Search Results - "HELD, Werner"

Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation by Abbuehl, Jean-Paul, Tatarova, Zuzana, Held, Werner, Huelsken, Joerg

“…Hematopoietic stem cell (HSC) transplantation represents a curative treatment for various hematological disorders. However, delayed reconstitution of innate…”
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Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation by Danilo, Maxime, Chennupati, Vijaykumar, Silva, Joana Gomes, Siegert, Stefanie, Held, Werner

“…The formation of central CD8 T cell memory in response to infection depends on the transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive…”
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TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation by Wieland, Dominik, Kemming, Janine, Schuch, Anita, Emmerich, Florian, Knolle, Percy, Neumann-Haefelin, Christoph, Held, Werner, Zehn, Dietmar, Hofmann, Maike, Thimme, Robert

“…Differentiation and fate of virus-specific CD8 + T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1 + CD127 + PD1 +…”
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Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory by Jeannet, Grégoire, Boudousquié, Caroline, Gardiol, Noémie, Kang, Joonsoo, Huelsken, Joerg, Held, Werner, Fearon, Douglas T.

“…Immune protection from intracellular pathogens depends on the generation of terminally differentiated effector and of multipotent memory precursor CD8 T cells,…”
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Transcriptional regulation of murine natural killer cell development, differentiation and maturation by Held, Werner, Jeevan-Raj, Beena, Charmoy, Mélanie

“…Natural killer (NK) cells are innate cytotoxic effector cells that play important protective roles against certain pathogens as well as against…”
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Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity by Jaworski, Maike, Marsland, Ben J, Gehrig, Jasmine, Held, Werner, Favre, Stéphanie, Luther, Sanjiv A, Perroud, Mai, Golshayan, Déla, Gaide, Olivier, Thome, Margot

“…The protease activity of the paracaspase Malt1 has recently gained interest as a drug target for immunomodulation and the treatment of diffuse large B‐cell…”
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The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes by Jeevan-Raj, Beena, Gehrig, Jasmine, Charmoy, Mélanie, Chennupati, Vijaykumar, Grandclément, Camille, Angelino, Paolo, Delorenzi, Mauro, Held, Werner

“…The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified. Our combined…”
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Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq by Carmona, Santiago J., Siddiqui, Imran, Bilous, Mariia, Held, Werner, Gfeller, David

“…Recent studies have proposed that tumor-specific tumor-infiltrating CD8 + T lymphocytes (CD8 TIL) can be classified into two main groups: "exhausted" TILs,…”
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Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection by Welten, Suzanne P. M., Yermanos, Alexander, Baumann, Nicolas S., Wagen, Franziska, Oetiker, Nathalie, Sandu, Ioana, Pedrioli, Alessandro, Oduro, Jennifer D., Reddy, Sai T., Cicin-Sain, Luka, Held, Werner, Oxenius, Annette

“…Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of…”
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Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion by Hurrell, Benjamin P, Schuster, Steffen, Grün, Eva, Coutaz, Manuel, Williams, Roderick A, Held, Werner, Malissen, Bernard, Malissen, Marie, Yousefi, Shida, Simon, Hans-Uwe, Müller, Andreas J, Tacchini-Cottier, Fabienne

“…The protozoan Leishmania mexicana parasite causes chronic non-healing cutaneous lesions in humans and mice with poor parasite control. The mechanisms…”
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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells by Niogret, Charlène, Miah, S. M. Shahjahan, Rota, Giorgia, Fonta, Nicolas P., Wang, Haiping, Held, Werner, Birchmeier, Walter, Sexl, Veronica, Yang, Wentian, Vivier, Eric, Ho, Ping-Chih, Brossay, Laurent, Guarda, Greta

“…The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells…”
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Cis–trans interactions of cell surface receptors: biological roles and structural basis by Held, Werner, Mariuzza, Roy A.

“…Cell surface receptors bind ligands expressed on other cells (in trans ) in order to communicate with neighboring cells. However, an increasing number of cell…”
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Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways by Coudert, Jérôme D., Scarpellino, Léonardo, Gros, Frédéric, Vivier, Eric, Held, Werner

“…NKG2D is a multisubunit activation receptor that allows natural killer (NK) cells to detect and eliminate stressed, infected, and transformed host cells…”
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NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions by Ludigs, Kristina, Jandus, Camilla, Utzschneider, Daniel T., Staehli, Francesco, Bessoles, Stéphanie, Dang, Anh Thu, Rota, Giorgia, Castro, Wilson, Zehn, Dietmar, Vivier, Eric, Held, Werner, Romero, Pedro, Guarda, Greta

“…NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells. Recent evidence highlights an…”
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Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells by Scholz, Godehard, Jandus, Camilla, Zhang, Lianjun, Grandclément, Camille, Lopez-Mejia, Isabel C., Soneson, Charlotte, Delorenzi, Mauro, Fajas, Lluis, Held, Werner, Dormond, Olivier, Romero, Pedro

“…Robust, long-lasting immune responses are elicited by memory T cells that possess properties of stem cells, enabling them to persist long-term and to…”
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Caspase-3 Protects Stressed Organs against Cell Death by Khalil, Hadi, Peltzer, Nieves, Walicki, Joël, Yang, Jiang-Yan, Dubuis, Gilles, Gardiol, Noémie, Held, Werner, Bigliardi, Paul, Marsland, Benjamin, Liaudet, Lucas, Widmann, Christian

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels by Grandclément, Camille, Pick, Horst, Vogel, Horst, Held, Werner

“…Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby…”
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Investigation of a fluorescent reporter microenvironment niche labeling strategy in experimental brain metastasis by Massara, Matteo, Dolfi, Bastien, Wischnewski, Vladimir, Nolan, Emma, Held, Werner, Malanchi, Ilaria, Joyce, Johanna A.

“…Brain metastases are the most common brain tumors in patients and are associated with poor prognosis. Investigating the colonization and outgrowth of brain…”
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Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition by Alari-Pahissa, Elisenda, Grandclément, Camille, Jeevan-Raj, Beena, Leclercq, Georges, Veillette, André, Held, Werner

“…Natural Killer (NK) cells attack normal hematopoietic cells that do not express inhibitory MHC class I (MHC-I) molecules, but the ligands that activate NK…”
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The role of the NKG2D receptor for tumor immunity by Coudert, Jérôme D., Held, Werner

“…Natural killer (NK) cells have originally been identified based on their capacity to kill transformed cells in a seemingly non-specific fashion. Over the last…”
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