Search Results - "HEIMBROOK, D. C"

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F by IVEY-HOYLE, M, CONROY, R, HUBER, H. E, GOODHART, P. J, OLIFF, A, HEIMBROOK, D. C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identification of a novel retinoblastoma gene product binding site on human papillomavirus type 16 E7 protein by PATRICK, D. R, OLIFF, A, HEIMBROOK, D. C

“…Transformation of mammalian cells by human papillomavirus type 16 appears to require binding of the viral E7 protein to the cellular retinoblastoma growth…”
Get full text

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein by HUANG, P. S, PATRICK, D. R, EDWARDS, G, GOODHARDT, P. J, HUBER, H. E, MILES, L, GARSKY, V. M, OLIFF, A, HEIMBROOK, D. C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Transcription Factor E2F Binds DNA as a Heterodimer by Huber, Hans E., Edwards, Gwynneth, Goodhart, Paula J., Patrick, Denis R., Huang, Pearl S., Ivey-Hoyle, Mona, Barnett, Stanley F., Oliff, Allen, Heimbrook, David C.

“…E2F is a mammalian transcription factor that appears to play an important role in cell cycle control. DNA affinity column-purified E2F from HeLa cells…”
Get full text

Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models by LOBELL, Robert B, OMER, Charles A, KRAL, Astrid M, DONGMING LIU, LUMMA, William C, MACHOTKA, Samuel V, RANDS, Elaine, WILLIAMS, Theresa M, GRAHAM, Samuel L, HARTMAN, George D, OLIFF, Allen I, HEIMBROOK, David C, ABRAMS, Marc T, KOHL, Nancy E, BHIMNATHWALA, Hema G, BRUCKER, Mary Jo, BUSER, Carolyn A, DAVIDE, Joseph P, DESOLMS, S. Jane, DINSMORE, Christopher J, ELLIS-HUTCHINGS, Michelle S

“…Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the ras oncogene and are currently…”
Get full text

Phase I clinical study of the recombinant oncotoxin TP40 in superficial bladder cancer by GOLDBERG, M. R, HEIMBROOK, D. C, CRAWFORD, E. D, OLIFF, A. I, PASTAN, I. H, RUSSO, P, SAROSDY, M. F, GREENBERG, R. E, GIANTONIO, B. J, LINEHAN, W. M, WALTHER, M, FISHER, H. A. G, MESSING, E

“…Transforming growth factor alpha-Pseudomonas exotoxin-40 (TP40) is a hybrid fusion protein that selectively binds to cancer cells that express the epidermal…”
Get full text

Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein by JONES, R. E, WEGRZYN, R. J, PATRICK, D. R, BALISHIN, N. L, VUOCOLO, G. A, RIEMEN, M. W, DEFEO-JONES, D, GARSKY, V. M, HEIMBROOK, D. C, OLIFF, A

“…Complex formation between the human papilloma virus type-16 E7 protein (HPV-16 E7) and the retinoblastoma suppressor protein (pRB) is believed to be important…”
Get full text

Transforming Growth Factor α-Pseudomonas Exotoxin Fusion Protein Prolongs Survival of Nude Mice Bearing Tumor Xenografts by Heimbrook, David C., Stirdivant, Steven M., Ahern, Janet D., Balishin, Nancy L., Patrick, Denis R., Edwards, Gwynneth M., Defeo-Jones, Deborah, FitzGerald, David J., Pastan, Ira, Oliff, Allen

“…Transforming growth factor α (TGFα)-Pseudomonas exotoxin 40 (PE40) is a chimeric protein consisting of an N-terminal TGFα domain fused to a C-terminal 40-kDa…”
Get full text

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product by STIRDIVANT, S. M, HUBER, H. E, PATRICK, D. R, DEFEO-JONES, D, MCAVOY, E. M, GARSKY, V. M, OLIFF, A, HEIMBROOK, D. C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Carboxyl-terminal Modification of a Gastrin Releasing Peptide Derivative Generates Potent Antagonists by Heimbrook, D C, Saari, W S, Balishin, N L, Friedman, A, Moore, K S, Reimen, M W, Kiefer, D M, Rotberg, N S, Wallen, J W, Oliff, A

