Search Results - "HELD, Matthew"

Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient Care by Kodack, David P., Farago, Anna F., Dastur, Anahita, Held, Matthew A., Dardaei, Leila, Friboulet, Luc, von Flotow, Friedrich, Damon, Leah J., Lee, Dana, Parks, Melissa, Dicecca, Richard, Greenberg, Max, Kattermann, Krystina E., Riley, Amanda K., Fintelmann, Florian J., Rizzo, Coleen, Piotrowska, Zofia, Shaw, Alice T., Gainor, Justin F., Sequist, Lecia V., Niederst, Matthew J., Engelman, Jeffrey A., Benes, Cyril H.

“…Personalized cancer therapy is based on a patient’s tumor lineage, histopathology, expression analyses, and/or tumor DNA or RNA analysis. Here, we aim to…”
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Genotype-selective combination therapies for melanoma identified by high-throughput drug screening by Held, Matthew A, Langdon, Casey G, Platt, James T, Graham-Steed, Tisheeka, Liu, Zongzhi, Chakraborty, Ashok, Bacchiocchi, Antonella, Koo, Andrew, Haskins, Jonathan W, Bosenberg, Marcus W, Stern, David F

“…Resistance and partial responses to targeted monotherapy are major obstacles in cancer treatment. Systematic approaches to identify efficacious drug…”
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Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis by Held, Matthew A., Greenfest-Allen, Emily, Jachimowicz, Edward, Stoeckert, Christian J., Stokes, Matthew P., Wood, Antony W., Wojchowski, Don M.

“…•Phospho-PTM proteomics reveals diverse new EPO-modulated signaling targets.•Novel EPO-modulated adaptor proteins DLG-1, DLG-3, WAS-L, and WAS-P network as…”
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Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer by Wali, Vikram B, Langdon, Casey G, Held, Matthew A, Platt, James T, Patwardhan, Gauri A, Safonov, Anton, Aktas, Bilge, Pusztai, Lajos, Stern, David F, Hatzis, Christos

“…Triple-negative breast cancer (TNBC) remains an aggressive disease without effective targeted therapies. In this study, we addressed this challenge by testing…”
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Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling by Held, Matthew A., Greenfest-Allen, Emily, Su, Su, Stoeckert, Christian J., Stokes, Matthew P., Wojchowski, Don M.

“…The formation of erythroid progenitor cells depends sharply upon erythropoietin (EPO), its cell surface receptor (erythropoietin receptor, EPOR), and Janus…”
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Characterization of Melanoma Cells Capable of Propagating Tumors from a Single Cell by HELD, Matthew A, CURLEY, David P, DANKORT, David, MCMAHON, Martin, MUTHUSAMY, Viswanathan, BOSENBERG, Marcus W

“…Questions persist about the nature and number of cells with tumor-propagating capability in different types of cancer, including melanoma. In part, this is…”
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The effects of bruising and temperature on enzyme activity and textural qualities of tomato juice by Held, Matthew T, Anthon, Gordon E, Barrett, Diane M

“…BACKGROUND During harvest and transportation, processing tomatoes are exposed to elevated temperatures, compression and vibration in the harvester and truck,…”
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Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer by Colavito, Sierra A, Platt, James T, Held, Matthew A, Liu, Zongzhi, Sokup, Ryan, Stern, David F

“…Mesenchymal stem-like (MSL) breast cancers are enriched for cells with tumor reconstituting and mesenchymal characteristics. These cancers are often…”
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BRAF Inhibition Decreases Cellular Glucose Uptake in Melanoma in Association with Reduction in Cell Volume by Theodosakis, Nicholas, Held, Matthew A, Marzuka-Alcala, Alexander, Meeth, Katrina M, Micevic, Goran, Long, Georgina V, Scolyer, Richard A, Stern, David F, Bosenberg, Marcus W

“…BRAF kinase inhibitors have dramatically affected treatment of BRAF(V600E) (/) (K)-driven metastatic melanoma. Early responses assessed using…”
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Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor by Langdon, Casey G, Platt, James T, Means, Robert E, Iyidogan, Pinar, Mamillapalli, Ramanaiah, Klein, Michael, Held, Matthew A, Lee, Jong Woo, Koo, Ja Seok, Hatzis, Christos, Hochster, Howard S, Stern, David F

