Catheter-associated fungemia due to Exophiala oligosperma in a leukemic child and review of fungemia cases caused by Exophiala species

A case of catheter-associated fungemia due to Exophiala oligosperma in a 3-year-old leukemic child is presented. The etiologic agent was isolated from blood specimens and the catheter tip. The isolate was identified by its morphological characteristics and DNA sequencing of the internal transcribed...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of clinical microbiology & infectious diseases Vol. 25; no. 11; pp. 729 - 732
Main Authors:	AL-OBAID, I, AHMAD, S, KHAN, Z. U, DINESH, B, HEJAB, H. M
Format:	Journal Article
Language:	English
Published:	Berlin Springer 01-11-2006 Springer Nature B.V
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Catheterization, Central Venous - adverse effects Catheters Child, Preschool Exophiala - classification Exophiala - genetics Exophiala - isolation & purification Female Fungemia - microbiology Hematologic and hematopoietic diseases Human mycoses Humans Infectious diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical instruments Medical sciences Mycoses Mycoses - microbiology Mycotic sepsis Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Human Mycosis Microbiology Leukemia Catheter Malignant hemopathy Fever Fungi Infection Antiprotozoal agent Antibiotic Antifungal agent Fungemia Treatment Amphotericin B Polyenic compound Triazole derivatives Parasiticide Fungi Imperfecti Child Exophiala Bibliographic review Thallophyta Itraconazole
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A case of catheter-associated fungemia due to Exophiala oligosperma in a 3-year-old leukemic child is presented. The etiologic agent was isolated from blood specimens and the catheter tip. The isolate was identified by its morphological characteristics and DNA sequencing of the internal transcribed spacer region of rDNA. Despite initial amphotericin B and itraconazole therapy, the child's fever subsided only after removal of the catheter. A review of the medical literature revealed 29 cases of infection due to Exophiala species. Twenty-three of these 29 patients had a CVC in place when they developed fever or other manifestations of fungemia. Withdrawal of the CVC together with amphotericin B and/or itraconazole therapy generally resulted in a good prognosis.
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	0934-9723 1435-4373
DOI:	10.1007/s10096-006-0205-0