“…Gastrin releasing peptide (GRP) is a 27-residue peptide hormone which is analogous to the amphibian peptide bombesin. GRP serves a variety of physiological…”
Get full text

Minimal ligand analysis of gastrin releasing peptide. Receptor binding and mitogenesis by Heimbrook, D C, Boyer, M E, Garsky, V M, Balishin, N L, Kiefer, D M, Oliff, A, Riemen, M W

“…Gastrin releasing peptide (GRP) is a peptide hormone containing 27 amino acids which is structurally analogous to the amphibian peptide bombesin. GRP serves a…”
Get full text

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins by EDWARDS, G. M, DEFEO-JONES, D, TAI, J. Y, VUOCOLO, G. A, PATRICK, D. R, HEIMBROOK, D. C, OLIFF, A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Copper-dependent cleavage of DNA by bleomycin by Ehrenfeld, Guy M, Shipley, Joshua B, Heimbrook, David C, Sugiyama, Hiroshi, Long, Eric C, Van Boom, Jacques H, Van der Marel, Gijs A, Oppenheimer, Norman J, Hecht, Sidney M

“…DNA strand scission by bleomycin in the presence of Cu and Fe was further characterized. It was found that DNA degradation occurred readily upon admixture of…”
Get full text

High-density functional gastrin releasing peptide receptors on primate cells by Heimbrook, D C, Wallen, J W, Balishin, N L, Friedman, A, Oliff, A

“…Gastrin releasing peptide (GRP) is a 27 amino acid hormone that elicits a variety of biological effects. Receptor-binding antagonists of GRP may have…”
Get more information

Specific N-methylations of HPV-16 E7 peptides alter binding to the retinoblastoma suppressor protein by Jones, R E, Heimbrook, D C, Huber, H E, Wegrzyn, R J, Rotberg, N S, Stauffer, K J, Lumma, P K, Garsky, V M, Oliff, A

“…Complex formation between the human papilloma virus type 16 E7 protein (HPV-16 E7) and the retinoblastoma growth suppressor protein (RB) is believed to…”
Get full text

Biochemistry of misonidazole reduction by NADPH-cytochrome c (P-450) reductase by Heimbrook, D C, Sartorelli, A C

“…The biochemical mechanism for the reduction of misonidazole [1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol] by purified rabbit liver NADPH-cytochrome c (P-450)…”
Get more information

Purification and characterization of a functionally homogeneous 60-kDa species of the retinoblastoma gene product by EDWARDS, G. M, HUBER, H. E, HEIMBROOK, D. C, DEFEO-JONES, D, VUOCOLO, G, GOODHART, P. J, MAIGETTER, R. Z, SANYALL, G, SANYAL, G, OLIFF, A

“…The retinoblastoma susceptibility gene (RB) encodes a 928-amino acid protein (pRB) that is hypothesized to function in a pathway that restricts cell…”
Get full text

Therapeutic intervention and signaling by Heimbrook, David C, Oliff, Allen

“…Significant advances in our understanding of intracellular signal transduction pathways have emerged within the past several years. It is now apparent that,…”
Get full text

Retinoblastoma protein binding properties are dependent on 4 cysteine residues in the protein binding pocket by Stirdivant, S M, Ahern, J D, Oliff, A, Heimbrook, D C

“…The retinoblastoma gene product (pRB) participates in regulating mammalian cell replication. The mechanism responsible for pRB's growth regulatory activity is…”
Get full text

Characterization of functional HPV-16 E7 protein produced in Escherichia coli by Patrick, D R, Zhang, K, Defeo-Jones, D, Vuocolo, G R, Maigetter, R Z, Sardana, M K, Oliff, A, Heimbrook, D C

“…Human papillomaviruses (HPVs) are the etiologic agents responsible for genital warts and are contributing factors in the pathogenesis of human cervical cancer…”
Get full text