Search Results - "HELENA GARCIA, M"

Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand by Côrte-Real, Leonor, Karas, Brittany, Gírio, Patrícia, Moreno, Alexis, Avecilla, Fernando, Marques, Fernanda, Buckley, Brian T., Cooper, Keith R., Doherty, Cathleen, Falson, Pierre, Garcia, M. Helena, Valente, Andreia

“…Two new ruthenium complexes, [Ru(η5-Cp)(PPh3)(2,2’-bipy-4,4’-R)]+ with R = -CH2OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both…”
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A new family of iron(II)-cyclopentadienyl compounds shows strong activity against colorectal and triple negative breast cancer cells by Pilon, Adhan, Brás, Ana Rita, Côrte-Real, Leonor, Avecilla, Fernando, Costa, Paulo J., Preto, Ana, Garcia, M. Helena, Valente, Andreia

“…The following is available online, Figure S1—1H NMR spectrum of complexes 6, in acetone-d6, Table S1. Bond lengths [Å] and angles [°] for…”
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Ruthenium–Cyclopentadienyl Bipyridine–Biotin Based Compounds: Synthesis and Biological Effect by Côrte-Real, Leonor, Karas, Brittany, Brás, Ana Rita, Pilon, Adhan, Avecilla, Fernando, Marques, Fernanda, Preto, Ana, Buckley, Brian T, Cooper, Keith R, Doherty, Cathleen, Garcia, M. Helena, Valente, Andreia

“…Prospective anticancer metallodrugs should consider target-specific components in their design in order to overcome the limitations of the current…”
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Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods by Santos, Filipa C., Costa, Paulo J., Garcia, M. Helena, Morais, Tânia S.

“…The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η 5 -C 5 H 5 ) derived complexes, that have already shown…”
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Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs by Moreira, Tiago, Francisco, Rita, Comsa, Elisabeta, Duban-Deweer, Sophie, Labas, Valérie, Teixeira-Gomes, Ana-Paula, Combes-Soia, Lucie, Marques, Fernanda, Matos, António, Favrelle, Audrey, Rousseau, Cyril, Zinck, Philippe, Falson, Pierre, Garcia, M. Helena, Preto, Ana, Valente, Andreia

“…In this work, we aimed to understand the biological activity and the mechanism of action of three polymer-‘ruthenium-cyclopentadienyl’ conjugates (RuPMC) and a…”
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In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model by Mendes, Nuno, Tortosa, Francisco, Valente, Andreia, Marques, Fernanda, Matos, António, Morais, Tânia S, Tomaz, Ana Isabel, Gärtner, Fátima, Garcia, M Helena

“…Ruthenium-based anti-cancer compounds are proposed as viable alternatives that might circumvent the disadvantages of platinum-based drugs, the only…”
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New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity by Lopes, João, Alves, David, Morais, Tânia S., Costa, Paulo J., Piedade, M. Fátima M., Marques, Fernanda, Villa de Brito, Maria J., Helena Garcia, M.

“…A new family of copper(I) complexes of general formula [Cu(dppe)(NN)]+ have been synthesized and fully characterized, with…”
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Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential by Côrte-Real, Leonor, Teixeira, Ricardo G, Gírio, Patrícia, Comsa, Elisabeta, Moreno, Alexis, Nasr, Rachad, Baubichon-Cortay, Hélène, Avecilla, Fernando, Marques, Fernanda, Robalo, M. Paula, Mendes, Paulo, Ramalho, João P. Prates, Garcia, M. Helena, Falson, Pierre, Valente, Andreia

“…New ruthenium methyl-cyclopentadienyl compounds bearing bipyridine derivatives with the general formula [Ru­(η5-MeCp)­(PPh3)­(4,4′-R-2,2′-bpy)]+ (Ru1, R = H;…”
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Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes by Côrte-Real, Leonor, Mendes, Filipa, Coimbra, Joana, Morais, Tânia S., Tomaz, Ana Isabel, Valente, Andreia, Garcia, M. Helena, Santos, Isabel, Bicho, Manuel, Marques, Fernanda

“…A set of structurally related Ru(η 5 -C 5 H 5 ) complexes with bidentate N,N′-heteroaromatic ligands have been evaluated as prospective metallodrugs, with…”
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Biotinylated polymer-ruthenium conjugates: in vitro and in vivo studies in a triple-negative breast cancer model by Côrte-Real, Leonor, Brás, Ana Rita, Pilon, Adhan, Mendes, Nuno Miguel Morais, Ribeiro, Ana Sofia, Martins, Tiago D., Farinha, José Paulo S., Oliveira, M. Conceição, Gärtner, Fátima, Garcia, M. Helena, Preto, Ana, Valente, Andreia

