Search Results - "HELD, Daniel M"

HIV-1 inactivation by nucleic acid aptamers by Held, Daniel M, Kissel, Jay D, Patterson, James T, Nickens, David G, Burke, Donald H

“…Although developments in small-molecule therapeutics for HIV-1 have been dramatic in recent years, the rapid selection of drug-resistant viral strains and the…”
Get full text

Differential Susceptibility of HIV-1 Reverse Transcriptase to Inhibition by RNA Aptamers in Enzymatic Reactions Monitoring Specific Steps during Genome Replication by Held, Daniel M., Kissel, Jay D., Saran, Dayal, Michalowski, Daniel, Burke, Donald H.

“…Nucleic acid aptamers to HIV-1 reverse transcriptase (RT) are potent inhibitors of DNA polymerase function in vitro, and they have been shown to inhibit viral…”
Get full text

Vaccination of Rabbits with an Alkylated Toxoid Rapidly Elicits Potent Neutralizing Antibodies against Botulinum Neurotoxin Serotype B by Held, Daniel M, Shurtleff, Amy C, Fields, Scott, Green, Christopher, Fong, Julie, Jones, Russell G A, Sesardic, Dorothea, Buelow, Roland, Burke, Rae Lyn

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Cross-Clade Inhibition of Recombinant Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus SIVcpz Reverse Transcriptases by RNA Pseudoknot Aptamers by HELD, Daniel M, KISSEL, Jay D, THACKER, Sarah J, MICHALOWSKI, Daniel, SARAN, Dayal, JIANFEI JI, HARDY, Richard W, ROSSI, John J, BURKE, Donald H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases by Michalowski, Daniel, Chitima-Matsiga, Rebecca, Held, Daniel M, Burke, Donald H

“…DNA aptamers RT5, RT6 and RT47 form a group of related sequences that inhibit HIV-1 reverse transcriptase (RT). The essential inhibitory structure is…”
Get full text

Evolutionary landscapes for the acquisition of new ligand recognition by RNA aptamers by Held, Daniel M, Greathouse, S Travis, Agrawal, Amit, Burke, Donald H

“…The evolution of ligand specificity underlies many important problems in biology, from the appearance of drug resistant pathogens to the re-engineering of…”
Get full text

Multiple-turnover thio-ATP hydrolase and phospho-enzyme intermediate formation activities catalyzed by an RNA enzyme by Saran, Dayal, Held, Daniel M., Burke, Donald H.

“…Ribozymes that phosphorylate internal 2′-OH positions mimic the first mechanistic step of P-type ATPase enzymes by forming a phospho-enzyme intermediate. We…”
Get full text

Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers by Kissel, Jay D, Held, Daniel M, Hardy, Richard W, Burke, Donald H

“…Nucleic acid aptamers can potentially be developed as broad-spectrum antiviral agents. Single-stranded DNA (ssDNA) aptamer RT1t49 inhibits reverse…”
Get full text

Single-stranded DNA aptamer RT1t49 inhibits RT polymerase and RNase H functions of HIV type 1, HIV type 2, and SIVCPZ RTs by Kissel, Jay D, Held, Daniel M, Hardy, Richard W, Burke, Donald H

“…Natural and selected resistance of HIV-1 to current anti-HIV drugs continues to pose serious problems to the development of HIV-1 antivirals. The viral reverse…”
Get more information

Review: Pomson, Alex and Randy S. Schnoor, Jewish Family: Identity and Self- Formation at Home by Daniel M. Held

Get full text

RNA aptamer inhibitors of HIV reverse transcriptase: Molecular evolution and determinants of target specificity by Held, Daniel M

“…The nature of intermolecular interactions between proteins and nucleic acids is governed by evolutionary constraints imposed on those biological…”
Get full text

RNA aptamer inhibitors of HIV reverse transcriptase: Molecular evolution and determinants of target specificity by Held, Daniel M

“…The nature of intermolecular interactions between proteins and nucleic acids is governed by evolutionary constraints imposed on those biological…”
Get full text