“…Pancreatic adenocarcinoma (PDAC) is the fourth most common cause of cancer-related death in the United States. PDAC is difficult to manage effectively, with a…”
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DCDC2 Is Associated with Reading Disability and Modulates Neuronal Development in the Brain by Haiying Meng, Smith, Shelley D., Karl Hager, Held, Matthew, Jonathan Liu, Olson, Richard K., Pennington, Bruce F., DeFries, John C., Gelernter, Joel, Thomas O'Reilly-Pol, Somlo, Stefan, Skudlarski, Pawel, Shaywitz, Sally E., Shaywitz, Bennett A., Karen Marchione, Wang, Yu, Murugan Paramasivam, LoTurco, Joseph J., Page, Grier P., Jeffrey R. Gruen

“…DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide…”
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Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers by Kremer, Jeff Charles, Prudner, Bethany Cheree, Lange, Sara Elaine Stubbs, Bean, Gregory Richard, Schultze, Matthew Bailey, Brashears, Caitlyn Brook, Radyk, Megan DeAnna, Redlich, Nathan, Tzeng, Shin-Cheng, Kami, Kenjiro, Shelton, Laura, Li, Aixiao, Morgan, Zack, Bomalaski, John Stephen, Tsukamoto, Takashi, McConathy, Jon, Michel, Loren Scott, Held, Jason Matthew, Van Tine, Brian Andrew

“…Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate…”
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SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells by Langdon, Casey G, Wiedemann, Norbert, Held, Matthew A, Mamillapalli, Ramanaiah, Iyidogan, Pinar, Theodosakis, Nicholas, Platt, James T, Levy, Frederic, Vuagniaux, Gregoire, Wang, Shaomeng, Bosenberg, Marcus W, Stern, David F

“…Targeting anti-apoptotic proteins can sensitize tumor cells to conventional chemotherapies or other targeted agents. Antagonizing the Inhibitor of Apoptosis…”
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The broad-spectrum receptor tyrosine kinase inhibitor dovitinib suppresses growth of BRAF-mutant melanoma cells in combination with other signaling pathway inhibitors by Langdon, Casey G., Held, Matthew A., Platt, James T., Meeth, Katrina, Iyidogan, Pinar, Mamillapalli, Ramanaiah, Koo, Andrew B., Klein, Michael, Liu, Zongzhi, Bosenberg, Marcus W., Stern, David F.

“…Summary BRAF inhibitors have revolutionized treatment of mutant BRAF metastatic melanomas. However, resistance develops rapidly following BRAF inhibitor…”
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Tumor Necrosis Factor α-dependent Up-regulation of Lrh-1 and Mrp3(Abcc3) Reduces Liver Injury in Obstructive Cholestasis by Bohan, Alan, Chen, Wen-Sheng, Denson, Lee A., Held, Matthew A., Boyer, James L.

“…Mrp3(Abcc3) is markedly induced following bile duct ligation (BDL) in the rat and in some human cholestatic liver diseases and is believed to ameliorate liver…”
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Isolation of total RNA from transgenic mouse melanoma subsets using fluorescence-activated cell sorting by Tighe, Scott, Held, Matthew A

“…The majority of tumors, including melanoma, are phenotypically heterogeneous in that they contain various cell populations with differential expression of cell…”
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Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3 by Denson, Lee A, Held, Matthew A, Menon, Ram K, Frank, Stuart J, Parlow, Albert F, Arnold, Dodie L

“…Cytokines may cause an acquired growth hormone (GH) resistance in patients with inflammatory diseases. Anabolic effects of GH are mediated through activation…”
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Tumor Necrosis Factor α Blockade Restores Growth Hormone Signaling in Murine Colitis by Difedele, Lisa M., He, Jiman, Bonkowski, Erin L., Han, Xiaonan, Held, Matthew A., Bohan, Alan, Menon, Ram K., Denson, Lee A.

“…Background & Aims: Cytokines including tumor necrosis factor α (TNFα) may create a state of growth hormone (GH) resistance in Crohn’s disease. Anabolic effects…”
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Organ-specific alterations in RARα:RXRα abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis by Denson, Lee A., Bohan, Alan, Held, Matthew A., Boyer, James L.

“…Background & Aims: Obstructive cholestasis is associated with adaptive changes in expression of hepatocyte transport proteins. These include a significant…”
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Genetic alterations in malignant melanoma by Held, Matthew A, Bosenberg, Marcus W

“…Abstract Many advances in the understanding of the genetic and cellular events that drive melanoma formation have occurred in the last decade. Despite…”
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