Search Results - "HEINECKE, J. W"

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima by Hazen, S L, Heinecke, J W

“…Oxidation of LDL may be of pivotal importance in atherogenesis, but the mechanisms that promote oxidation in vivo remain poorly understood. We have explored…”
Get full text

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis by Heinecke, Jay W

“…The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified to trigger the pathological events of atheroscleosis. In this…”
Get full text

8-Nitro-2‘-deoxyguanosine, a Specific Marker of Oxidation by Reactive Nitrogen Species, Is Generated by the Myeloperoxidase−Hydrogen Peroxide−Nitrite System of Activated Human Phagocytes by Byun, J, Henderson, J. P, Mueller, D. M, Heinecke, J. W

“…Reactive intermediates generated by phagocytes damage DNA and may contribute to the link between chronic inflammation and cancer. Myeloperoxidase, a heme…”
Get full text

Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease by GOKCE, N, KEANEY, J. F, FREI, B, HOLBROOK, M, OLESIAK, M, ZACHARIAH, B. J, LEEUWENBURGH, C, HEINECKE, J. W, VITA, J. A

“…Loss of endothelium-derived nitric oxide (EDNO) contributes to the clinical expression of coronary artery disease (CAD). Increased oxidative stress has been…”
Get full text

Increased atherosclerosis in myeloperoxidase-deficient mice by Brennan, M L, Anderson, M M, Shih, D M, Qu, X D, Wang, X, Mehta, A C, Lim, L L, Shi, W, Hazen, S L, Jacob, J S, Crowley, J R, Heinecke, J W, Lusis, A J

“…Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local…”
Get full text

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein by SAVENKOVA, M. I, MUELLER, D. M, HEINECKE, J. W

“…Myeloperoxidase, a heme protein secreted by activated phagocytes, is expressed in human atherosclerotic lesions. The enzyme uses H2O2 generated by the cells to…”
Get full text

Oxidative stress and antioxidants in exercise by Leeuwenburgh, C, Heinecke, J W

“…Increased aerobic metabolism during exercise is a potential source of oxidative stress. In muscle, mitochondria are one important source of reactive…”
Get more information

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions by Daugherty, A, Dunn, J L, Rateri, D L, Heinecke, J W

“…Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified…”
Get full text

The mystery of diabetes and atherosclerosis: time for a new plot by Semenkovich, C. F., Heinecke, J. W.

“…The mystery of diabetes and atherosclerosis: time for a new plot. C F Semenkovich and J W Heinecke Department of Medicine, Washington University School of…”
Get full text

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages by J W Heinecke, W Li, H L Daehnke, 3rd, J A Goldstein

“…Myeloperoxidase, secreted by activated phagocytes, produces the powerful cytotoxin hypochlorous acid from H2O2 and Cl-. We show that the enzyme can also employ…”
Get full text

Is the Emperor Wearing Clothes?: Clinical Trials of Vitamin E and the LDL Oxidation Hypothesis by Heinecke, Jay W

“…A wealth of evidence indicates that oxidized low density lipoprotein (LDL) may be of central importance in animal models of atherogenesis. In recent clinical…”
Get full text

Human neutrophils employ chlorine gas as an oxidant during phagocytosis by Hazen, S L, Hsu, F F, Mueller, D M, Crowley, J R, Heinecke, J W

“…Reactive oxidants generated by phagocytes are of central importance in host defenses, tumor surveillance, and inflammation. One important pathway involves the…”
Get full text

Iron overload diminishes atherosclerosis in apoE-deficient mice by Kirk, E A, Heinecke, J W, LeBoeuf, R C

“…It has been proposed that elevated levels of tissue iron increase the risk for atherosclerosis, perhaps by favoring the formation of pro-atherogenic oxidized…”
Get full text

Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway by Kawamura, M, Heinecke, J W, Chait, A

“…Oxidized lipoproteins may be important in the pathogenesis of atherosclerosis. Because diabetic subjects are particularly prone to vascular disease, and…”
Get full text

Oxidation of low density lipoprotein by thiols : superoxide-dependent and -independent mechanisms by HEINECKE, J. W, KAWAMURA, M, SUZUKI, L, CHAIT, A

“…Oxidatively damaged low density lipoprotein (LDL) may cause macrophages to accumulate cholesterol in an unregulated manner, initiating the development of…”
Get full text

Copper Ions Promote Peroxidation of Low Density Lipoprotein Lipid by Binding to Histidine Residues of Apolipoprotein B100, But They Are Reduced at Other Sites on LDL by Wagner, Peter, Heinecke, Jay W

“…Oxidized LDL is implicated in the pathogenesis of atherosclerosis. A widely studied model for oxidation of the lipid in LDL involves Cu. Recent studies suggest…”
Get full text

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells by HEINECKE, J. W, BAKER, L, ROSEN, H, CHAIT, A

“…Extracellular superoxide was detected in cultures of monkey and human arterial smooth muscle cells as indicated by superoxide dismutase inhibitable reduction…”
Get full text

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture by HEINECKE, J. W, ROSEN, H, CHAIT, A

“…Modification of low density lipoproteins by human arterial smooth muscle cells was characterized by increased electrophoretic mobility and increased content of…”
Get full text

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells by Heinecke, J.W., Rosen, H., Suzuki, L.A., Chait, A.

“…Extracellular superoxide (O2-.) was detected in cultures of monkey arterial smooth muscle cells as measured by the superoxide dismutase-inhibitable reduction…”
Get full text

The Eosinophil Peroxidase-Hydrogen Peroxide-Bromide System of Human Eosinophils Generates 5-Bromouracil, a Mutagenic Thymine Analogue by Henderson, Jeffrey P, Byun, Jaeman, Mueller, Dianne M, Heinecke, Jay W

“…Eosinophils use eosinophil peroxidase, hydrogen peroxide (H2O2), and bromide ion (Br-) to generate hypobromous acid (HOBr), a brominating intermediate. This…”
Get full text