Search Results - "HEINE, R. J"

Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis by KNOL, M. J, TWISK, J. W. R, BEEKMAN, A. T. F, HEINE, R. J, SNOEK, F. J, POUWER, F

“…Evidence strongly suggests that depression and type 2 diabetes are associated, but the direction of the association is still unclear. Depression may occur as a…”
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Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE Investigation by van Halm, V P, Peters, M J L, Voskuyl, A E, Boers, M, Lems, W F, Visser, M, Stehouwer, C D A, Spijkerman, A M W, Dekker, J M, Nijpels, G, Heine, R J, Bouter, L M, Smulders, Y M, Dijkmans, B A C, Nurmohamed, M T

“…Patients with rheumatoid arthritis (RA) have an increased cardiovascular risk, but the magnitude of this risk is not known precisely. A study was undertaken to…”
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Applying a cost-based pricing model for innovative cancer treatments subject to indication expansion: A case study for pembrolizumab and daratumumab by Heine, R J S D, Thielen, F W, Mathijssen, R H J, van Leeuwen, R W F, Franken, M G, Uyl-de Groot, C A

“…Expanding the indication of already approved immuno-oncology drugs presents treatment opportunities for patients but also strains healthcare systems…”
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Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy : A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes by NATHAN, D. M, BUSE, J. B, DAVIDSON, M. B, HEINE, R. J, HOLMAN, R. R, SHERWIN, R, ZINMAN, B

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Diabetes, prediabetes and cancer mortality by Zhou, X. H, Qiao, Q, Zethelius, B, Pyörälä, K, Söderberg, S, Pajak, A, Stehouwer, C. D. A, Heine, R. J, Jousilahti, P, Ruotolo, G, Nilsson, P. M, Calori, G, Tuomilehto, J

“…Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods…”
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Diabetes-specific emotional distress mediates the association between depressive symptoms and glycaemic control in Type 1 and Type 2 diabetes by Van Bastelaar, K. M. P., Pouwer, F., Geelhoed-Duijvestijn, P. H. L. M., Tack, C. J., Bazelmans, E., Beekman, A. T., Heine, R. J., Snoek, F. J.

“…Diabet. Med. 27, 798–803 (2010) Objectives  To investigate whether diabetes‐specific emotional distress mediates the relationship between depression and…”
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Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats by OUWENS, D. M, BOER, C, FODOR, M, DE GALAN, P, HEINE, R. J, MAASSEN, J. A, DIAMANT, M

“…Diabetic cardiomyopathy (DCM) is common in type 2 diabetes. In DCM, insulin resistance may alter cardiac substrate supply and utilisation leading to changes in…”
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Diabetic encephalopathy: A concept in need of a definition by Mijnhout, G S, Scheltens, P, Diamant, M, Biessels, G J, Wessels, A M, Simsek, S, Snoek, F J, Heine, R J

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Prevalence of comorbid depression is high in out-patients with Type 1 or Type 2 diabetes mellitus. Results from three out-patient clinics in the Netherlands by Pouwer, F., Geelhoed-Duijvestijn, P. H. L. M., Tack, C. J., Bazelmans, E., Beekman, A.-J., Heine, R. J., Snoek, F. J.

“…Diabet. Med. 27, 217–224 (2010) Aims  Depression is common in diabetes, but the scope of the problem and associated correlates are not well established in…”
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Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial by Foley, J. E., Bunck, M. C., Möller-Goede, D. L., Poelma, M., Nijpels, G., Eekhoff, E. M., Schweizer, A., Heine, R. J., Diamant, M.

“…Aims/hypothesis Traditional blood glucose lowering agents do not prevent the progressive loss of beta cell function in patients with type 2 diabetes. The…”
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Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps by Groenewoud, M. J, Dekker, J. M, Fritsche, A, Reiling, E, Nijpels, G, Heine, R. J, Maassen, J. A, Machicao, F, Schäfer, S. A, Häring, H. U, t Hart, L. M, van Haeften, T. W

“…Aims/hypothesis Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects of six of…”
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HbA₁c and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study by Borg, R, Kuenen, J. C, Carstensen, B, Zheng, H, Nathan, D. M, Heine, R. J, Nerup, J, Borch-Johnsen, K, Witte, D. R

“…Aims Increased glucose excursions and postprandial hyperglycaemia have been suggested as unique risk factors for cardiovascular disease (CVD) and mortality in…”
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Inflammation and endothelial dysfunction are associated with retinopathy : the Hoorn Study by VAN HECKE, M. V, DEKKER, J. M, NIJPELS, G, MOLL, A. C, HEINE, R. J, BOUTER, L. M, POLAK, B. C. P, STEHOUWER, C. D. A

“…The exact pathogenesis of retinopathy in diabetic and non-diabetic individuals is incompletely understood, but may involve chronic low-grade inflammation and…”
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The islet autoantibody titres: their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus by Van Deutekom, A. W., Heine, R. J., Simsek, S.

“…Latent autoimmune diabetes in the adult (LADA) is a slowly progressive form of autoimmune diabetes, characterized by diabetes‐associated autoantibody…”
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Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study by VAN DAMP, R. M, DEKKER, J. M, NIJPELS, G, STEHOUWER, C. D. A, BOUTER, L. M, HEINE, R. J

“…Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee…”
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Hyperglycaemia is associated with all-cause and cardiovascular mortality in the hoorn population : the Hoorn Study by DE VEGT, F, DEKKER, J. M, RUHE, H. G, STEHOUWER, C. D. A, NIJPELS, G, BOUTER, L. M, HEINE, R. J

“…The degree of glycaemia has been shown to be associated with all-cause and cardiovascular mortality in diabetic subjects. Whether this association also exists…”
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Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease by HEINE, R. J, DEKKER, J. M

“…Type II (non-insulin-dependent) diabetes mellitus is associated with a considerably enhanced risk of cardiovascular disease morbidity and mortality. Several…”
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Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy by Wessels, A. M, Simsek, S, Remijnse, P. L, Veltman, D. J, Biessels, G. J, Barkhof, F, Scheltens, P, Snoek, F. J, Heine, R. J, Rombouts, S. A. R. B

“…Aims/hypothesis In addition to nephropathy, retinopathy and peripheral neuropathy, a microvascular complication of type 1 diabetes that may be tentatively…”
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Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA₁c: the A1C-Derived Average Glucose (ADAG) study by Borg, R, Kuenen, J. C, Carstensen, B, Zheng, H, Nathan, D. M, Heine, R. J, Nerup, J, Borch-Johnsen, K, Witte, D. R

“…Aims/hypothesis Real-life glycaemic profiles of healthy individuals are poorly studied. Our aim was to analyse to what extent individuals without diabetes…”
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Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus by Maassen, J. A, Romijn, J. A, Heine, R. J

“…Type 2 diabetes is associated with excessive food intake and a sedentary lifestyle. Local inflammation of white adipose tissue induces cytokine-mediated…”
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