pacifici, Noah, Vargas, Maxemiliano V, Voelker, Taylor, Hell, Johannes W, Ashouri, Judith F

“…Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted…”
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Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains by Zhang, Lei, Zhang, Peng, Wang, Guangfu, Zhang, Huaye, Zhang, Yajun, Yu, Yilin, Zhang, Mingxu, Xiao, Jian, Crespo, Piero, Hell, Johannes W., Lin, Li, Huganir, Richard L., Zhu, J. Julius

“…How signaling molecules achieve signal diversity and specificity is a long-standing cell biology question. Here we report the development of a targeted…”
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Mechanisms of postsynaptic localization of AMPA-type glutamate receptors and their regulation during long-term potentiation by Buonarati, Olivia R, Hammes, Erik A, Watson, Jake F, Greger, Ingo H, Hell, Johannes W

“…l-Glutamate is the main excitatory neurotransmitter in the brain, with postsynaptic responses to its release predominantly mediated by AMPA-type glutamate…”
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Stimulating β-adrenergic receptors promotes synaptic potentiation by switching CaMKII movement from LTD to LTP mode by Larsen, Matthew E., Buonarati, Olivia R., Qian, Hai, Hell, Johannes W., Bayer, K. Ulrich

“…Learning, memory, and cognition are thought to require synaptic plasticity, specifically including hippocampal long-term potentiation and depression (LTP and…”
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