Risk Markers of Oral Cancer in Clinically Normal Mucosa As an Aid in Smoking Cessation Counseling

Risk Markers of Oral Cancer in Clinically Normal Mucosa As an Aid in Smoking Cessation Counseling

Quitting smoking may prevent oral cancer. Behavioral intervention to quit smoking may be more efficient if persons are assigned an individual risk of cancer. In this prospective study, we provided counseling and behavioral intervention toward smoking cessation, supplemented by genetic analyses in cl...

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Bibliographic Details
Published in:Journal of clinical oncology Vol. 23; no. 9; pp. 1927 - 1933
Main Authors: SUDBØ, Jon, SAMUELSSON, Roy, BERNER, Asmund, RISBERG, Björn, HEISTEIN, Stig, NYHUS, Christian, SAMUELSSON, Margaretha, PUNTERVOLD, Ruth, SIGSTAD, Eva, DAVIDSON, Ben, REITH, Albrecht
Format: Journal Article
Language:English
Published: Baltimore, MD American Society of Clinical Oncology 20-03-2005
Lippincott Williams & Wilkins
Subjects:
Adult
Behavior Therapy - methods
Biological and medical sciences
Biomarkers, Tumor
Counseling
Cytogenetic Analysis
Female
Humans
Leukoplakia, Oral - etiology
Leukoplakia, Oral - pathology
Male
Medical sciences
Middle Aged
Mouth Mucosa - pathology
Mouth Neoplasms - etiology
Mouth Neoplasms - genetics
Mouth Neoplasms - prevention & control
Ploidies
Prospective Studies
Smoking - adverse effects
Smoking Cessation
Smoking Prevention
Tobacco, tobacco smoking
Toxicology
Tumors
Oral cavity
Cancerology
Genetic counseling
Oral cancer
Stomatology
Mucosa
Risk factor
Tobacco smoking
Biological marker
Oral cavity disease
Malignant tumor
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Summary:Quitting smoking may prevent oral cancer. Behavioral intervention to quit smoking may be more efficient if persons are assigned an individual risk of cancer. In this prospective study, we provided counseling and behavioral intervention toward smoking cessation, supplemented by genetic analyses in clinically normal oral mucosa of heavy smokers. Measurement of serum cotinine was used to assess changes in smoking habits. In cytologic scrapings from 275 heavy smokers with clinically normal mucosa, we found tetraploidy in four and aneuploidy in 19 persons (23 of 275; 8%). Twenty one (91%) of 23 persons with aneuploidy had quit or reduced their smoking habits at the 3-month follow-up, 20 (87%) of 23 persons had done so at 12 months, and 21 (91%) of 23 persons had done so at 24 months. Fifty-one (20%) of the 252 persons without genetic changes in their mucosa had quit or reduced their tobacco habits at the 3-month follow-up, 23 (9%) had done so at 12 months, and 17 (7%) had done so at 24 months (P < .001). After 24 months, normalization of DNA content to diploidy was observed in two of four persons with tetraploid (50%), and in 11 of 19 persons (58%) with aneuploid scrapings. One patient developed an oral carcinoma in the floor of the mouth: this patient had an aneuploid scraping obtained 43 months earlier and developed a leukoplakia 28 months before the carcinoma. Risk markers of oral cancer are present in clinically normal mucosa of heavy smokers, and such findings enhance the adherence to smoking cessation on counseling. Cytogenetic aberrations may normalize after quitting smoking.
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ISSN:0732-183X
1527-7755
DOI:10.1200/JCO.2005.03.172