“…The need for new therapeutic approaches for triple-negative breast cancer is a clinically relevant problem that needs to be solved. Using a multi-targeting…”
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Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells by Teixeira, Ricardo G., Brás, Ana Rita, Côrte-Real, Leonor, Tatikonda, Rajendhraprasad, Sanches, Anabela, Robalo, M. Paula, Avecilla, Fernando, Moreira, Tiago, Garcia, M. Helena, Haukka, Matti, Preto, Ana, Valente, Andreia

“…Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1…”
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Novel "ruthenium cyclopentadienyl"-peptide conjugate complexes against human FGFR(+) breast cancer by Franco Machado, João, Machuqueiro, Miguel, Marques, Fernanda, Robalo, M Paula, Piedade, M Fátima M, Garcia, M Helena, Correia, João D G, Morais, Tânia S

“…In this work we explored the possibility of improving the selectivity of a cytotoxic Ru complex [RuCp(PPh )(2,2'-bipy)][CF SO ] (where Cp = η…”
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Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid parasites by Fernández, Mariana, Arce, Esteban Rodríguez, Sarniguet, Cynthia, Morais, Tânia S., Tomaz, Ana Isabel, Azar, Claudio Olea, Figueroa, Roberto, Diego Maya, J., Medeiros, Andrea, Comini, Marcelo, Helena Garcia, M., Otero, Lucía, Gambino, Dinorah

“…Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(η5-C5H5)(PPh3)L], with HL=bioactive 5-nitrofuryl…”
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[RuII(η5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: Cytotoxic activity and interaction with human serum albumin by Tomaz, Ana Isabel, Jakusch, Tamás, Morais, Tânia S., Marques, Fernanda, de Almeida, Rodrigo F.M., Mendes, Filipa, Enyedy, Éva A., Santos, Isabel, Pessoa, João Costa, Kiss, Tamás, Garcia, M. Helena

“…Ruthenium complexes hold great potential as alternatives to cisplatin in cancer chemotherapy. We present results on the in vitro antitumor activity of an…”
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Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes by Dömötör, Orsolya, de Almeida, Rodrigo F.M., Côrte-Real, Leonor, Matos, Cristina P., Marques, Fernanda, Matos, António, Real, Carla, Kiss, Tamás, Enyedy, Éva Anna, Helena Garcia, M., Tomaz, Ana Isabel

“…Two recently published Ru(III) complexes bearing (N2O2) tetradentate bis(aminophenolate) ligands, formulated as [Ru(III)(salan)(PPh3)Cl] (salan is the…”
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New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution by Morais, Tânia S., Santos, Filipa C., Jorge, Tiago F., Côrte-Real, Leonor, Madeira, Paulo J. Amorim, Marques, Fernanda, Robalo, M. Paula, Matos, António, Santos, Isabel, Garcia, M. Helena

“…A novel water soluble organometallic compound, [RuCp(mTPPMSNa)(2,2′-bipy)][CF3SO3] (TM85, where Cp=η5-cyclopentadienyl,…”
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The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds by Côrte-Real, Leonor, Robalo, M. Paula, Marques, Fernanda, Nogueira, Guilherme, Avecilla, Fernando, J.L. Silva, Tiago, C. Santos, Filipa, Tomaz, A. Isabel, Garcia, M. Helena, Valente, Andreia

“…A new family of eight ruthenium(II)-cyclopentadienyl bipyridine derivatives, bearing nitrogen, sulfur, phosphorous and carbonyl sigma bonded coligands, has…”
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Exploring the effect of the ligand design on the interactions between [Ru(η5-C5H5)(PPh3)(N,O)][CF3SO3] complexes and human serum albumin by Morais, Tânia S., Santos, Filipa C., Corte-Real, Leonor, Garcia, M. Helena

“…Ruthenium complexes hold a great potential in chemotherapy as an alternative to the classical platinum based drugs. The organometallic compounds studied in the…”
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Biological activity and cellular uptake of [Ru(η5-C5H5)(PPh3)(Me2bpy)][CF3SO3] complex by Morais, Tânia S., Santos, Filipa, Côrte-Real, Leonor, Marques, Fernanda, Robalo, M. Paula, Madeira, Paulo J. Amorim, Garcia, M. Helena

“…Anticancer activity of the new [Ru(η5-C5H5)(PPh3)(Me2bpy)][CF3SO3] (Me2bpy = 4,4′-dimethyl-2,2′-bipyridine) complex was evaluated in vitro against several…”
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Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands by Helena Garcia, M., Morais, Tânia S., Florindo, Pedro, Piedade, M. Fátima M., Moreno, Virtudes, Ciudad, Carlos, Noe, Veronica

“…Inhibition of the growth of LoVo human colon adenocarcinoma and MiaPaCa pancreatic cancer cell lines by two new organometallic ruthenium(II) complexes of…”
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